Cited by 23Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesNanoparticle-Based Drug Delivery

CPX-351 in acute myeloid leukemia: can a new formulation maximize the efficacy of old compounds?

Brunetti, Claudia, Anelli, Luisa, Zagaria, Antonella, Specchia, Giorgina, Albano, Francesco·2017·Expert Review of Hematology

Abstract

INTRODUCTION: The management of Acute Myeloid Leukemia (AML) (with the exception of acute promyelocytic leukemia) has remained largely unchanged over the past 40 years. In particular, patients defined as high-risk, according to the 2017 European Leukemia Net recommendations, represent a subgroup with poor response to current therapies that are frequently associated with high-grade toxicity and potentially fatal complications. Areas covered: Preliminary results from an ongoing phase III clinical trial suggest that CPX-351 could represent an interesting treatment option in both induction and 'bridge-to-transplant' settings. In particular, 60- to 75-year-old patients with secondary AML, when treated with CPX-351, exhibit superior overall survival (HR = 0.69; P = 0.005; median OS 9.56 vs. 5.95 months), event free survival (HR = 0.74; P = 0.021), and composite response rate (47.7% vs. 33.3%; P = 0.016) as compared to standard '7 + 3' therapy. Herein, we detail the main pharmacological features of CPX-351 and review updated results of clinical trials investigating its employment in AML. Expert commentary: Novel liposome-based drugs display a high therapeutic index and represent a promising alternative to unencapsulated drugs, especially when high-risk features complicate the use of standard treatments. Further efforts in both understanding AML biology and improving nanodrug design are needed.

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Crossref · 10.1080/17474086.2017.1369400

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74 of 74 references verified0 citation errors · 0 not checkable

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  • CPX-351 is approved by the US FDA for the treatment of adults with newly diagnosed acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) and therapy-related AML (t-AML).

    “This liposomal nanoparticles are approved from US FDA for the for the treatment of adults with newly diagnosed acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) and therapy-related AML (t-AML).347”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [347]

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Authors
Brunetti, C., Anelli, L., Zagaria, A., Specchia, G., & Albano, F.
Affiliations
University of Bari Aldo Moro (IT)
Corresponding author
Albano, Francesco
Venue
Expert Review of Hematology
Published
2017-08-24
Volume
10
Issue
10
Pages
853-862
ISSN
  • 1747-4086 (ISSN-L)
  • 1747-4094
OpenAlex
W2747821992
Cited by
23
References
73
Citations by year
2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 8 · 2018: 5
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Hematology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
CPX-351, acute myeloid leukemia, high-risk AML, liposomal doxorubicin, secondary acute myeloid leukemia, 7+3 induction chemotherapy, overall survival, event-free survival
MeSH terms
Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Drug Compounding, Drug Evaluation, Preclinical, Humans, Liposomes, Leukemia, Myeloid, Acute, Treatment Outcome, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Nanomedicine, Drug Discovery

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