Neuropsychological Correlates of Major Depression: A Short-term Follow-up
Abstract
The present study investigated neuropsychological correlates of major depression and their course following treatment. We investigated 41 patients with major depression according to DSM-III-R criteria, who do not fulfil criteria of Alzheimer's disease, with a standardised clinical interview, different self- and observer-rating depression scales, and a comprehensive neuropsychological examination, and 27 subjects were reinvestigated 4.5 weeks after the first assessment. We found deficits in all cognitive domains with a predominant decline in tasks of cognitive flexibility and fluency. Patients who respond to antidepressive treatment showed a significant improvement in executive functions at the followup examination. Our data support the hypothesis that cognitive disorders in major depression may be associated with a frontostriatal dysfunction.
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There is also evidence suggesting that changes in cognitive function are associated with symptomatic improvement.
“there is also evidence suggesting that changes in cognitive function are associated with symptomatic improvement [15, 38, 39].”
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- Authors
- Beblo, T., Baumann, B., Bogerts, B., Wallesch, C.-W., & Herrmann, M.
- Venue
- Cognitive Neuropsychiatry
- Publisher
- Informa UK Limited
- Published
- 1999-10
- Volume
- 4
- Issue
- 4
- Pages
- 333-341
- ISSN
- 1354-6805 (ISSN-L)
- 1464-0619
- OpenAlex
- W2111005693
- Cited by
- 65
- References
- 33
- Citations by year
- 2026: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 5 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 8
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cognitive Neuropsychiatry (publishedVersion)
- PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, neuropsychological deficits, cognitive flexibility, fluency, executive function, antidepressant response, frontostriatal dysfunction, cognitive decline, short-term follow-up
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