Evaluation of anticoagulant activity of two algal polysaccharides
Open accessAbstract
Marine algae are important sources of phycocolloids like agar, carrageenans and alginates used in industrial applications. Algal polysaccharides have emerged as an important class of bioactive products showing interesting properties. The aim of our study was to evaluate the potential uses as anticoagulant drugs of algal sulphate polysaccharides extracted from Ulva fasciata (Chlorophyta) and Agardhiella subulata (Rhodophyta) collected in Ganzirri Lake (Cape Peloro Lagoon, north-eastern Sicily, Italy). Toxicity of algal extracts through trypan blue test and anticoagulant action measured by activated partial thromboplastin time (APTT), prothrombin time (PT) test has been evaluated. Algal extracts showed to prolong the PT and APTT during the coagulation cascade and to avoid the blood coagulation of samples. Furthermore, the algal extracts lack toxic effects towards cellular metabolism and their productions are relatively at low cost. This permits to consider the algae as the biological source of the future.
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Polysaccharide-rich extracts from green algae Ulva fasciata and red algae Agardhiella subulata prolong thromboplastin time and prothrombin time, avoiding blood coagulation.
“For example, in a study carried out by [79], they tested the effect of some polysaccharides rich extracts obtained from green algae Ulva fasciata and red algae Agardhiella subulata in the thromboplastin time and prothrombin time, resulting that both algal extracts showed that prolong those mentioned times during the coagulation cascade, avoiding blood coagulation.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [79]
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- Authors
- Faggio, C., Pagano, M., Dottore, A., Genovese, G., & Morabito, M.
- Affiliations
- University of Messina (IT)
- Analisi Cliniche Dottore S.RE & C., Messina, Italy
- Corresponding author
- Pagano, M.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2015-09-11
- Volume
- 30
- Issue
- 17
- Pages
- 1934-1937
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2279858157
- Cited by
- 76
- References
- 11
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 1
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (cc-by)
- Funders
- Agro Bio and Fishing Ecocompatible Technological District (MIUR) under Grant PON “INNOVAQUA- Technological Innovation for the improvement of productivity and competitiveness of Sicilian aquaculture” (PON02_00451_3362185)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- algal polysaccharides, anticoagulant activity, Ulva fasciata, Agardhiella subulata, marine algae, coagulation, activated partial thromboplastin time, prothrombin time, toxicity, bioactive natural products
- MeSH terms
- Chlorophyta, Rhodophyta, Anticoagulants, Blood Coagulation, Humans, Partial Thromboplastin Time, Polysaccharides, Prothrombin Time
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