Medications for substance use disorders
Open accessAbstract
In this article, the authors briefly review the pharmacotherapeutic agents that are currently available for the treatment of substance use disorders. Nicotine replacement therapies are most effective for tobacco cessation. Naltrexone, acamprosate, and disulfiram are effective for reducing alcohol use. The most effective pharmacotherapies for opiate use disorders are agonist therapies, including methadone and buprenorphine. The authors also examine recent advances in medication development for other substance use disorders such as stimulant addiction. The role of medication adherence and behavioral treatments and the integration of behavioral and pharmacotherapeutic interventions are also discussed.
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Pharmacologic interventions aim to alter the reward system by reducing stimuli that positively reinforce drinking or introducing aversive stimuli that counter-condition alcohol use.
“Pharmacologic interventions aim to alter the reward system by reducing stimuli that positively reinforce drinking or introducing aversive stimuli that counter‐condition alcohol use (Douaihy 2013).”
From Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries (2023) · cites this paper as Douaihy 2013
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Cites
Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321 · see citing works
Motivational interviewing: preparing people for change.
Miller, W. R., & Rollnick, S. (2002) · Cited by 7,002 · see citing works
Cochrane Database of Systematic Reviews
(2008) · Springer eBooks · doi:10.1007/978-1-4020-5614-7_436 · Cited by 4,552 · see citing works
Drug Dependence, a Chronic Medical Illness
McLellan, A. T., Lewis, D. C., O'Brien, C. P., & Kleber, H. D. (2000) · JAMA · doi:10.1001/jama.284.13.1689 · Cited by 2,622 · see citing works
(2005) · JAMA · doi:10.1001/jama.294.19.2423-c · Cited by 2,325 · see citing works
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence
Mattick, R. P., Breen, C. L., Kimber, J., & Davoli, M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002207.pub4 · Cited by 2,312 · see citing works
Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930 · see citing works
Cochrane Database of Systematic Reviews
Lyons, R. (2006) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.208 · Cited by 1,907 · see citing works
Alcoholism: Clinical and Experimental Research
(2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/(issn)1530-0277 · Cited by 1,830 · see citing works
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
Mattick, R. P., Breen, C., Kimber, J., & Davoli, M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002209.pub2 · Cited by 1,654 · see citing works
The Cochrane Database of Systematic Reviews
Handoll, H. H., Howe, T. E., & Madhok, R. (2002) · Physiotherapy · doi:10.1016/s0031-9406(05)60709-2 · Cited by 1,497 · see citing works
A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation
Hurt, R. D., Sachs, D. P. L., Glover, E. D., Offord, K. P., Johnston, J. A., Dale, L. C., Khayrallah, M. A., Schroeder, D. R., Glover, P. N., Sullivan, C. R., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710233371703 · Cited by 1,253 · see citing works
Self-citationA Randomized Trial of Methods to Help Clinicians Learn Motivational Interviewing.
