Phytoecdysteroids of Silene guntensis and their in vitro cytotoxic and antioxidant activity
Open accessAbstract
Phytoecdysteroids from aerial parts of Silene guntensis B. Fedtsch were investigated and three phytoecdysteroids were isolated: 2,3-diacetate-22-benzoate-20-hydroxyecdysone (1), 2-deoxy-20-hydroxyecdysone (2), and 20-hydroxyecdysone (3). Their chemical structures were elucidated by DEPT, COSY, 1H and 13C NMR spectroscopy. The isolated compounds 1-3 and crude extracts were evaluated for their antiproliferative and antioxidant activities. They exhibited substantial inhibition of cell growth against human cervix adenocarcinoma (HeLa), hepatocellular carcinoma (HepG-2), and breast adenocarcinoma (MCF-7) cells. The chloroform extract showed potent cytotoxic effects [IC50 values (26.58 +/- 1.88) microg/mL, (20.99 +/- 1.64) microg/mL, and (18.89 +/- 2.36) microg/mL, respectively]. The new compound 1 was mildly cytotoxic compared to extracts [(127.97 +/- 11.34), (106.76 +/- 7.81), and (203.10 +/- 19.56) microg/mL, respectively]. Water and n-butanol extracts exhibited good antioxidant activities [IC50 values of (68.90 +/- 6.45) microg/mL and (69.12 +/- 5.85) microg/mL, respectively].
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Compound 120 showed moderate cytotoxic, antiproliferative, and antioxidant activities.
“Evaluated cytotoxicity, antiproliferative activities in HeLa, HepG-2, and MCF-7 cell linesand antioxidant activities and showed moderate activities.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [97]
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- Authors
- Mamadalieva, N. Z., El-Readi, M. Z., Janibekov, A. A., Tahrani, A., & Wink, M.
- Affiliations
- Yunusov Institute of the Chemistry of Plant Substances (UZ)
- Heidelberg University (DE)
- Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany
- Venue
- Zeitschrift für Naturforschung C
- Publisher
- Walter de Gruyter GmbH
- Published
- 2011-06-01
- Volume
- 66
- Issue
- 5-6
- Pages
- 215-224
- ISSN
- 0341-0471 (ISSN-L)
- 1865-7125
- 0939-5075
- OpenAlex
- W2102686157
- Cited by
- 24
- References
- 18
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2014: 4 · 2012: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Zeitschrift für Naturforschung C (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Deutscher Akademischer Austauschdienst
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- phytoecdysteroids, 20-hydroxyecdysone, structure elucidation, cytotoxicity, antioxidant activity, antiproliferative activity, HeLa cells, HepG2 cells, MCF-7 cells, plant extracts
- MeSH terms
- Antineoplastic Agents, Phytogenic, Antioxidants, Chromatography, Liquid, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Inhibitory Concentration 50, Ecdysteroids, Silene, Cell Line, Tumor
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