The neural basis of conceptual–emotional integration and its role in major depressive disorder
Open accessAbstract
The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge when people with MDD appraise their social actions, contributing to their tendency to grossly overgeneralize self-blame (e.g., "I am unlikable rather than critical"). To test this hypothesis, we used a neuropsychological test measuring social conceptual differentiation and its relationship with emotional biases in a remitted MDD and a control group. During fMRI, guilt- and indignation-evoking sentences were presented. As predicted, conceptual overgeneralization was associated with increased emotional intensity when appraising social actions. Interdependence of conceptual overgeneralization and negative emotional biases was stronger in MDD (reproducible in the subgroup without medication) and was associated with overgeneralized self-blame. This high conceptual-emotional interdependence was associated with functional disconnection between the right superior anterior temporal lobe (ATL) and right dorsolateral prefrontal cortex (PFC) as well as a septal region across groups when experiencing guilt (SPM8). Strong coupling of conceptual information (ATL) with information about the context of actions and emotions (frontal-subcortical regions) is thus associated with appraisal being less dependent on conceptual overgeneralization, thereby protecting against excessive self-blame.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The default mode has been related to rumination, and the right dorsolateral prefrontal cortex has been related to regulation and conceptual-emotional information integration.
“Whilst the default mode has been related to rumination, the right dlPFC has been extensively related to regulation47 and conceptual-emotional information integration48.”
From The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse (2020) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678 · see citing works
Learned helplessness in humans: Critique and reformulation.
Abramson, L. Y., Seligman, M. E., & Teasdale, J. D. (1978) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.87.1.49 · Cited by 7,121 · see citing works
Cognitive Therapy of Depression
HOLLON, S. D., & BECK, A. T. (1979) · Cognitive-Behavioral Interventions · doi:10.1016/b978-0-12-404480-7.50012-5 · Cited by 4,685 · see citing works
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Lecrubier, Y., Sheehan, D., Weiller, E., Amorim, P., Bonora, I., Sheehan, K. H., Janavs, J., & Dunbar, G. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)83296-8 · Cited by 3,513 · see citing works
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · see citing works
Where do you know what you know? The representation of semantic knowledge in the human brain
Patterson, K., Nestor, P. J., & Rogers, T. T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2277 · Cited by 2,706 · see citing works
The Neural Bases of Cognitive Conflict and Control in Moral Judgment
Greene, J. D., Nystrom, L. E., Engell, A. D., Darley, J. M., & Cohen, J. D. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.027 · Cited by 2,620 · see citing works
Exploratory Social Network Analysis with Pajek
de Nooy, W., Mrvar, A., & Batagelj, V. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108565691 · Cited by 2,089 · see citing works
Autobiographical memory specificity and emotional disorder.
Williams, J. M. G., Barnhofer, T., Crane, C., Herman, D., Raes, F., Watkins, E., & Dalgleish, T. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.122 · Cited by 1,688 · cited 2× · see citing works
“Other studies have employed experimental probes of autobiographical memory (Williams et al., 2007), personality traits attributed to oneself (Dalgleish, Hill, Golden, Morant, & Dunn, 2011; Dozois & Dobson, 2001; Goldston, Gara, & Woolfolk, 1992), or visuospatial perception (Kingsland & Greene, 1984).”
BackgroundNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · cited 2× · see citing works
“This sheds new light on the evidence that dysfunction of the dorsolateral PFC contributes to symptoms of major depression (Price & Drevets, 2010; Siegle, Thompson, Carter, Steinhauer, & Thase, 2007) and that its lesion was associated with higher rates of depression in patients with penetrating head…”
BackgroundThinking and Depression: I. Idiosyncratic Content and Cognitive Distortions
BECK, A. T. (1963) · Archives of General Psychiatry · doi:10.1001/archpsyc.1963.01720160014002 · Cited by 1,308 · see citing works
The Human Central Nervous System
Nieuwenhuys, R., Voogd, J., & van Huijzen, C. (2008) · doi:10.1007/978-3-540-34686-9 · Cited by 1,262 · see citing works
Exploratory Social Network Analysis with Pajek
de Nooy, W., Mrvar, A., & Batagelj, V. (2005) · doi:10.1017/cbo9780511806452 · Cited by 1,244 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
The neural basis of human moral cognition
Moll, J., Zahn, R., de Oliveira-Souza, R., Krueger, F., & Grafman, J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1768 · Cited by 930 · see citing works
Self-citationHuman fronto–mesolimbic networks guide decisions about charitable donation
Moll, J., Krueger, F., Zahn, R., Pardini, M., de Oliveira-Souza, R., & Grafman, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604475103 · Cited by 900 · see citing works
Self-citationSiegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857 · see citing works
The Levels of Emotional Awareness Scale: A Cognitive-Developmental Measure of Emotion
Lane, R. D., Quinlan, D. M., SCHWARTZ, G. E. R., Walker, P. A., & Zeitlin, S. B. (1990) · Journal of Personality Assessment · doi:10.1080/00223891.1990.9674052 · Cited by 797 · see citing works
Applications of Information Theory to Psychology
Garner, W. R. (1959) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-195911000-00013 · Cited by 769 · see citing works
Human prefrontal cortex: processing and representational perspectives
Wood, J. N., & Grafman, J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1033 · Cited by 721 · see citing works
Self-citationLimbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710 · see citing works
Depression-related cognitions: Antecedent or consequence?
Lewinsohn, P. M., Steinmetz, J. L., Larson, D. W., & Franklin, J. C. (1981) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.90.3.213 · Cited by 673 · see citing works
Brief Screening for Family Psychiatric History: The Family History Screen
Weissman, M. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.675 · Cited by 604 · see citing works
Social concepts are represented in the superior anterior temporal cortex
Zahn, R., Moll, J., Krüeger, F., Huey, E. D., Garrido, G. J., & Grafman, J. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607061104 · Cited by 513 · see citing works
Self-citationCoherent concepts are computed in the anterior temporal lobes
Ralph, M. A. L., Sage, K., Jones, R. W., & Mayberry, E. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907307107 · Cited by 485 · see citing works
Krüeger, F., McCabe, K., Moll, J., Kriegeskorte, N., Zahn, R., Strenziok, M., Heinecke, A., & Grafman, J. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710103104 · Cited by 395 · see citing works
Self-citationDrevets, W. C., Öngür, D., & Price, J. L. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000370 · Cited by 352 · see citing works
The Neural Basis of Human Social Values: Evidence from Functional MRI
Zahn, R., Moll, J., Paiva, M., Garrido, G., Krueger, F., Huey, E. D., & Grafman, J. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn080 · Cited by 328 · see citing works
Self-citationWiech, K., Kalisch, R., Weiskopf, N., Pleger, B., Stephan, K. E., & Dolan, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2568-06.2006 · Cited by 323 · see citing works
Conceptual Knowledge Is Underpinned by the Temporal Pole Bilaterally: Convergent Evidence from rTMS
Lambon Ralph, M. A., Pobric, G., & Jefferies, E. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn131 · Cited by 313 · see citing works
Moral judgments, emotions and the utilitarian brain
Moll, J., & de Oliveira‐Souza, R. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.001 · Cited by 309 · see citing works
Self-citationAttributional style and the generality of learned helplessness.
Alloy, L. B., Peterson, C., Abramson, L. Y., & Seligman, M. E. (1984) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.46.3.681 · Cited by 275 · see citing works
Generalization and Differentiation in Semantic Memory
Ralph, M. A. L., & Patterson, K. E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.006 · Cited by 273 · see citing works
Social cognition and the anterior temporal lobes
Ross, L. A., & Olson, I. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.012 · Cited by 261 · see citing works
Psychological differentiation: Current status.
