Chemical constituents of Silene montbretiana
Abstract
A new steroidal glycoside, 3- O-β-d-glucopyranosyl-3β,25-dihydroxy-5β-cholest-7-en-6-one 25- O-β-d-glucopyranoside (1), together with six known steroidal derivatives (2-7), one cerebroside (8) and one flavonoid (9) were isolated from Silene montbretiana Boiss (Caryophyllaceae), a perennial herb growing mainly in the Middle and East Anatolia, Azerbaijan, Iran, and Turkey. Their structures were established by the extensive use of 1D and 2D NMR experiments along with ESI-MS analyses. The cytotoxicity against the cancer A549 (human alveolar basal carcinoma) and Hela (human epitheloid cervix carcinoma) cell lines has been evaluated. None of the tested compounds, in a range of concentrations between 12.5 and 100 μM, caused a significant reduction of the cell number.
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Compound 119 showed no significant cytotoxic activity against A549 and HeLa cells.
“Evaluated cytotoxic activity against two cancer cell lines of A549 (human lung adenocarcinoma) and HeLa cells (human epitheloidcervix carcinoma) by using the MTT assay and no significant activity have been observed.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [96]
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- Authors
- Kılınç, H., Masullo, M., Bottone, A., Karayıldırım, T., Alankuş, Ö., & Piacente, S.
- Affiliations
- Dokuz Eylül University (TR)
- University of Salerno (IT)
- Ege University (TR)
- Faculty of Science, Department of Chemistry, Ege University
- Corresponding author
- Masullo, Milena
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2018-03-21
- Volume
- 33
- Issue
- 3
- Pages
- 335-339
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2792018180
- Cited by
- 14
- References
- 23
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ege Üniversitesi (2012 FEN 047)
- TUBITAK (114Z226, 2214/A)
- International Doctoral Research Fellowship Programme (1059B141400283)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Physical Sciences › Materials Science › Biomaterials › Phytochemistry and Bioactive Compounds
- Keywords
- Caryophyllaceae, steroid glycosides, steroid derivatives, cerebrosides, flavonoids, cytotoxicity, A549 cells, HeLa cells, structure elucidation
- MeSH terms
- Flavonoids, Glycosides, HeLa Cells, Humans, Iran, Steroids, Turkey, Molecular Structure, Silene, Cell Line, Tumor, Cell Proliferation
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