A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part I: Cellular and molecular perspectives of skin ageing

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Photoaging is Associated with Protein Oxidation in Human Skin In Vivo

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Modulation of Skin Collagen Metabolism in Aged and Photoaged Human Skin In Vivo

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Theories of biological aging: Genes, proteins, and free radicals

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Telomeres: Cancer to Human Aging

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Nitric oxide function in the skin

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Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

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Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases

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Molecular Mechanisms of Photoaging and its Prevention by Retinoic Acid: Ultraviolet Irradiation Induces MAP Kinase Signal Transduction Cascades that Induce Ap-1-Regulated Matrix Metalloproteinases that Degrade Human Skin In Vivo

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Is the Mitochondrial Free Radical Theory of Aging Intact?

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Telomere dysfunction as a cause of genomic instability in Werner syndrome

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Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways

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Vitamin E Mediates Cell Signaling and Regulation of Gene Expression

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Cutaneous Effects of Smoking

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UV-Induced Oxidative Stress and Photoaging

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Diagnosis and treatment of cutaneous melanoma: state of the art 2006*

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Biology of estrogens in skin: implications for skin aging

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Matrix metalloproteinase-1 and skin ageing in smokers

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Smoking affects collagen synthesis and extracellular matrix turnover in human skin

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γ-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

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The effects on human health from stratospheric ozone depletion and its interactions with climate change

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The biochemistry of aging

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Alterations of extracellular matrix induced by tobacco smoke extract

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Hutchinson–Gilford progeria syndrome

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Oxidative phosphorylation and aging

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Molecular bases of progeroid syndromes

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What Can Progeroid Syndromes Tell Us About Human Aging?

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Estrogens and the skin

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Energy Metabolism and Oxidative Stress: Impact on the Metabolic Syndrome and the Aging Process

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Aging of Hutchinson–Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

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Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies

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Vitamins as Hormones

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Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicine

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Cigarette smoking associated with premature facial wrinkling: image analysis of facial skin replicas

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Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival

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Inflammatory mediator and β-amyloid (25–35)-induced ceramide generation and iNOS expression are inhibited by vitamin E

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Non‐enzymatic triggering of the ceramide signalling cascade by solar UVA radiation

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The pathophysiology of photoaging of the skin.

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Sunlight, Immunosuppression And Skin Cancer: Role Of Histamine And Mast Cells

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Influence of Age on the Lips and Perioral Skin

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Cutaneous Effects of Smoking

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Exogenous factors in skin aging

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Caloric Restriction, Metabolic Rate, and Entropy

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Longevity genes: from primitive organisms to humans

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Acute skin failure: Concept, causes, consequences and care

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Oxidative Damage and Aging: Spotlight on Mitochondria

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Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective

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Hormetic prevention of molecular damage during cellular aging of human skin fibroblasts and keratinocytes

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Tobacco smoke extract induces age‐related changes due to modulation of TGF‐β

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Nuclear Hormone Receptors in Human Skin

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The human telomere and its relationship to human disease, therapy, and tissue engineering

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Genes, telomeres and mammalian ageing

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Genetic alterations in accelerated ageing syndromes

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‘Skin Failure’–A Real Entity: Discussion Paper

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Levels of matrix metalloproteinase-2, −9 and −8 in the skin, serum and saliva of smokers and non-smokers

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Public knowledge, awareness, and perceptions of the association between skin aging and smoking

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Effects of diet and age on oxidative damage products in healthy subjects

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Pro-oxidant and anti-oxidant mechanism s of BHT and b-carotene in photocarcinogenesis

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The Role of Microglial Cellular Senescence in the Aging and Alzheimer Diseased Brain

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Progress and Prospects on Melanoma: The Way Forward for Early Detection and Reduced Mortality

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Studies in Vitamin E: Biochemistry and Molecular Biology of Tocopherol Quinones

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Helicases and aging

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Relationships between changes in mechanical properties of the skin, wrinkling, and destruction of dermal collagen fiber bundles caused by photoaging

