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Estrogens and the skin

Brincat, MP, Muscat Baron, Y, Galea, R·2005·Climacteric
DOI 10.1080/13697130500118100
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Abstract

Objective A review of the medical literature concerning the effect of the menopause and its hormonal treatment on the skin. Methods An extensive Medline and Pubmed internet search utilizing the key words: collagen, elastin, estrogen, hormone replacement therapy, skin and aging. Results The literature review demonstrated a wide array of research ranging from basic science work to clinical implications of the effects of the menopause and its treatment on the skin. Conclusion Estrogen loss at menopause has a profound influence on skin. Estrogen treatment in postmenopausal women has been repeatedly shown to increase collagen content, dermal thickness and elasticity, and data on the effect of estrogen on skin water content are also promising. Further, physiologic studies on estrogen and wound healing suggest that hormone replacement therapy (HRT) may play a beneficial role in cutaneous injury repair. Results on the effect of HRT on other physiologic characteristics of skin, such as elastin content, sebaceous secretions, wrinkling and blood flow, are discordant. Given the responsiveness of skin to estrogen, the effects of HRT on aging skin require further examination, and careful molecular studies will likely clarify estrogen's effects at the cellular level.

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  • 30% of skin collagen is lost in the first five postmenopausal years, with an average decline of 2% per year over a period of 15 years.

    “Brincat et al. (2005) also concluded, based on a wide literature review, that 30% of skin collagen is lost in the first five postmenopausal years, with an average decline of 2 % per year over a period of 15 years.”

    From Facial aging trajectories: A common shape pattern in male and female faces is disrupted after menopause (2019) · cites this paper as Brincat et al. (2005)

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Metadata

Authors
Brincat, M., Muscat Baron, Y., & Galea, R.
Affiliations
Department of Obstetrics and Gynaecology, University of Malta Medical School, St. Luke's Hospital, Malta
Venue
Climacteric
Publisher
Informa UK Limited
Published
2005-06
Volume
8
Issue
2
Pages
110-123
ISSN
  • 1369-7137
  • 1473-0804
DOI
10.1080/13697130500118100
Cited by
160
References
3
Language
en

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