Attenuating effect of bioactive coumarins from Convolvulus pluricaulis on scopolamine-induced amnesia in mice
Abstract
Jai Malika, Maninder Karana & Karan Vasishta*a University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India* Corresponding author. Email: kvasisht@hotmail.comConvolvulus pluricaulis Chois. (Convolvulaceae) has been used in Ayurveda as Medhya Rasyana (nervine tonic) to treat various mental disorders. This study was designed to isolate the bioactive compound(s) of this plant and to evaluate their effect against scopolamine-induced amnesia. Column chromatography of the chloroform and ethyl-acetate fractions led to the isolation of three coumarins identified as scopoletin, ayapanin and scopolin. All the three compounds at 2.5, 5, 10 and 15 mg/kg, p.o. were evaluated for memory-enhancing activity against scopolamine-induced amnesia using elevated plus maze and step down paradigms. Effect on acetylcholinesterase activity in mice brain was also evaluated. Scopoletin and scopolin, in both the paradigms, significantly and dose dependently attenuated the scopolamine-induced amnesic effect. Furthermore, these compounds at 10 and 15 mg/kg exhibited activity comparable to that of standard drug, donepezil. The compounds also exhibited significant acetylcholinesterase inhibitory activity.
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Isolated bioactive coumarins from C. pluricaulis ameliorated scopolamine induced amnesia in mice.
“Additionally, isolated bioactive coumarins from C. pluricaulis ameliorated scopolamine induced amnesia in mice [244].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [244]
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- Authors
- Malik, J., Karan, M., & Vasisht, K.
- Affiliations
- Panjab University (IN)
- Corresponding author
- Vasisht, Karan
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2015-04
- Volume
- 30
- Issue
- 5
- Pages
- 578-582
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2044170171
- Cited by
- 41
- References
- 15
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 4
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- Convolvulus pluricaulis, coumarins, scopoletin, scopolin, scopolamine-induced amnesia, memory enhancement, acetylcholinesterase inhibition, donepezil, medicinal plants
- MeSH terms
- Amnesia, Animals, Brain, Cholinesterase Inhibitors, Coumarins, Dose-Response Relationship, Drug, Glucosides, Medicine, Ayurvedic, Memory, Motor Activity, Scopolamine, Scopoletin, Muscarinic Antagonists, Maze Learning, Convolvulaceae, Mice
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