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Cited by 39Hormonal and reproductive studiesSperm and Testicular FunctionAdrenal Hormones and Disorders

Age related variation of salivary testosterone values in healthy Japanese males

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Uchida, Akiko, Bribiescas, Richard G., Ellison, Peter T., Kanamori, Masao, Ando, Juko, Hirose, Nobuyoshi, Ono, Yutaka·2006·The Aging Male
DOI 10.1080/13685530601060461
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Abstract

OBJECTIVE: We examined age associated variation in salivary testosterone values among Japanese males as well as anthropometric measurements. METHODS: Salivary samples were collected in pretreated sodium azide treated tubes. The first series: 15-79-year-old males (n = 99); two morning and two evening samples were collected at home for two days. The second series: 90-year-old males (n = 29); one morning sample was collected. Testosterone values were determined using an iodine125-based radioimmunoassay kit modified for saliva. RESULTS: Results show 1) a significant decrease in salivary testosterone values from 20s to 40s and older, 2) no significant decline after 40 through 90 years old, 3) no significant age-related differences in the degree of intraindividual diurnal fluctuation across age groups of 40-70s, and 4) higher BMI is associated with the lower salivary testosterone among 40-70s. CONCLUSIONS: These results suggest that neither a constant decrease of salivary testosterone values or markedly reduced intraindividual fluctations are universal aspects of aging. Older males may maintain relatively high testosterone levels compared to younger men and a relatively 'robust' neuroendocrinological system.

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  • Serum testosterone levels continue to rise after puberty and peak in the third decade in male humans.

    “Interestingly, serum testosterone levels continue to rise after puberty and peak in the third decade in male humans (97).”

    From Emerging Adulthood, a Pre-adult Life-History Stage (2020) · cites this paper as [97]

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  1. Snyder PJ, Peachey H, Berlin JA, Loh L, Lenrow DA, Holmes JH, Dlewati A, Santanna J, Rosen CJ, Strom BL. Effect of testosterone on body composition and muscle strength in men over 65 year of age. J Clin Endocronol Metab 1999;84:2647- 2653.

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Authors
Uchida, A., Bribiescas, R. G., Ellison, P. T., Kanamori, M., Ando, J., Hirose, N., & Ono, Y.
Affiliations
  • Waseda University (JP)
  • Yale University (US)
  • Harvard University (US)
  • Biwako Seikei Sport College (JP)
  • Keio University (JP)
Corresponding author
Uchida, Akiko
ORCID
Venue
The Aging Male
Publisher
Informa UK Limited
Published
2006-01
Volume
9
Issue
4
Pages
207-213
ISSN
  • 1368-5538 (ISSN-L)
  • 1473-0790
DOI
10.1080/13685530601060461
OpenAlex
W2135387972
Cited by
39
References
51
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 3 · 2012: 1
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • The Aging Male (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Yale University
  • Harvard University
  • Waseda University
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
salivary testosterone, age-related decline, aging, diurnal variation, body mass index, healthy men, Japanese men, neuroendocrine system, androgen levels
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Humans, Japan, Male, Middle Aged, Saliva, Testosterone

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