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Cited by 111Thermoregulation and physiological responsesMenopause: Health Impacts and TreatmentsCardiovascular and exercise physiology

Chronic hormone replacement therapy alters thermoregulatory and vasomotor function in postmenopausal women

Brooks, E. M., Morgan, A. L., Pierzga, J. M., Wladkowski, S. L., O’Gorman, J. T., Derr, J. A., Kenney, W. L.·1997·Journal of Applied Physiology
DOI 10.1152/jappl.1997.83.2.477
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Abstract

Brooks, E. M., A. L. Morgan, J. M. Pierzga, S. L. Wladkowski, J. T. O’Gorman, J. A. Derr, and W. L. Kenney. Chronic hormone replacement therapy alters thermoregulatory and vasomotor function in postmenopausal women. J. Appl. Physiol. 83(2): 477–484, 1997.—This investigation examined effects of chronic (≥2 yr) hormone replacement therapy (HRT), both estrogen replacement therapy (ERT) and estrogen plus progesterone therapy (E+P), on core temperature and skin blood flow responses of postmenopausal women. Twenty-five postmenopausal women [9 not on HRT (NO), 8 on ERT, 8 on E+P] exercised on a cycle ergometer for 1 h at an ambient temperature of 36°C. Cutaneous vascular conductance (CVC) was monitored by laser-Doppler flowmetry, and forearm vascular conductance (FVC) was measured by using venous occlusion plethysmography. Iontophoresis of bretylium tosylate was performed before exercise to block local vasoconstrictor (VC) activity at one skin site on the forearm. Rectal temperature (T re) was ∼0.5°C lower for the ERT group ( P < 0.01) compared with E+P and NO groups at rest and throughout exercise. FVC: mean body temperature (T b) and CVC: T b curves were shifted ∼0.5°C leftward for the ERT group ( P < 0.0001). Baseline CVC was significantly higher in the ERT group ( P < 0.05), but there was no interaction between bretylium treatment and groups once exercise was initiated. These results suggest that 1) chronic ERT likely acts centrally to decrease T re, 2) ERT lowers the T re at which heat-loss effector mechanisms are initiated, primarily by actions on active cutaneous vasodilation, and 3) addition of exogenous progestins in HRT effectively blocks these effects.

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Crossref · 10.1152/jappl.1997.83.2.477

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  • Addition of progestins blocked the temperature-lowering effect of estrogen such that core body temperatures were similar to those of women not taking any hormone replacement therapy.

    “Addition of progestins blocked the temperature-lowering effect of estrogen such that core body temperatures were similar to those of women not taking any hormone replacement therapy [103].”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [103]

  • Estrogen replacement therapy in postmenopausal women reduces resting rectal temperature by ~0.5°C.

    “Also, studies of the effects of estrogen replacement therapy in postmenopausal women show a reduction in resting rectal temperature (by ~0.5°C) [103,104].”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [103]

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Authors
Brooks, E. M., Morgan, A. L., Pierzga, J. M., Wladkowski, S. L., O’Gorman, J. T., Derr, J. A., & Kenney, W. L.
Affiliations
  • Noll Physiological Research Center and
  • Statistical Consulting Center, Pennsylvania State University, University Park, Pennsylvania 16802
  • Pennsylvania State University (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1997-08-01
Volume
83
Issue
2
Pages
477-484
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1997.83.2.477
OpenAlex
W2187872006
Cited by
111
References
41
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 1 · 2013: 4 · 2012: 2
FWCI
2.85
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG007004, R01-AG07004-07)
  • National Center for Research Resources (M01-RR10732-01, M01RR010732)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
hormone replacement therapy, estrogen replacement therapy, postmenopausal women, thermoregulation, core body temperature, skin blood flow, cutaneous vascular conductance, forearm vascular conductance, exercise thermoregulation, vasoconstriction, progestins, heat loss
MeSH terms
Body Temperature, Body Temperature Regulation, Drug Combinations, Estrogens, Female, Hot Temperature, Humans, Middle Aged, Progesterone, Regional Blood Flow, Skin, Stress, Physiological, Time Factors, Vasomotor System, Exercise, Estrogen Replacement Therapy, Postmenopause

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