Anxiolytic activity of Evolvulus alsinoides and Convulvulus pluricaulis in rodents
Open accessAbstract
Shankhpushpi is a popular medicinal plant in the Ayurvedic system of medicine for treating mental disorders. Convulvulus pluricaulis Choisy. (Convulvulaceae) and Evolvulus alsinoides Linn. (Convulvulaceae) are used as Shankhpushpi by Ayurvedic practitioners. Ethanol extract of the aerial parts of both these drugs was evaluated for central nervous system (CNS) activity. The ethanol extract was fractionated into ethyl acetate and aqueous fractions and was tested in experimental models employing rats and mice. Elevated plus maze test, open field exploratory behavior and rotarod performance experiments were undertaken to observe influence on CNS. The extracts were also studied for their in vitro antioxidant potential to correlate their anxiolytic activity. In the elevated plus maze, ethyl acetate fractions of both the drugs at 100 mg/kg per oral showed an anxiolytic effect as evidenced by increase in the time spent in open arms and the number of open arm entries, compared to the control group. The open field exploratory behavior was also increased on administration of the ethyl acetate fractions (100 mg/kg p.o.) of both the drugs. The ethyl acetate fractions at doses of 200 mg/kg p.o. significantly reduced the neuromuscular coordination indicative of the muscle relaxant activity at a higher dose in both the drugs. The aqueous fractions of both the drugs were devoid of the above pharmacological actions at similar doses. Diazepam (1 mg/kg i.p.) was used as a standard in all the animal models studied. The present study provides scientific support for the anxiolytic and antioxidant activities of extracts of Evolvulus alsinoides and Convulvulus pluricaulis and substantiates the traditional claims for the usage of these drugs in stress-induced disorders.
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Nahata et al. reported learning and memory enhancing property of ethanolic extract and ethyl acetate and aqueous fractions of E. alsinoides in rats.
“Nahata et al. [190] reported learning and memory enhancing property of its ethanolic extract and ethyl acetate and aqueous fractions in rats.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [190]
C. pluricaulis possesses antioxidant and hypolipidemic effects, which may be partially responsible for improvement in cognitive function.
“C. pluricaulis also possesses antioxidant and hypolipidemic effects, which may be partially responsible for improvement in cognitive function [190,241].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [190]
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- Authors
- Nahata, A., Patil, U. K., & Dixit, V. K.
- Affiliations
- Dr. Hari Singh Gour University (IN)
- Corresponding author
- Dixit, V.K.
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2009-05
- Volume
- 47
- Issue
- 5
- Pages
- 444-451
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2067926341
- Cited by
- 57
- References
- 26
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 3
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Evolvulus alsinoides, Shankhpushpi, anxiolytic effects, antioxidant activity, ethyl acetate fraction, central nervous system activity, exploratory behavior, rotarod performance, muscle relaxant activity, Ayurvedic medicinal plants, ethanol extract
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