Miller, W. R., Yahne, C. E., Moyers, T. B., Martinez, J., & Pirritano, M. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.6.1050 · Cited by 1,075 · see citing works
Individual behavioural counselling for smoking cessation
Lancaster, T., & Stead, L. F. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001292.pub2 · Cited by 1,015 · see citing works
Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050069n · Cited by 930 · see citing works
The Effects of Psychosocial Services in Substance Abuse Treatment
McLellan, A. T. (1993) · JAMA · doi:10.1001/jama.1993.03500150065028 · Cited by 827 · see citing works
Oral topiramate for treatment of alcohol dependence: A randomised controlled trial
Johnson, B. A., Ait-Daoud, N., Bowden, C. L., DiClemente, C. C., Roache, J. D., Lawson, K., Javors, M. A., & Ma, J. Z. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13370-3 · Cited by 743 · see citing works
Antidepressants for smoking cessation
Hughes, J., Stead, L., & Lancaster, T. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000031 · Cited by 683 · see citing works
Efficacy and Tolerability of Long-Acting Injectable Naltrexone for Alcohol Dependence
Garbutt, J. C., Kranzler, H. R., O’Malley, S. S., Gastfriend, D. R., Pettinati, H. M., Silverman, B. L., Loewy, J. W., Ehrich, E. W., & for the Vivitrex Study Group (2005) · JAMA · doi:10.1001/jama.293.13.1617 · Cited by 632 · see citing works
Naltrexone in the Treatment of Alcohol Dependence
Krystal, J. H., Cramer, J. A., Krol, W. F., Kirk, G. F., & Rosenheck, R. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011127 · Cited by 618 · see citing works
Lancaster, T. (2000) · BMJ · doi:10.1136/bmj.321.7257.355 · Cited by 563 · see citing works
Management of Drug and Alcohol Withdrawal
Kosten, T. R., & O'Connor, P. G. (2003) · New England Journal of Medicine · doi:10.1056/nejmra020617 · Cited by 563 · see citing works
Johnson, B. A. (2007) · JAMA · doi:10.1001/jama.298.14.1641 · Cited by 542 · see citing works
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.256.11.1449 · Cited by 541 · see citing works
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
Mattick, R. P., Breen, C. L., Kimber, J., Davoli, M., & Breen, R. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002209 · Cited by 536 · see citing works
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence
Mattick, R. P., Kimber, J., Breen, C., & Davoli, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002207.pub3 · Cited by 501 · see citing works
Addictions: A Comprehensive Guidebook
McCrady, B. S., & Epstein, E. E. (2013) · Cited by 488 · see citing works
Effectiveness of smoking cessation therapies: a systematic review and meta-analysis
Wu, P., Wilson, K., Dimoulas, P., & Mills, E. J. (2006) · BMC Public Health · doi:10.1186/1471-2458-6-300 · Cited by 484 · see citing works
Oral naltrexone maintenance treatment for opioid dependence
Minozzi, S., Amato, L., Vecchi, S., Davoli, M., Kirchmayer, U., & Verster, A. D. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001333.pub4 · Cited by 432 · see citing works
Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients
Carroll, K. M., Fenton, L. R., Ball, S. A., Nich, C., Frankforter, T. L., Shi, J. M., & Rounsaville, B. J. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.264 · Cited by 410 · see citing works
Anticraving Medications for Relapse Prevention: A Possible New Class of Psychoactive Medications
O’Brien, C. P. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1423 · Cited by 405 · see citing works
A Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine Dependence
Dackis, C. A., Kampman, K. M., Lynch, K. G., Pettinati, H. M., & O'Brien, C. P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300600 · Cited by 391 · see citing works
Gonzalez, J. P., & Brogden, R. N. (1988) · Drugs · doi:10.2165/00003495-198835030-00002 · Cited by 315 · see citing works
Treatment of substance abusing patients with comorbid psychiatric disorders
Kelly, T. M., Daley, D. C., & Douaihy, A. B. (2011) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.09.010 · Cited by 283 · see citing works
Self-citationClonidine for smoking cessation
Gourlay, S. G., Stead, L. F., & Benowitz, N. L. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000058.pub2 · Cited by 248 · see citing works
The effects of psychosocial services in substance abuse treatment
McLellan, A. T. (1993) · JAMA · doi:10.1001/jama.269.15.1953 · Cited by 248 · see citing works
Methadone versus buprenorphine in pregnant addicts: a double‐blind, double‐dummy comparison study
Fischer, G., Ortner, R., Rohrmeister, K., Jagsch, R., Baewert, A., Langer, M., & Aschauer, H. N. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01321.x · Cited by 235 · see citing works
Pharmacotherapy for Nicotine Dependence
Henningfield, J. E., Fant, R. V., Buchhalter, A. R., & Stitzer, M. L. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.5.281 · Cited by 232 · see citing works
MASON, B., GOODMAN, A., Chabac, S., & Lehert, P. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.002 · Cited by 212 · see citing works
Safety and immunogenicity of a nicotine conjugate vaccine in current smokers
HATSUKAMI, D., RENNARD, S., JORENBY, D., FIORE, M., KOOPMEINERS, J., DEVOS, A., HORWITH, G., & PENTEL, P. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.08.007 · Cited by 194 · see citing works
A double-blind, placebo-controlled trial of modafinil for cocaine dependence
Dackis, C. A., Kampman, K. M., Lynch, K. G., Plebani, J. G., Pettinati, H. M., Sparkman, T., & O'Brien, C. P. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.12.014 · Cited by 187 · see citing works
Bobo, J. K., McIlvain, H. E., Lando, H. A., Walker, R. D., & Leed‐Kelly, A. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.9368779.x · Cited by 183 · see citing works
Does disulfiram have a role in alcoholism treatment today?