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Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging

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Unhealthy lifestyles during the life course: association with physical decline in late life

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Hypothesis: Werner syndrome and biological ageing: A molecular genetic hypothesis

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CELL GROWTH REGULATION

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Telomeres

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Extension of Cell Life Span Using Exogenous Telomerase

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Improving cell therapy—experiments using transplanted telomerase-immortalized cells in immunodeficient mice

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Photoimmunology—illuminating the immune system through photobiology

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The molecular basis of ageing in stem cells

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From dermal exposure to internal dose

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Hypothesis: Lifespan is Regulated by Chronomere DNA of the Hypothalamus

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Topical and oral estrogens revisited for antiaging purposes

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Too fast by mistake

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Targeting Telomerase

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Is cell death and replacement a factor in aging?

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Peripheral arterial disease: diagnosis, treatment, and systemic implications

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Cutaneous gene therapy

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Peripheral Arterial Disease

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Inducing Cellular Senescence Using Defined Genetic Elements

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Ageing: Repair and Transcription Keep Us from Premature Ageing

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Diet and Skin Aging—From the Perspective of Food Nutrition

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Mechanical properties of human skin <i>in vivo</i>: a comparative evaluation in 300 men and women

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Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

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Revisiting carotenoids as dietary antioxidants for human health and disease prevention

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Age‐related dermal collagen changes during development, maturation and ageing – a morphometric and comparative study

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Skin Ageing: Natural Weapons and Strategies

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Age‐related changes in skin barrier function – Quantitative evaluation of 150 female subjects

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Effects of blue light irradiation on human dermal fibroblasts

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Using Copper to Improve the Well-Being of the Skin

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Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging

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Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging

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Scarless wound healing: From development to senescence

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Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin

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Release and in vitro skin permeation of polyphenols from cosmetic emulsions

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Optical Microscopy and the Extracellular Matrix Structure: A Review

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A brief review on emerging trends in global polyphenol research

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Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice

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Investigating skin penetration depth and shape following needle‐free injection at different pressures: A cadaveric study

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Olive Tree in Circular Economy as a Source of Secondary Metabolites Active for Human and Animal Health Beyond Oxidative Stress and Inflammation

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(+)-Catechin protects dermal fibroblasts against oxidative stress-induced apoptosis

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Coenzyme Q10 protects against oxidative stress‐induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells

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Collagen and Elastic Content of Abdominal Skin After Surgical Weight Loss

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Aging in the Male Face: Intrinsic and Extrinsic Factors

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Skin Protective Effects of Nannochloropsis gaditana Extract on H2O2-Stressed Human Dermal Fibroblasts

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Main approaches for delivering antioxidant vitamins through the skin to prevent skin ageing

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MicroRNAs in human skin ageing

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Quantification of Age-Related Facial Wrinkles in Men and Women Using a Three-Dimensional Fringe Projection Method and Validated Assessment Scales

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Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid

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The impact of noncoding RNA on the biochemical and molecular mechanisms of aging

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Role of proteoglycans on skin ageing: a review

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Aging enhances maceration-induced ultrastructural alteration of the epidermis and impairment of skin barrier function

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From heterochromatin islands to the NAD World: A hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis

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A comprehensive review of the molecular mechanisms driving skin photoaging and the recent advances in therapeutic interventions involving natural polyphenols

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Restoring Skin Hydration and Barrier Function: Mechanistic Insights Into Basic Emollients for Xerosis Cutis

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Evaluation of collagen alteration after topical photodynamic therapy (PDT) using second harmonic generation (SHG) microscopy – in vivo study in a mouse model

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Extracellular matrix at the muscle – tendon interface: functional roles, techniques to explore and implications for regenerative medicine

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NADPH oxidase‐2 is a key regulator of human dermal fibroblasts: a potential therapeutic strategy for the treatment of skin fibrosis

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Factores intrínsecos y extrínsecos implicados en el envejecimiento cutáneo

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Implications of Aging in Plastic Surgery

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A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis

