Toward the Study of Trans-Disease Processes: A Novel Approach With Special Reference to the Study of Co-morbidity
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The objective of this article was to propose a novel approach, referred to as the study of trans-disease processes (TDPs), to the neuroscientific study of disease processes in general and to co-morbid diseases in particular. The features of this approach are outlined; one potential TDP-delay discounting, which may help account for the co-morbidity of cigarette smoking and schizophrenia-is explored; and the concept of TDPs is contrasted with the concept of endophenotypes. TDPs have the potential for a variety of positive impacts on science.
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Bickel and Mueller suggested that excessive discounting represents a trans-disease process.
“Similarly, Bickel and Mueller [69] suggested that excessive discounting represents a trans-disease process”
From The behavioral economics and neuroeconomics of reinforcer pathologies: implications for etiology and treatment of addiction (2011) · cites this paper as [69]
The notion of reinforcer pathologies provides a means to organize and illustrate commonalities across addictions that may demonstrate the importance of trans-disease processes.
“The notion of reinforcer pathologies provides a means to organize and illustrate commonalities across addictions that may demonstrate the importance of trans-disease processes [69].”
From The behavioral economics and neuroeconomics of reinforcer pathologies: implications for etiology and treatment of addiction (2011) · cites this paper as [69]
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Effects of immediate‐reinforcement training on delay discounting behavior in rats
Fox, A. E. (2021) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.727 · Cited by 4 · see citing works
A Cup Today or a Pot Later: On the Discounting of Delayed Caffeinated Beverages
Jarmolowicz, D. P., Lemley, S. M., Cruse, D., & Sofis, M. J. (2015) · Journal of Agricultural & Food Industrial Organization · doi:10.1515/jafio-2015-0021 · Cited by 4 · see citing works
Berardi, V., Phillips, C. B., McEntee, M. L., Stecher, C. D., Todd, M. W., & Adams, M. A. (2024) · Annals of Behavioral Medicine · doi:10.1093/abm/kaae009 · Cited by 3 · see citing works
Bilevicius, E., Single, A. N., Baumgartner, C., Bui, V. T., Kempe, T., Schaub, M. P., Stewart, S. H., MacKillop, J. M., Hodgins, D. C., Wardell, J. D., et al. (2020) · Trials · doi:10.1186/s13063-020-04867-1 · Cited by 3 · see citing works
Rasmussen, E. B., Příhodová, T., Příhodová, K., & Lawyer, S. R. (2021) · European Journal of Behavior Analysis · doi:10.1080/15021149.2021.1946370 · Cited by 3 · see citing works
Delay discounting in emotional disorders: A three-level meta-analysis
Li, Q., Zhang, X., & Hu, Z. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120515 · Cited by 2 · see citing works
The Archetype of Intellectual Function: Problems of Description and Research
Arpentieva, M. R., Badalov, A. A., Калинин, С. С., Brovkina, S. N., Sorokin, A. A., Kassymova, G. K., & Menshikov, P. V. (2021) · Journal of Technology and Humanities · doi:10.53797/jthkkss.v2i1.2.2021 · Cited by 2 · see citing works
Thrailkill, E. A., DeSarno, M., & Higgins, S. T. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108093 · Cited by 2 · see citing works
Relationships between Driver Errors and Delay Discounting in a Simulated Driving Task
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Neural Influences in Contingency Management for Adolescent Substance Use
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Exercise recovers weight gain, but not increased impulsive choice, caused by a high-fat diet
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Differences in Sexual Delay Discounting Among In-Treatment Adults with Opioid Use Disorder
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Genome-wide association study of delay discounting in Heterogenous Stock ratsPreprint
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Delay of Reinforcement: Current Status and Future Directions
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Investigation of the reward value of exercise using discounting paradigm
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Behavioral economic modeling of the effects of symptom, severity, and cost on seeking medical care
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Delay Discounting and the Cost of Waiting
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Delay Discounting and the Cost of Waiting
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Validation of the Sexual Discounting Task for Use in Adolescents
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Practical applications of discounting
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The Pathogenesis of Dual Disorders: Neurobiological Perspectives
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- Authors
- Bickel, W. K., & Mueller, E. T.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- ORCID
- Bickel, Warren K.
- Venue
- Journal of Dual Diagnosis
- Publisher
- Informa UK Limited
- Published
- 2009-05-04
- Volume
- 5
- Issue
- 2
- Pages
- 131-138
- ISSN
- 1550-4263 (ISSN-L)
- 1550-4271
- PMC
- PMC2826844
- OpenAlex
- W2038620870
- Cited by
- 105
- References
- 28
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 10 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 12 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 29.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dual Diagnosis (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA022386, R01DA024080, R37DA006526, T32DA022981)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- comorbidities, delay discounting, cigarette smoking, schizophrenia, endophenotypes, dual diagnosis, psychiatric comorbidity
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