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Cited by 315Hormonal and reproductive studiesSperm and Testicular FunctionAdipokines, Inflammation, and Metabolic Diseases

Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study

Derby, Carol A., Zilber, Sophia, Brambilla, Don, Morales, Knashawn H., McKinlay, John B.·2006·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2006.02560.x
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Abstract

Summary: Objective Cross‐sectional data suggest that obesity, particularly central obesity, may be associated with decreased production of sex steroid hormones in men. However, longitudinal hormone data on men in relation to obesity status are limited. Previous studies have not consistently demonstrated whether sex steroids are associated specifically to body mass index or to measures of central obesity. Our objective was to examine the relation of obesity (body mass index > 30 kg/m 2), and of central obesity (waist circumference > 100 cm or waist to hip ratio > 0·95) to longitudinal change in sex steroid hormones in men. Design Prospective follow‐up of a population‐based sample of men in Boston. Patients Nine hundred forty‐two (942) men in the Massachusetts Male Ageing Study with complete anthropometry and hormone data at baseline (1987–1989, ages 40–70) and follow‐up (1995–1997). Measurements Free and total testosterone (FT and TT), dehydroepiandrosterone sulphate (DHEAS), and sex hormone‐binding globulin (SHBG) were assessed using standardized methods. Health behaviours and medical history were obtained by structured interview. Repeated measures regression was used to describe trends in steroid hormones and SHBG in relation to obesity status, adjusting for age, smoking, alcohol, comorbidities, and physical activity. Results Obesity was associated with decreased levels of total and free testosterone, and of SHBG at follow‐up relative to baseline. For any given baseline concentration of TT, FT or SHBG, follow‐up levels were lowest among men who remained obese or who became obese during follow‐up. This was true for all three indices of obesity. Central adiposity was associated with lower DHEAS levels at follow‐up, while elevated body mass index was not. Conclusions Obesity may predict greater decline in testosterone and SHBG levels with age. Central adiposity may be a more important predictor of decline in DHEAS than is body mass index.

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  • Age, BMI, fasting blood glucose, triglycerides, alcohol consumption and estradiol levels have all been reported to be associated with alteration in hormone levels.

    “Age, 11,14-17 body mass index (BMI), 12 fasting blood glucose, 1,35 triglycerides, 36 alcohol consumption 13,14 and estradiol levels, 13 which have all been reported to be associated with alteration in hormone levels, were chosen as potential confounding factors in this study.”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [12]

  • Age, cigarette smoking, BMI, alcohol consumption and physical activity have been reported to be probably or possibly associated with hormone levels.

    “Probable and possible associations of several factors, including age, cigarette smoking, body mass index (BMI), alcohol consumption and physical activity with hormone levels have been reported. 11-17”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [12]

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Authors
Derby, C. A., Zilber, S., Brambilla, D., Morales, K. H., & McKinlay, J. B.
Affiliations
  • Albert Einstein College of Medicine (US)
  • New England Research Institutes (US)
  • University of Pennsylvania (US)
Corresponding author
Derby, Carol A.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2006-06-08
Volume
65
Issue
1
Pages
125-131
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2006.02560.x
OpenAlex
W2042336125
Cited by
315
References
4
Citations by year
2026: 3 · 2025: 5 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 16 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 24 · 2016: 14 · 2015: 22 · 2014: 19 · 2013: 20 · 2012: 16
FWCI
12.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG 04673, P01AG004673)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
obesity, abdominal obesity, body mass index, waist circumference, waist-to-hip ratio, sex hormones, testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, men
MeSH terms
Adult, Aged, Aging, Anthropometry, Body Constitution, Health Surveys, Humans, Longitudinal Studies, Male, Massachusetts, Middle Aged, Obesity, Prospective Studies, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone, Body Mass Index, Multivariate Analysis, Dehydroepiandrosterone Sulfate, Waist-Hip Ratio

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