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Aging-Like Skin Changes Induced by Ultraviolet Irradiation in an Animal Model of Metabolic Syndrome

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Synthesis of lipoic acid–peptide conjugates and their effect on collagen and melanogenesis

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An updated review of clinical methods in the assessment of ageing skin – New perspectives and evaluation for claims support

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Role of oxidative stress in skin aging

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Proteomic profiling reveals a catalogue of new candidate proteins for human skin aging

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The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial

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Microphysiological systems for human aging research

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A study on the alterations in skin viscoelasticity before and after an intradermal administration of growth factor

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Abdominal Wall Reconstruction Using Biological Tissue Grafts

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GABA promotes elastin synthesis and elastin fiber formation in normal human dermal fibroblasts (HDFs)

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In vitro protective effects of marine-derived Aspergillus puulaauensis TM124-S4 extract on H2O2-stressed primary human fibroblasts

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A clinical trial shows improvement in skin collagen, hydration, elasticity, wrinkles, scalp, and hair condition following 12-week oral intake of a supplement containing hydrolysed collagen

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Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

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Interaction networks as a tool to investigate the mechanisms of aging

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Understanding Skin Failure: A Scoping Review

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Comparison of 2 Hyaluronic Acid-based Fillers for the Treatment of Acne Scars: Structural Lifting Versus Biostimulatory Effect

Mehrabi, J. N., Shehadeh, W., Gallo, E. S., Artzi, O., & Horovitz, T. (2023) · Dermatologic Surgery · doi:10.1097/dss.0000000000003789 · Cited by 17 · see citing works

Obesity and type 2 diabetes mellitus: insights from skeletal muscle extracellular matrix remodeling

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Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing

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Beauty from within: Improvement of skin health and appearance with Lycomato a tomato‐derived oral supplement

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D-limonene attenuates D-galactose-induced skin aging mouse model

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Cecropia pachystachyaLeaves Present Potential to Be Used as New Ingredient for Antiaging Dermocosmetics

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Skin Cancer, Polyphenols, and Oxidative Stress

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Evaluation of ultrasonography for measurement of skin thickness in Shar-Peis

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Treatment of periocular wrinkles with topical nifedipine

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Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract

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Anti-aging potential of Cephalotaxus harringtonia extracts: the role of harringtonine and homoharringtonine in skin protection

Ahn, S.-Y., Lee, C.-D., Ku, J., Lee, S., & Lee, S. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00951-1 · Cited by 12 · see citing works

Fluorescence Lifetime Imaging of the Skin

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The relationship between skin aging and steady state ultraweak photon emission as an indicator of skin oxidative stress in vivo

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Altered vimentin protein expression in human dermal microvascular endothelial cells after ultraviolet or intense pulsed light treatment

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A systematic study on herbal cream for various clinical and therapeutic application: current status and future prospects

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Dermal delivery of ascorbyl palmitate: the potential of colloidal delivery systems

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Strategies for future histocompatible stem cell therapy

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Pathology of Aging Skin

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Facial Skin Lifting and Brightening Following Sleep on Copper Oxide Containing Pillowcases

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In vivo topical application of acetyl aspartic acid increases fibrillin‐1 and collagen IV deposition leading to a significant improvement of skin firmness

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Advantages of Functional Foods in Supporting and Maintaining Hair and Skin Health

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The influence of ethnic origin on the skin photoageing: Nepalese study

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Novel Chitosan Dermal Filler with Enhanced Moldability and Elasticity

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Molecular diagnostic strategies: a role in the practice of dermatology

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Structural activity relationship analysis (SAR) and in vitro testing reveal the anti‐ageing potential activity of acetyl aspartic acid

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Repeated short climatic change affects the epidermal differentiation program and leads to matrix remodeling in a human organotypic skin model

Barbollat‐Boutrand, L., Thepot, A., Muther, C., Boher, A., Robic, J., Guéré, C., Vié, K., Damour, O., & Lamartine, J. (2017) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s120800 · Cited by 6 · see citing works

