The relationship between chronic physical conditions, multimorbidity and anxiety in the general population: a global perspective across 42 countries
Open accessAbstract
Objective This cross-sectional study assessed the association of chronic physical conditions and multimorbidity with anxiety among community-dwelling adults in 42 countries. Method Data were analyzed from the World Health Survey including 181,845 adults aged ≥18years. Anxiety in the past 30days and nine chronic physical conditions (angina, arthritis, asthma, chronic back pain, diabetes, edentulism, hearing problem, tuberculosis, and visual impairment) were assessed. Multivariable logistic regression analyses were conducted to explore the associations between chronic physical conditions or the number of them and anxiety. Results After adjustment for confounders, most of the individual chronic physical conditions were significantly associated with anxiety. Compared to those with no physical health conditions, one condition was associated with an almost twofold increased odds of anxiety symptoms (OR=1.94; 95%CI=1.76-2.13), while this figure rose to 5.49 (3.73-8.09) in those with ≥5 conditions. Conclusions Our data suggest that increasing numbers of chronic physical conditions are associated with higher odds for anxiety. Health care providers should consider the presence of anxiety symptoms especially in individuals with physical multimorbidity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Antipsychotic medication induced weight loss pathways include H1, D2, 5HT2c blockade, and dysregulation of GLP-1.
“Antipsychotic medication induced weight loss pathways include H1, D2, 5HT2c blockade, and dysregulation of GLP-1 152,153 .”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [152]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Barnett, K., Mercer, S. W., Norbury, M., Watt, G., Wyke, S., & Guthrie, B. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60240-2 · Cited by 6,972 · see citing works
Kessler, R. C., & Üstün, T. B. (2004) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.168 · Cited by 4,771 · see citing works
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
The burden and costs of chronic diseases in low-income and middle-income countries.
Abegunde, D. O., Mathers, C. D., Adam, T., Ortegon, M., & Strong, K. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61696-1 · Cited by 1,603 · cited 1× · see citing works
“This is an important research gap, given the increasing prevalence of chronic physical health conditions globally, and especially in low- and middle-income countries [26].”
BackgroundGlobal prevalence of anxiety disorders: a systematic review and meta-regression
Baxter, A. J., Scott, K. M., Vos, T., & Whiteford, H. A. (2013) · Psychological Medicine · doi:10.1017/s003329171200147x · Cited by 1,537 · see citing works
Scaling-up treatment of depression and anxiety: a global return on investment analysis
Chisholm, D., Sweeny, K., Sheehan, P., Rasmussen, B., Smit, F., Cuijpers, P., & Saxena, S. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30024-4 · Cited by 1,451 · see citing works
The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.
Rose, G. A. (1962) · Europe PMC (PubMed Central) · Cited by 1,328 · see citing works
A Systematic Review of Prevalence Studies on Multimorbidity: Toward a More Uniform Methodology
Fortin, M., Stewart, M., Poitras, M.-È., Almirall, J., & Maddocks, H. L. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1337 · Cited by 1,131 · see citing works
Multimorbidity and quality of life in primary care: a systematic review
Fortin, M., Lapointe, L., Hudon, C., Vanasse, A., Ntetu, A. L., & Maltais, D. (2004) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-2-51 · Cited by 963 · see citing works
Lai, H. M. X., Cleary, M., Sitharthan, T., & Hunt, G. E. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.031 · Cited by 941 · see citing works
Quality of life in the anxiety disorders: a meta-analytic review
Olatunji, B. O., Cisler, J. M., & Tolin, D. F. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.01.015 · Cited by 808 · see citing works
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772 · see citing works
The global burden of anxiety disorders in 2010
Baxter, A. J., Vos, T., Scott, K. M., Ferrari, A. J., & Whiteford, H. A. (2014) · Psychological Medicine · doi:10.1017/s0033291713003243 · Cited by 768 · cited 1× · see citing works
“Anxiety disorders are the sixth leading global cause of years lived with disability [5].”