Witkin, H. A., Goodenough, D. R., & Oltman, P. K. (1979) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.37.7.1127 · Cited by 252 · see citing works
The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
Simmons, W. K., Reddish, M., Bellgowan, P. S. F., & Martin, A. D. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp149 · Cited by 244 · see citing works
Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression
Koenigs, M., Huey, E. D., Calamia, M., Raymont, V., Tranel, D., & Grafman, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2324-08.2008 · Cited by 243 · see citing works
Self-citationPredictive, interactive multiple memory systems
Henson, R. N., & Gagnepain, P. (2010) · Hippocampus · doi:10.1002/hipo.20857 · Cited by 226 · see citing works
The Neural Basis of Moral Cognition
Moll, J., de Oliveira‐Souza, R., & Zahn, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.005 · Cited by 216 · see citing works
Self-citationAnterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
Warren, J. E., Crinion, J., Ralph, M. A. L., & Wise, R. J. S. (2009) · Brain · doi:10.1093/brain/awp270 · Cited by 188 · see citing works
Eslinger, P. J., Moore, P., Anderson, C., & Grossman, M. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.1.74 · Cited by 184 · see citing works
Zahn, R., Moll, J., Iyengar, V., Huey, E. D., Tierney, M., Krüeger, F., & Grafman, J. H. (2009) · Brain · doi:10.1093/brain/awn343 · Cited by 183 · see citing works
Self-citationRalph, M. A. L., Ehsan, S., Baker, G. A., & Rogers, T. T. (2012) · Brain · doi:10.1093/brain/awr325 · Cited by 169 · see citing works
Interpersonal guilt: The development of a new measure
O’Connor, L. E., Berry, J. W., Weiss, J., Bush, M., & Sampson, H. (1997) · Journal of Clinical Psychology · doi:10.1002/(sici)1097-4679(199701)53:1 · Cited by 168 · see citing works
The year in cognitive neuroscience
Kingstone, A. F., & Miller, M. B. (2008) · Cited by 164 · see citing works
Wilson, M. R. (2023) · Routledge eBooks · doi:10.4324/9781003286929 · Cited by 157 · see citing works
Sensory and semantic category subdivisions within the anterior temporal lobes
Skipper‐Kallal, L. M., Ross, L. A., & Olson, I. R. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.07.033 · Cited by 135 · see citing works
Deontological and altruistic guilt: evidence for distinct neurobiological substrates
Basile, B., Mancini, F., Macaluso, E., Caltagirone, C., Frackowiak, R. S. J., & Bozzali, M. (2011) · Human Brain Mapping · doi:10.1002/hbm.21009 · Cited by 133 · see citing works
Moll, J., Zahn, R., de Oliveira-Souza, R., Bramati, I., Krueger, F., Tura, B., Cavanagh, A., & Grafman, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.026 · Cited by 131 · see citing works
Self-citationBhagwagar, Z., & Cowen, P. J. (2008) · Psychological Medicine · doi:10.1017/s0033291707001250 · Cited by 124 · see citing works
The Human Central Nervous System
Nieuwenhuys, R., Voogd, J., & van Huijzen, C. (1978) · Springer eBooks · doi:10.1007/978-3-642-96477-0 · Cited by 123 · see citing works
Property norms for typical and atypical items from 17 categories: A description and discussion
Ashcraft, M. H. (1978) · Memory & Cognition · doi:10.3758/bf03197450 · Cited by 120 · see citing works
Ghatavi, K., Nicolson, R., MacDonald, C., Osher, S., & Levitt, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00335-4 · Cited by 104 · see citing works
Green, S., Lambon Ralph, M. A., Moll, J., Deakin, J. F. W., & Zahn, R. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.135 · Cited by 98 · see citing works
Self-citationDozois, D. J. A., & Dobson, K. S. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.69.6.914 · Cited by 95 · see citing works
Scars in depression: is a conceptual shift necessary to solve the puzzle?
Wichers, M., Geschwind, N., van Os, J., & Peeters, F. P. M. L. (2009) · Psychological Medicine · doi:10.1017/s0033291709990420 · Cited by 91 · see citing works
Subgenual cingulate activity reflects individual differences in empathic concern
Zahn, R., de Oliveira‐Souza, R., Bramati, I. E., Garrido, G. J., & Moll, J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.090 · Cited by 73 · see citing works
Self-citationNeural systems for guilt from actions affecting self versus others
Morey, R. A., McCarthy, G., Selgrade, E. S., Seth, S., Nasser, J. D., & LaBar, K. S. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.069 · Cited by 66 · see citing works
Psychological differentiation as a factor in conflict resolution.
