Cited by 81Medicinal Plants and NeuroprotectionMedicinal Plant Extracts EffectsPhytochemicals and Medicinal Plants

Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies

Sharma, Ruchi, Singla, Rajeev K., Banerjee, Subhadip, Sinha, Baivab, Shen, Bairong, Sharma, Rohit·2022·Neuroscience & Biobehavioral Reviews

Abstract

C. pluricaulis Choisy (C. pluricaulis), a perennial herb aka C. microphyllus Sieb. and C. Prostratus Forsk. is being used as a traditional folk medicine for a variety of ailments. In this article, we collected information about C. pluricaulis through electronic search using PubMed, SciFinder, Google Scholar, and Web of Science as well as network pharmacology is done. This comprehensive review sheds light on the plant profile, phytochemistry, neuropharmacological, and toxicological data of C. pluricaulis. The crude herb and its metabolites have exhibited a wide range of in vitro and in vivo neuropharmacological effects, including memory enhancement, anxiolytic, tranquilizing, anti-depressant, anti-stress, neurodegenerative, anti-inflammatory, anti-oxidant, analgesic, sedative, anti-convulsant, and Alzheimer's disease-reversing effects. Network pharmacology results indicate that compounds from C. pluricaulis interact with various proteins, neuro synapses, signaling pathways, and serotonergic synapse which plays a crucial role in neurotransmission, Alzheimer's disease, long-term depression, addictions to alcohol, cognitive disorders, psychological conditions, and increasing serotonin concentration in synapses.

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Crossref · 10.1016/j.neubiorev.2022.104795

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82 of 82 references verified0 citation errors · 0 not checkable

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Authors
Sharma, R., Singla, R. K., Banerjee, S., Sinha, B., Shen, B., & Sharma, R.
Affiliations
  • Institute of Medical Sciences (IN)
  • Sichuan University (CN)
  • Jadavpur University (IN)
Corresponding author
  • Shen, Bairong
  • Sharma, Rohit
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2022-09
Volume
140
Pages
104795
ISSN
0149-7634 (ISSN-L)
OpenAlex
W4286637534
Cited by
81
References
83
Citations by year
2026: 12 · 2025: 19 · 2024: 20 · 2023: 26 · 2022: 4
FWCI
4.00
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Banaras Hindu University
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Convolvulus pluricaulis, Shankhpushpi, neuropharmacology, neurological disorders, Alzheimer's disease, memory enhancement, anxiolytic effects, antidepressant effects, neurodegeneration, anti-inflammatory activity, antioxidant activity, anticonvulsant activity, analgesic activity, serotonergic synapse, neurotransmission, phytochemistry, plant toxins, traditional medicine, network pharmacology
MeSH terms
Alzheimer Disease, Humans, Plant Extracts, Ethnopharmacology, Plant Preparations, Convolvulus

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