FULLER, R. K., & GORDIS, E. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00597.x · Cited by 182 · see citing works
West, R., Hájek, P., Foulds, J., Nilsson, F. O. L., May, S., & Meadows, A. T. (2000) · Psychopharmacology · doi:10.1007/s002130000382 · Cited by 181 · see citing works
The Community Reinforcement Approach
Meyers, R. J., Smith, J. E., & Lash, D. N. (2002) · Springer eBooks · doi:10.1007/0-306-47939-7_14 · Cited by 180 · see citing works
Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis
Farré, M., Mas, A., Torrens, M., Moreno, V. R., & Camı́, J. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(01)00171-5 · Cited by 180 · see citing works
Current pharmacological treatments for nicotine dependence
George, T. P., & O’Malley, S. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.11.003 · Cited by 179 · see citing works
Individual behavioural counselling for smoking cessation
Lancaster, T., & Stead, L. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001292 · Cited by 178 · see citing works
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
Fuller, R. K., Branchey, L., Brightwell, D. R., Derman, R., Emrick, C. D., Iber, F. L., James, K. E., Lacoursiere, R. B., Lee, K. K., & Lowenstam, I. (1986) · PubMed · Cited by 166 · see citing works
The efficacy of disulfiram: a review of outcome studies
HUGHES, J. C., & COOK, C. C. H. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb03370.x · Cited by 162 · see citing works
Antidepressant treatment of co-occurring depression and alcohol dependence
Pettinati, H. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.016 · Cited by 141 · see citing works
Immunotherapy for the treatment of drug abuse
Kosten, T., & Owens, S. M. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.009 · Cited by 135 · see citing works
Combination Nicotine Replacement Therapy for Smoking Cessation
Sweeney, C. T., Fant, R. V., Fagerström, K. O., McGovern, J. F., & Henningfield, J. E. (2001) · CNS Drugs · doi:10.2165/00023210-200115060-00004 · Cited by 128 · see citing works
Update on Pharmacologic Options for Smoking Cessation Treatment
Nides, M. A. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.01.016 · Cited by 128 · see citing works
Pettinati, H. M., Volpicelli, J. R., Pierce, J. D., & O’Brien, C. P. (2000) · Journal of Addictive Diseases · doi:10.1300/j069v19n01_06 · Cited by 122 · see citing works
The state of pharmacotherapy for the treatment of alcohol dependence.