Oltman, P. K., & al, E. (1975) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.32.4.730 · Cited by 61 · see citing works
Green, S., Moll, J., Deakin, J. F. W., Hulleman, J., & Zahn, R. (2012) · Psychopathology · doi:10.1159/000338632 · Cited by 54 · see citing works
Self-citationThe structure of past and future lives in depression.
Dalgleish, T., Hill, E., Golden, A.-M. J., Morant, N. J., & Dunn, B. D. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0020797 · Cited by 53 · see citing works
Green, S., Ralph, M. A. L., Moll, J., Stamatakis, E. A., Grafman, J. H., & Zahn, R. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.038 · Cited by 47 · see citing works
Self-citationResponse to Greene: Moral sentiments and reason: friends or foes?
Moll, J., & de Oliveira‐Souza, R. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.011 · Cited by 26 · see citing works
Self-citationGoldston, R. B., Gara, M. A., & Woolfolk, R. L. (1992) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199211000-00005 · Cited by 23 · see citing works
Psychological differentiation and clinical depression
Kingsland, R. C., & Greene, L. R. (1984) · Cognitive Therapy and Research · doi:10.1007/bf01173258 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- First MB Spitzer RL Gibbon M Williams JBW 2002 Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P) New York Biometrics Research, New York State Psychiatric Institute
- Hall CS Lindzey G 1978 Lewin’s field theory Theories of personality 3 383 437 New York John Wiley & Sons
Cited by
Sorted by citations
Neuroplasticity Underlying the Comorbidity of Pain and Depression
Doan, L., Manders, T. R., & Wang, J. (2015) · Neural Plasticity · doi:10.1155/2015/504691 · Cited by 284 · see citing works
The role of self-blame and worthlessness in the psychopathology of major depressive disorder
Zahn, R., Lythe, K. E., Gethin, J. A., Green, S., Deakin, J. F. W., Young, A. H., & Moll, J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.001 · Cited by 207 · see citing works
Self-citationFeelings of shame, embarrassment and guilt and their neural correlates: A systematic review
Bastin, C., Harrison, B. J., Davey, C. G., Moll, J., & Whittle, S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.019 · Cited by 165 · see citing works
Self-citationLythe, K. E., Moll, J., Gethin, J. A., Workman, C. I., Green, S., Lambon Ralph, M. A., Deakin, J. F. W., & Zahn, R. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1813 · Cited by 91 · see citing works
Self-citationBland, A., Roiser, J., Mehta, M., Schei, T., Boland, H., Campbell-Meiklejohn, D., Emsley, R., Munafo, M., Penton-Voak, I., Seara-Cardoso, A., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00025 · Cited by 106 · see citing works
der Gucht, K. V., Dejonckheere, E., Erbaş, Y., Takano, K., Vandemoortele, M., Maex, E., Raes, F., & Kuppens, P. (2018) · Emotion · doi:10.1037/emo0000406 · Cited by 102 · see citing works
Du, L., Liu, H., Du, W., Chao, F., Zhang, L., Wang, K., Huang, C., Gao, Y., & Tang, Y. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0005-6 · Cited by 94 · see citing works
Machine learning algorithm accurately detects fMRI signature of vulnerability to major depression
Sato, J. R., Moll, J., Green, S., Deakin, J. F. W., Thomaz, C. E., & Zahn, R. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.07.001 · Cited by 68 · see citing works
Self-citationBerwian, I. M., Wenzel, J. G., Kuehn, L., Schnuerer, I., Kasper, L., Veer, I. M., Seifritz, E., Stephan, K. E., Walter, H., & Huys, Q. J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-79170-9 · Cited by 29 · see citing works
Moser, D. A., Suardi, F., Rossignol, A. S., Vital, M., Manini, A., Serpa, S. R., & Schechter, D. S. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.09.005 · Cited by 31 · see citing works
Blame-rebalance fMRI neurofeedback in major depressive disorder: A randomised proof-of-concept trial
Zahn, R., Weingartner, J. H., Basílio, R., Bado, P., Mattos, P., Sato, J. R., de Oliveira‐Souza, R., Fontenelle, L. F., Young, A. H., & Moll, J. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101992 · Cited by 29 · see citing works