BackgroundPsychological adjustment to chronic disease
de Ridder, D., Geenen, R., Kuijer, R., & van Middendorp, H. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61078-8 · Cited by 759 · see citing works
Review: Health Care Utilization and Costs of Elderly Persons With Multiple Chronic Conditions
Lehnert, T., Heider, D., Leicht, H., Heinrich, S., Corrieri, S., Luppa, M., Riedel-Heller, S. G., & König, H. (2011) · Medical Care Research and Review · doi:10.1177/1077558711399580 · Cited by 753 · see citing works
Association of Mental Disorders With Subsequent Chronic Physical Conditions
Scott, K. M., Lim, C. C. W., Al-Hamzawi, A., Alonso, J., Bruffaerts, R., Caldas‐de‐Almeida, J. M., Florescu, S., de Girolamo, G., Hu, C., de Jonge, P., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2688 · Cited by 607 · see citing works
Scott, K. M., Bruffaerts, R., Tsang, A., Ormel, J., Alonso, J., Angermeyer, M. C., Benjet, C., Bromet, E., de Girolamo, G., de Graaf, R., et al. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.015 · Cited by 529 · see citing works
Multimorbidity in primary care: prevalence and trend over the last 20 years
Uijen, A. A., & van de Lisdonk, E. H. (2008) · European Journal of General Practice · doi:10.1080/13814780802436093 · Cited by 505 · see citing works
Anxiety disorders and inflammation in a large adult cohort
Vogelzangs, N., Beekman, A. T. F., de Jonge, P., & Penninx, B. W. J. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.27 · Cited by 458 · see citing works
Association of diabetes with anxiety: a systematic review and meta-analysis
Smith, K. J., Béland, M., Clyde, M., Gariépy, G., Pagé, V., Badawi, G., Rabasa-Lhoret, R., & Schmitz, N. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.11.013 · Cited by 447 · see citing works
The Effect of Exercise Training on Anxiety Symptoms Among Patients: A Systematic Review
Herring, M. P. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.530 · Cited by 446 · see citing works
Human and economic burden of generalized anxiety disorder
Hoffman, D. L., Dukes, E. M., & Wittchen, H.-U. (2008) · Depression and Anxiety · doi:10.1002/da.20257 · Cited by 438 · see citing works
Bidirectional Associations Between Clinically Relevant Depression or Anxiety and COPD
Atlantis, E., Fahey, P., Cochrane, B., & Smith, S. (2013) · Chest · doi:10.1378/chest.12-1911 · Cited by 354 · see citing works
The Continuum of Psychotic Symptoms in the General Population: A Cross-national Study
Nuevo, R., Chatterji, S., Verdes, E., Naidoo, N., Arango, C., & Ayuso-Mateos, J. L. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq099 · Cited by 340 · see citing works
Meta-Analysis of Anxiety as a Risk Factor for Cardiovascular Disease
Emdin, C. A., Odutayo, A., Wong, C. X., Tran, J., Hsiao, A. J., & Hunn, B. H. M. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.05.041 · Cited by 329 · see citing works
Multimorbidity: redesigning health care for people who use it
Salisbury, C. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60482-6 · Cited by 326 · see citing works
Major Depressive and Anxiety Disorders in Visually Impaired Older Adults
van der Aa, H. P. A., Comijs, H. C., Penninx, B. W. J. H., van Rens, G. H. M. B., & van Nispen, R. M. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15848 · Cited by 279 · see citing works
The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review
Haller, H., Cramer, H., Lauche, R., Gass, F., & Dobos, G. J. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-128 · Cited by 267 · see citing works
HPA axis activity in patients with panic disorder: review and synthesis of four studies
Abelson, J. L., Khan, S. A., Liberzon, I., & Young, E. A. (2006) · Depression and Anxiety · doi:10.1002/da.20220 · Cited by 224 · see citing works
Koyanagi, A., & Stickley, A. (2015) · Sleep · doi:10.5665/sleep.5232 · Cited by 188 · see citing works
Self-citationRayner, L., Matcham, F., Hutton, J., Stringer, C., Dobson, J., Steer, S. E., & Hotopf, M. H. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.12.004 · Cited by 137 · see citing works
Goldhaber‐Fiebert, J. D., Jeon, C. Y., Cohen, T., & Murray, M. B. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyq238 · Cited by 132 · see citing works
The association of major depressive episodes with income inequality and the human development index.