Molecular Aspects of Skin Aging

Murphy, M. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-171-4_20 · Cited by 6 · see citing works

Correlation Between External and Internal Skin Aging Markers by Skin Depth

Yang, H., Park, S., Woo, J., & Park, B. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70354 · Cited by 5 · see citing works

pep_35E7UW, a natural peptide with cutaneous anti-ageing effects discovered within the Oryza sativa proteome through machine learning

Wall, A. M. (2020) · Journal of Dermatology & Cosmetology · doi:10.15406/jdc.2020.04.00162 · Cited by 5 · see citing works

Autologer Fett- und Bluttransfer

Bioulac, B., Heppt, W. J., & Heppt, M. V. (2015) · HNO · doi:10.1007/s00106-015-0033-6 · Cited by 5 · see citing works

Evaluation of subclinical chronic sun damage in the skin via the detection of long‐lasting ultraweak photon emission

Gabe, Y., Takeda, K., Tobiishi, M., Kikuchi, S., Tsuda, K., Haryuu, Y., Nakajima, Y., Inomata, Y., Nakamura, S., Murase, D., et al. (2021) · Skin Research and Technology · doi:10.1111/srt.13059 · Cited by 5 · see citing works

Full Thickness Skin Expansion ex vivo in a Newly Developed Reactor and Evaluation of Auto-Grafting Efficiency of the Expanded Skin Using Yucatan Pig Model

Huh, M., Yi, S., Lee, K.-P., Kim, H. K., An, S., Kim, D., Ryu, R.-H., Kim, J.-S., & Lim, J. O. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0154-6 · Cited by 5 · see citing works

Pathology of Aging Skin

Jia, Q., & Nash, J. F. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_28 · Cited by 4 · see citing works

Skin Aging and Cellulite in Women

Lorencini, M., Camozzato, F. O., & Hexsel, D. M. (2016) · Springer eBooks · doi:10.1007/978-3-642-27814-3_160-3 · Cited by 4 · see citing works

Exploratory study using proton induced X-ray emission analysis and histopathological techniques to determine the toxic burden of environmental pollutants

Ejaz, S., Ashraf, M. A., Shakir, L., & Ahmad, N. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2012.07.018 · Cited by 4 · see citing works

“Skin cancer, polyphenols, and oxidative stress” or Counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols

Philips, N. E., Richardson, R., Siomyk, H., Bynum, D., & González, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819547-5.00039-0 · Cited by 4 · see citing works

Age-Related Changes in Skin Mechanical Properties

Krueger, N., & Luebberding, S. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_116 · Cited by 4 · see citing works

New and revisited approaches on the transdermal delivery of polyphenols-loaded nanoparticles for melanoma prevention and treatment

Pontes, J. F., Fonseca, M., Macedo, A. S., Grenha, A., & Fonte, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99125-4.00001-9 · Cited by 3 · see citing works

Skin Aging: An Immunohistochemical Evaluation

El-Domyati, M. M., & Medhat, W. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_121-1 · Cited by 3 · see citing works

High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2

San, I. V. L. C., Prost, G., Williams, J. A. E., Moss, S. E., & Nuber, U. A. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.102 · Cited by 3 · see citing works

Molecular Mechanisms of Skin Aging and Rejuvenation

Kim, M., & Park, H. J. (2016) · InTech eBooks · doi:10.5772/62983 · Cited by 55 · see citing works

Focus on the Contribution of Oxidative Stress in Skin Aging

Papaccio, F., D’Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 431 · see citing works

Oxidative Stress and Human Skin Connective Tissue Aging

Tu, Y., & Quan, T. (2016) · Cosmetics · doi:10.3390/cosmetics3030028 · Cited by 114 · see citing works

Skin ageing

Kohl, E. A., Steinbauer, J., Landthaler, M., & Szeimies, R. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03963.x · Cited by 443 · see citing works

Editorial

Scharffetter‐­Kochanek, K. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00906.x · Cited by 9 · see citing works