Biological activities of sulfated polysaccharides from tropical seaweeds
Abstract
Sulfated polysaccharides from 11 species of tropical marine algae (one edible specie of Rhodophyta, six species of Phaeophyta and four species of Chlorophyta) collected from Natal city coast (Northeast of Brazil) were evaluated for their anticoagulant, antioxidant and antiproliverative in vitro activities. In the activated partial thromboplastin time (APTT) test, which evaluates the intrinsic coagulation pathway, seven seaweeds presented anticoagulant activity. Dictyota cervicornis showed the highest activity, prolonging the coagulation time to double the baseline value in the APTT with only 0.01 mg/100 microl of plasma, 1.4-fold lesser than Clexane, a low molecular weight heparin. In the protrombin time (PT) test, which evaluates the extrinsic coagulation pathway, only Caulerpa cupresoides showed anticoagulant activity. All species collected showed antioxidant activities. This screening emphasized the great antioxidant potential (total capacity antioxidant, power reducing and ferrous chelating) of four species: C. sertularioide; Dictyota cervicornis; Sargassum filipendula and Dictyopteris delicatula. After 72 h incubation, HeLa cell proliferation was inhibited (p<0.05) between 33.0 and 67.5% by S. filipendula; 31.4 and 65.7% by D. delicatula; 36.3 and 58.4% by Caulerpa prolifera and 40.2 and 61.0% by Dictyota menstrualis at 0.01-2mg/mL algal polysaccharides. The antiproliferative efficacy of these algal polysaccharides were positively correlated with the sulfate content (r=0.934). Several polysaccharides demonstrated promising antioxidant, antiproliferative an/or anticoagulant potential and have been selected for further studies on bioguided fractionation, isolation and characterization of pure polysaccharides from these species as well as in vivo experiments are needed and are already in progress.
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HeLa cell proliferation was inhibited between 36.3% and 58.4% after 72 h incubation with the polysaccharide isolated from Caulerpa prolifera.
“HeLa cell proliferation was inhibited between 36.3% and 58.4% after 72 h incubation with the polysaccharide isolated from Caulerpa prolifera [107].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [107]
Promising antioxidant and antiproliferative activities were found in sulfated polysaccharides isolated from several tropical species of green algae.
“Promising antioxidant and antiproliferative activities were recently found in the sulfated polysaccharides isolated from several tropical species of green algae.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [107]
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- Authors
- Costa, L. S., Fidelis, G. P., Cordeiro, S. L., Oliveira, R. M., Sabry, D. A., Câmara, R. B. G., Nobre, L. T. D. B., Costa, M. S. S. P., Almeida-Lima, J., Farias, E. H. C., Leite, E. L., & Rocha, H. A. O.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Corresponding author
- Rocha, H.A.O.
- ORCID
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 64
- Issue
- 1
- Pages
- 21-28
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2010001103
- Cited by
- 659
- References
- 52
- Citations by year
- 2026: 24 · 2025: 41 · 2024: 40 · 2023: 43 · 2022: 47 · 2021: 44 · 2020: 53 · 2019: 41 · 2018: 37 · 2017: 40 · 2016: 39 · 2015: 37 · 2014: 45 · 2013: 38 · 2012: 34
- FWCI
- 45.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Rio Grande do Norte
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- sulfated polysaccharides, tropical seaweeds, marine algae, anticoagulant activity, antioxidant activity, antiproliferative activity, Sargassum filipendula, Caulerpa prolifera, Dictyota menstrualis, sulfate content, heparin-like activity, coagulation pathway, Natal coast
- MeSH terms
- Phaeophyceae, Chlorophyta, Rhodophyta, Anticoagulants, Antioxidants, HeLa Cells, Humans, Partial Thromboplastin Time, Polysaccharides, Prothrombin Time, Enoxaparin, Cell Proliferation
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