Self-citationEmotional caricatures in frontotemporal dementia
Clark, C. N., & Warren, J. D. (2015) · Cortex · doi:10.1016/j.cortex.2015.07.026 · Cited by 20 · see citing works
Subgenual activation and the finger of blame: individual differences and depression vulnerability
Lythe, K. E., Gethin, J. A., Workman, C. I., Ralph, M. A. L., Deakin, J. F. W., Moll, J., & Zahn, R. (2020) · Psychological Medicine · doi:10.1017/s0033291720003372 · Cited by 22 · see citing works
Self-citationRemote virtual reality assessment elucidates self-blame-related action tendencies in depression
Duan, S., Valmaggia, L., Fennema, D., Moll, J., & Zahn, R. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.02.031 · Cited by 16 · see citing works
Self-citationBulteau, S., Sauvaget, A., Vanier, A., Vanelle, J., Poulet, E., Brunelin, J., & Sebille, V. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00420 · Cited by 16 · see citing works
Lü, Y., Li, J., & Liu, Y. (2019) · Journal of Advanced Nursing · doi:10.1111/jan.14111 · Cited by 15 · see citing works
Early life stress explains reduced positive memory biases in remitted depression
Gethin, J. A., Lythe, K. E., Workman, C. I., Mayes, A. R., Moll, J., & Zahn, R. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.06.011 · Cited by 14 · see citing works
Self-citationMarín-Marín, L., Lagranja, J. R., Ávila, C., & Costumero, V. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230929 · Cited by 5 · see citing works
Examining brain structural-functional coupling in major depressive disorder across episode status
Chen, Z., Li, X., Wang, R., Xie, Y., Yin, Q., Zhong, M., Liu, T., Liu, Z., Zhou, X., Yang, J., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120406 · Cited by 3 · see citing works
(n.d.) · Progress in Neuro-Psychopharmacology and Biological Psychiatry / PsyPost · doi:10.1016/j.pnpbp.2026.111679
The role of moral cognition and emotions in remitted major depressive disorder
Workman, C. I. (2016) · Research Explorer (The University of Manchester)
Shame proneness is associated with individual differences in temporal pole white matter structure
Miyauchi, C. M., Takeuchi, H., Taki, Y., Nakagawa, S., Hanawa, S., Sekiguchi, A., Nouchi, R., Sassa, Y., & Kawashima, R. (2022) · Social Neuroscience · doi:10.1080/17470919.2022.2039287
Self-blame-selective social conceptual overgeneralization and vulnerability to depressionPreprint
Fennema, D., Lawrence, A. J., Spilling, C. A., Moll, J., Ralph, M. A. L., & Zahn, R. (2025) · medRxiv · doi:10.1101/2025.05.06.25327075
Self-citationSelf-blame-selective social conceptual overgeneralisation and vulnerability to depression
Fennema, D., Lawrence, A. J., Spilling, C. A., Moll, J., Ralph, M. A. L., & Zahn, R. (2026) · Cortex · doi:10.1016/j.cortex.2026.02.018
Self-citation
- Authors
- Green, S., Lambon Ralph, M. A., Moll, J., Zakrzewski, J., Deakin, J. F. W., Grafman, J., & Zahn, R.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Neuroscience and Aphasia Research Unit, School of Psychological Sciences, The University of Manchester & Manchester Academic Health Sciences Centre
- D’Or Institute for Research and Education (BR)
- Northwestern University (US)
- Corresponding author
- Zahn, Roland
- Venue
- Social Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2013-07-04
- Volume
- 8
- Issue
- 5
- Pages
- 417-433
- ISSN
- 1747-0919 (ISSN-L)
- 1747-0927
- PMC
- PMC3783899
- OpenAlex
- W2098111967
- Cited by
- 24
- References
- 70
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 5
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (ZIANS002792)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, self-blame, guilt, indignation, emotional bias, dorsolateral prefrontal cortex, functional disconnection, septal area, remitted depression
- MeSH terms
- Brain, Brain Mapping, Concept Formation, Major Depressive Disorder, Depressive Disorder, Major, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Psychometrics, Social Behavior, Statistics, Nonparametric
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
