Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies
Abstract
C. pluricaulis Choisy (C. pluricaulis), a perennial herb aka C. microphyllus Sieb. and C. Prostratus Forsk. is being used as a traditional folk medicine for a variety of ailments. In this article, we collected information about C. pluricaulis through electronic search using PubMed, SciFinder, Google Scholar, and Web of Science as well as network pharmacology is done. This comprehensive review sheds light on the plant profile, phytochemistry, neuropharmacological, and toxicological data of C. pluricaulis. The crude herb and its metabolites have exhibited a wide range of in vitro and in vivo neuropharmacological effects, including memory enhancement, anxiolytic, tranquilizing, anti-depressant, anti-stress, neurodegenerative, anti-inflammatory, anti-oxidant, analgesic, sedative, anti-convulsant, and Alzheimer's disease-reversing effects. Network pharmacology results indicate that compounds from C. pluricaulis interact with various proteins, neuro synapses, signaling pathways, and serotonergic synapse which plays a crucial role in neurotransmission, Alzheimer's disease, long-term depression, addictions to alcohol, cognitive disorders, psychological conditions, and increasing serotonin concentration in synapses.
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Shankhapushpi exhibits neuroprotective effects including anti-Alzheimer's effects.
“Shankhapushpi exhibits a wide range of neuroprotective effects, including mental stimulant, anxiolytic, tranquilizing, immunomodulatory, anti-depressant, neurodegenerative, anti-convulsant, anti-inflammatory, antioxidant, and anti-AD effects [138].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [138]
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Sleep Disorder and its Treatment: From Nature to Laboratory
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Ayurveda intervention in Huntington\'s chorea: a case report
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Exploration of diacerein as a neuroprotective adjuvant to Adenium obesum: An in-vivo study
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Diagnosis of neuromuscular disorder
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Pharmacological Approaches and Herbal Interventions for Alzheimer's Disease
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A CRITICAL APPRAISAL OF AUTISM SPECTRUM DISORDER IN TERMS OF AYURVEDA
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Gul, S., Rahman, A., Kausar, F., Iqbal, A., Gul, H., Jan, M. S., Abdelbacki, A. M. M., Jan, R., & Kim, K. (2025) · Research Square · doi:10.21203/rs.3.rs-6223687/v1 · Cited by 1 · see citing works
Current update on management strategies for neurological and psychological disorders
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Phytotherapeutics for Alzheimer’s Disease
Kılıç, F. M. (2024) · doi:10.69860/nobel.9786053359241.7
A Comprehensive Review of Medicinal Herbs Improving Gut-Brain Health
Ramanathan, A., Rani, K. R. V., Bhupathyraaj, M., Sridhar, S. B., Shareef, J., & Thomas, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-7557-0_36
Singla, R. K., Sharma, R., & Shen, B. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156236
Self-citationAllopathic, herbal and physiotherapeutic agents: As a pyramid to tackle Parkinson’s disease
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Exploring the role of plants as neuroprotectant and its mode of action
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Therapeutic potential of Indian medicinal plants: a recent progress
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Ayurvedic management of post-herpetic neuralgia following Herpes Zoster Maxillaris: A case report
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Natural Products and Phytochemicals in Alzheimer’s Management
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Unani pharmacotherapy in the management of Parkinson's disease: A therapeutic approach
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- Authors
- Sharma, R., Singla, R. K., Banerjee, S., Sinha, B., Shen, B., & Sharma, R.
- Affiliations
- Institute of Medical Sciences (IN)
- Sichuan University (CN)
- Jadavpur University (IN)
- Corresponding author
- Shen, Bairong
- Sharma, Rohit
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 140
- Pages
- 104795
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W4286637534
- Cited by
- 81
- References
- 83
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 20 · 2023: 26 · 2022: 4
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Banaras Hindu University
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Convolvulus pluricaulis, Shankhpushpi, neuropharmacology, neurological disorders, Alzheimer's disease, memory enhancement, anxiolytic effects, antidepressant effects, neurodegeneration, anti-inflammatory activity, antioxidant activity, anticonvulsant activity, analgesic activity, serotonergic synapse, neurotransmission, phytochemistry, plant toxins, traditional medicine, network pharmacology
- MeSH terms
- Alzheimer Disease, Humans, Plant Extracts, Ethnopharmacology, Plant Preparations, Convolvulus
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