Cifuentes, M., Sembajwe, G. N., Tak, S., Gore, R., Kriebel, D., & Punnett, L. (2008) · Social Science & Medicine (1967) · doi:10.1016/j.socscimed.2008.04.003 · Cited by 130 · see citing works
Comorbidity of pain and anxiety disorders
Gureje, O. (2008) · Current Psychiatry Reports · doi:10.1007/s11920-008-0051-0 · Cited by 125 · see citing works
Multimorbidity is associated with anxiety in older adults in the Health and Retirement Study
Gould, C. E., O'Hara, R. M., Goldstein, M. K., & Beaudreau, S. A. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4532 · Cited by 123 · see citing works
Gallo, J. J., Hwang, S., Joo, J. H., Bogner, H. R., Morales, K. H., BRUCE, M. L., & Reynolds, C. F. (2015) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3524-y · Cited by 104 · see citing works
Hiles, S. A., Révész, D., Lamers, F., Giltay, E. J., & Penninx, B. W. J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22512 · Cited by 103 · see citing works
Association of Hearing Impairment and Anxiety in Older Adults
Contrera, K. J., Betz, J., Deal, J. A., Choi, J. S., Ayonayon, H. N., Harris, T. B., Helzner, E., Martin, K. R., Mehta, K. M., Pratt, S. R., et al. (2016) · Journal of Aging and Health · doi:10.1177/0898264316634571 · Cited by 102 · see citing works
The Global Burden of Visual Difficulty in Low, Middle, and High Income Countries
Freeman, E. E., Roy‐Gagnon, M., Samson, E., Haddad, S. H. S., Aubin, M., Vela, C., & Zunzunegui, M. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063315 · Cited by 94 · see citing works
Loerbroks, A., Herr, R. M., Subramanian, S. V., & Bosch, J. A. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys123 · Cited by 83 · see citing works
Wong, K. O., Rowe, B. H., Douwes, J. E., & Senthilselvan, A. (2013) · Pulmonary Medicine · doi:10.1155/2013/929028 · Cited by 81 · see citing works
A study of prevalence of depression and anxiety in patients suffering from tuberculosis
Kumar, K., Kumar, A., Chandra, P., & Kansal, H. M. (2016) · Journal of Family Medicine and Primary Care · doi:10.4103/2249-4863.184641 · Cited by 61 · see citing works
Koyanagi, A., Oh, H. Y., Stickley, A., Haro, J. M., & DeVylder, J. (2016) · Psychological Medicine · doi:10.1017/s0033291716001422 · Cited by 53 · see citing works
Self-citationMoshier, S. J., Szuhany, K. L., Hearon, B. A., Smits, J. A. J., & Otto, M. W. (2015) · Behavior Modification · doi:10.1177/0145445515603704 · Cited by 49 · see citing works
Jiang, F., Li, S., Pan, L., Zhang, N., & Jia, C. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.10.022 · Cited by 39 · see citing works
Comorbid depression/anxiety and teeth removed: Behavioral Risk Factor Surveillance System 2010
Wiener, R. C., Wiener, M. A., & McNeil, D. W. (2015) · Community Dentistry And Oral Epidemiology · doi:10.1111/cdoe.12168 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Marcos de Souza Moura A, Khede Lamego M, Paes F, Ferreira Rocha NB, Simoes-Silva V, Almeida Rocha S, et al. Effects of aerobic exercise on anxiety disorders: a systematic review. CNS Neurol Disord-Drug Targ 2015;14:1184-1193.
- Craske MG and Stein MB. Anxiety. Lancet 2016; doi: 10.1016/S0140-6736(16)30381- 6.. · DOI · Paper page
- Barnett K, Mercer SW, Norbury M, Watt G, Wyke S and Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross- sectional study. Lancet 2012;380:37-43.
Cited by
Sorted by citations
Stubbs, B., Vancampfort, D., Firth, J., Schuch, F. B., Hallgren, M., Smith, L., Gardner, B., Kahl, K. G., Veronese, N., Solmi, M., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.104 · Cited by 138 · see citing works
van Dalen, M., Dierckx, B., Pasmans, S. G. M. A., Aendekerk, E. W. C., Mathijssen, I. M. J., Koudstaal, M. J., Timman, R., Williamson, H., Hillegers, M. H. J., Utens, E. M. W. J., et al. (2020) · Body Image · doi:10.1016/j.bodyim.2020.02.006 · Cited by 44 · see citing works
- Authors
- Vancampfort, D., Koyanagi, A., Hallgren, M., Probst, M., & Stubbs, B.
- Affiliations
- KU Leuven (BE)
- Instituto de Salud Carlos III (ES)
- Karolinska Institutet (SE)
- National Health Service (GB)
- Corresponding author
- Vancampfort, Davy
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 45
- Pages
- 1-6
- ISSN
- 0163-8343 (ISSN-L)
- OpenAlex
- W2555016136
- Cited by
- 108
- References
- 47
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 15 · 2022: 13 · 2021: 14 · 2020: 15 · 2019: 6 · 2018: 12 · 2017: 8
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- chronic physical illness, multimorbidity, anxiety, anxiety symptoms, community-dwelling adults, arthritis, diabetes mellitus, chronic back pain, asthma, tuberculosis, visual impairment, hearing loss, edentulism, cross-national comparison
- MeSH terms
- Multiple Chronic Conditions, Multimorbidity, Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Global Health, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review