Garbutt, J. C. (2009) · PubMed · Cited by 119 · see citing works
Contingency management: what it is and why psychiatrists should want to use it
Petry, N. M. (2011) · The Psychiatrist · doi:10.1192/pb.bp.110.031831 · Cited by 117 · see citing works
Novel pharmacotherapeutic treatments for cocaine addiction
Shorter, D. I., & Kosten, T. R. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-119 · Cited by 113 · see citing works
Sustained-Release Naltrexone For Opioid Dependence
Lobmaier, P. P. K., Kornør, H., Kunøe, N., & Bjørndal, A. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006140.pub2 · Cited by 109 · see citing works
Project Match Treatment Participation and Outcome by Self‐Reported Ethnicity
Tonigan, J. S. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000080673.83739.f3 · Cited by 109 · see citing works
Oral naltrexone maintenance treatment for opioid dependence
Minozzi, S., Amato, L., Vecchi, S., Davoli, M., Kirchmayer, U., & Verster, A. D. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001333.pub2 · Cited by 106 · see citing works
Nortriptyline for smoking cessation: A review
Hughes, J. R., Stead, L. F., & Lancaster, T. (2005) · Nicotine & Tobacco Research · doi:10.1080/14622200500185298 · Cited by 103 · see citing works
Naltrexone in the treatment of alcohol dependence
Mangado, E. O. (1994) · Alcohol · doi:10.1016/0741-8329(94)90014-0 · Cited by 100 · see citing works
Donny, E. C., WALSH, S. L., Bigelow, G. E., Eissenberg, T., & Stitzer, M. L. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1027-0 · Cited by 93 · see citing works
Clinical Efficacy of Bupropion in the Management of Smoking Cessation
Jorenby, D. E. (2002) · Drugs · doi:10.2165/00003495-200262002-00003 · Cited by 89 · see citing works
Pharmacologic approaches to the management of alcoholism.
Anton, R. F. (2001) · PubMed · Cited by 79 · see citing works
Combating opiate dependence: a comparison among the available pharmacological options
Gonzalez, G. M., Oliveto, A. H., & Kosten, T. R. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.4.713 · Cited by 77 · see citing works
Mason, B. J. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.009 · Cited by 75 · see citing works
Adverse effects and tolerability of medications for the treatment of tobacco use and dependence
Hays, J. T., & Ebbert, J. O. (2010) · Drugs · doi:10.2165/11538190-000000000-00000 · Cited by 74 · see citing works
Intramuscular extended‐release naltrexone: current evidence
Gastfriend, D. R. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05900.x · Cited by 71 · see citing works
Pharmacological Treatment of Cannabis Dependence
Weinstein, A. M., & Gorelick, D. A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796150846 · Cited by 70 · see citing works
Holt, L. J., Litt, M. D., & Cooney, N. L. (2011) · Psychology of Addictive Behaviors · doi:10.1037/a0026039 · Cited by 70 · see citing works
Rychtarik, R. G., Connors, G. J., Dermen, K. H., & Stasiewicz, P. R. (2000) · Journal of Studies on Alcohol · doi:10.15288/jsa.2000.61.134 · Cited by 69 · see citing works
Acamprosate in Alcohol Dependence: Implications of a Unique Mechanism of Action
Littleton, J. M. (2007) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318156c26f · Cited by 68 · see citing works
The Clinical Use of Disulfiram (Antabuse®): A Review
Banys, P. (1988) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1988.10472495 · Cited by 63 · see citing works
Alcohol abuse and alcoholism: an overview.
Volpicelli, J. R. (2001) · PubMed · Cited by 58 · see citing works
Treatment of Tobacco Dependence
Batra, A. (2011) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2011.0555 · Cited by 56 · see citing works
Combination Pharmacotherapy for Stopping Smoking: What Advantages Does it Offer?
Ebbert, J. O., Hays, J. T., & Hurt, R. D. (2010) · Drugs · doi:10.2165/11536100-000000000-00000 · Cited by 53 · see citing works
Strat, Y. L., Ramoz, N., & Gorwood, P. A. P. M. (2010) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp094 · Cited by 53 · see citing works
Preclinical and clinical pharmacology of alcohol dependence
Tambour, S., & Quertemont, É. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00459.x · Cited by 53 · see citing works
Naltrexone plus group therapy for the treatment of opiate-abusing health-care professionals
Roth, A., Hogan, I., & Farren, C. K. (1997) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(96)00164-x · Cited by 51 · see citing works
Smoking cessation: How compelling is the evidence? A review
Tønnesen, P. (2009) · Health Policy · doi:10.1016/s0168-8510(09)70004-1 · Cited by 46 · see citing works
Extended-release naltrexone for treatment of alcohol dependence in primary care
Lee, J. D., Grossman, E., DiRocco, D., Truncali, A., Hanley, K., Stevens, D. L., Rotrosen, J., & Gourevitch, M. N. (2010) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2010.03.005 · Cited by 45 · see citing works
The Community Reinforcement Approach.
