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Cited by 60Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsIntensive Care Unit Cognitive Disorders

Agitation-associated behavioral symptoms in mild cognitive impairment and Alzheimer's dementia

Van der Mussele, Stefan, Le Bastard, Nathalie, Saerens, Jos, Somers, Nore, Mariën, Peter, Goeman, Johan, De Deyn, Peter P., Engelborghs, Sebastiaan·2015·Aging & Mental Health
DOI 10.1080/13607863.2014.924900
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Abstract

OBJECTIVES: The aim of this study is to determine the prevalence of agitation in mild cognitive impairment (MCI, Petersen's criteria) and patients with Alzheimer's dementia (AD), and to characterize the associated behavioral symptoms. METHOD: A cross-sectional analysis of baseline data from a prospective, longitudinal study on behavioral symptoms was performed, including 268 MCI and 393 AD patients. Behavioral assessment was performed through Middelheim Frontality Score (MFS), Behavioral Pathology in Alzheimer's Disease Rating Scale (Behave-AD) and Cornell Scale for Depression in Dementia (CSDD). Agitated behavior was considered to be clinically relevant when one or more items of the Cohen-Mansfield Agitation Inventory (CMAI) occurred at least once a week. RESULTS: The prevalence of agitation in AD (76%) was higher than in MCI (60%; p < 0.001). Patients with agitation showed more severe frontal lobe, behavioral and depressive symptoms (MFS, Behave-AD and CSDD total scores). In agitated AD patients, all behavioral symptoms and types of agitation were more severe compared to non-agitated AD patients, but in agitated MCI patients only for diurnal rhythm disturbances. This resulted in more severe Behave-AD global scores in patients with agitation as compared to patients without agitation. Comparing MCI and AD patients, MCI patients with agitation showed more severe behavioral and depressive symptoms than AD patients without agitation. The structure of agitation in AD consisted of more aggressive and physically non-aggressive behavior than in MCI. CONCLUSION: Frontal lobe, behavioral and depressive symptoms are more severe in MCI and AD patients with clinically relevant agitation as compared to patients without agitation. However, this association is less pronounced in MCI.

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  • Sleep abnormalities accelerate the accumulation of beta-amyloid and release of toxic tau in the brain, increasing the risk of dementia.

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  • Alzheimer's brain changes disrupt the sleep-wake cycle, leading to increased sleep fragmentation and wakefulness and decreased slow-wave sleep.

    “However, researchers have found that Alzheimer's brain changes disrupt the sleep‐wake cycle, leading to increased sleep fragmentation and wakefulness and decreased slow‐wave sleep.”

    From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [66]

  • Sleep problems may be bidirectional, with Alzheimer's disease increasing the risk of sleep disturbances and sleep disturbances increasing the risk of Alzheimer's.

    “In this way, sleep problems may be bidirectional, with Alzheimer's disease increasing the risk of sleep disturbances and sleep disturbances increasing the risk of Alzheimer's.”

    From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [66]

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Authors
Van der Mussele, S., Le Bastard, N., Saerens, J., Somers, N., Mariën, P., Goeman, J., De Deyn, P. P., & Engelborghs, S.
Affiliations
  • ZNA Middelheim Hospital (BE)
  • Vrije Universiteit Brussel (BE)
  • University of Antwerp (BE)
Corresponding author
Engelborghs, Sebastiaan
ORCID
Venue
Aging & Mental Health
Publisher
Informa UK Limited
Published
2014-06-25
Volume
19
Issue
3
Pages
247-257
ISSN
  • 1360-7863 (ISSN-L)
  • 1364-6915
DOI
10.1080/13607863.2014.924900
OpenAlex
W2046646298
Cited by
60
References
65
Citations by year
2026: 7 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 7 · 2016: 1 · 2015: 4
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Aging & Mental Health (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
  • H. Lundbeck A/S
  • Bijzonder Onderzoeksfonds UGent
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
agitation, mild cognitive impairment, Alzheimer's dementia, behavioral symptoms, depressive symptoms, aggression, Cohen-Mansfield Agitation Inventory
MeSH terms
Aged, Aged, 80 and over, Aggression, Alzheimer Disease, Behavioral Symptoms, Cross-Sectional Studies, Depression, Female, Humans, Male, Middle Aged, Psychomotor Agitation, Prevalence, Cognitive Dysfunction

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