Meyers, R. J., Smith, J. E., & Lash, D. N. (2003) · PubMed · Cited by 42 · see citing works
Hepatic Extraction of Long- and Short-Acting Narcotics in the Isolated Perfused Rabbit Liver
Kreek, M. J., Oratz, M., & Rothschild, M. A. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)93770-8 · Cited by 40 · see citing works
NONPHARMACOLOGIC APPROACHES TO SUBSTANCE ABUSE TREATMENT
Carroll, K. M., & Schottenfeld, R. S. (1997) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70556-3 · Cited by 38 · see citing works
Topiramate for the treatment of alcohol dependence: initiating abstinence
Swift, R. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13378-8 · Cited by 29 · see citing works
Intensive Intervention for Alcohol-Dependent Smokers in Early Recovery: A Randomized Trial
Carmody, T., Delucchi, K., Duncan, C., Banys, P., Simon, J., Solkowitz, S., Huggins, J., Lee, S. K., & Hall, S. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.09.026 · Cited by 27 · see citing works
The Role of Psychosocial Treatments in Pharmacotherapy for Alcoholism
McCaul, M. E., & Petry, N. M. (2003) · American Journal on Addictions · doi:10.1111/j.1521-0391.2003.tb00495.x · Cited by 24 · see citing works
Pharmacotherapy of Alcohol Use Disorders
Buonopane, A., & Petrakis, I. L. (2005) · Substance Use & Misuse · doi:10.1080/10826080500294890 · Cited by 24 · see citing works
Heffner, J. L., Tran, G. Q., Johnson, C. S., Barrett, S. W., Blom, T. J., Thompson, R. D., & Anthenelli, R. M. (2010) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2010.71.61 · Cited by 22 · see citing works
van Meijgaard, J., & Fielding, J. (2012) · Preventing Chronic Disease · doi:10.5888/pcd9.110295 · Cited by 19 · see citing works
Beliefs About AA and the Use of Medications
Tonigan, J. S., & Kelly, J. F. (2004) · Alcoholism Treatment Quarterly · doi:10.1300/j020v22n02_06 · Cited by 17 · see citing works
Varenicline for smoking cessation: Is it a heartbreaker?
Hays, J. T. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.110804 · Cited by 13 · see citing works
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- Batki SL Kauffman JF Marion I Parrino MW Woody GE 2005 Medication assisted treatment for opioid addiction in opioid treatment programs 43 TIP series Rockville, MD Center for Substance Abuse Treatment 22514849
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Wang, S.-C. (2018) · Cell Transplantation · doi:10.1177/0963689718811060 · Cited by 188 · see citing works
Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review
Wang, S.-C., Chen, Y., Lee, C.-H., & Cheng, C.-M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174294 · Cited by 150 · see citing works
Marsch, L. A., Carroll, K. M., & Kiluk, B. D. (2013) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2013.08.010 · Cited by 105 · see citing works
Internet interventions for adult illicit substance users: a meta‐analysis
Boumparis, N., Karyotaki, E., Schaub, M. P., Cuijpers, P., & Riper, H. (2017) · Addiction · doi:10.1111/add.13819 · Cited by 104 · see citing works
“Pharmacological interventions are not yet available for amphetamine and cocaine users [8].”
BackgroundBruns, N., Tressler, E. H., Vendruscolo, L. F., Leggio, L., & Farokhnia, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107312 · Cited by 89 · see citing works
Addiction, cognitive decline and therapy: Seeking ways to escape a vicious cycle
Perry, C. J., & Lawrence, A. J. (2017) · Genes, Brain and Behavior · doi:10.1111/gbb.12325 · Cited by 60 · see citing works
Houston, R. J., & Schlienz, N. J. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.09.006 · Cited by 53 · see citing works
Chen, F., Wang, X., Jang, S.-K., Quach, B. C., Weissenkampen, J. D., Khunsriraksakul, C., Yang, L., Sauteraud, R., Albert, C. M., Palmer, N. D., et al. (2023) · Nature Genetics · doi:10.1038/s41588-022-01282-x · Cited by 50 · see citing works
Self-citationBridging the gap between the neurocognitive lab and the addiction clinic
Franken, I. H. A., & van de Wetering, B. J. M. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.11.034 · Cited by 42 · see citing works
Dickler, M., Lenglos, C., Renauld, E., Ferland, F., Edden, R. A. E., Leblond, J., & Fecteau, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.002 · Cited by 35 · see citing works
Nanoparticle delivery systems for substance use disorder
Kasina, V., Mownn, R. J., Bahal, R., & Sartor, G. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01311-7 · Cited by 37 · see citing works
Machine-learning repurposing of DrugBank compounds for opioid use disorder
Feng, H., Jiang, J., & Wei, G. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106921 · Cited by 35 · see citing works
van Wel, J. H. P., Kinyua, J., van Nuijs, A. L. N., Salvatore, S., Bramness, J. G., Covaci, A., & Hal, G. F. V. (2016) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2016.04.003 · Cited by 34 · see citing works
Sarkar, S., Tom, A., & Mandal, P. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1908359 · Cited by 32 · see citing works
Meade, E., Hehir, S., Rowan, N. J., & Garvey, M. (2022) · Journal of Fungi · doi:10.3390/jof8030290 · Cited by 24 · see citing works
Vassar, M. B., Pollard, J., Rorah, D., Jellison, S., Harter, Z. J., & Brasseux, S. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107824 · Cited by 20 · see citing works
Barriers to retention in substance use treatment: Validation of a new, theory-based scale
Zemore, S. E., Ware, O. D., Gilbert, P. A., & Pinedo, M. (2021) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2021.108422 · Cited by 21 · see citing works
Clerke, J. A., Congiu, M., & Mameli, M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108617 · Cited by 20 · see citing works
Tijani, A. O., Garg, J., Frempong, D., Verana, G., Kaur, J., Joga, R., Sabanis, C. D., Kumar, S., Kumar, N., & Puri, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.034 · Cited by 17 · see citing works
Fluyau, D., Revadigar, N., & Pierre, C. G. (2020) · American Journal on Addictions · doi:10.1111/ajad.13133 · Cited by 13 · see citing works
Cognitive–affective factors underlying disinhibitory disorders and legal implications
Baskin-sommers, A. R., Ruiz, S. G., Sarcos, B., & Simmons, C. (2022) · Nature Reviews Psychology · doi:10.1038/s44159-022-00020-8 · Cited by 15 · see citing works
Alizadeh, S., Mahmoudi, G. A., Solhi, H., Sadeghi-Sedeh, B., Behzadi, R., & Kazemifar, A. M. (2015) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Psychedelic Therapy: A Primer for Primary Care Clinicians—Ketamine
Evans, V. D., Arenas, A., Shinozuka, K., Tabaac, B. J., Beutler, B. D., Cherian, K. N., Fasano, C., & Muir, O. S. (2024) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001721 · Cited by 16 · see citing works
Technology-Based Interventions and Trainings to Reduce the Escalation and Impact of Alcohol Problems
Resko, S. M., Brown, S., Lister, J. J., Ondersma, S. J., Cunningham, R. M., & Walton, M. A. (2017) · Journal of Social Work Practice in the Addictions · doi:10.1080/1533256x.2017.1304948 · Cited by 13 · see citing works
Comer, S. D., Mannelli, P., Alam, D., Douaihy, A. B., Nangia, N., Akerman, S. C., Zavod, A., Silverman, B. L., & Sullivan, M. A. (2020) · American Journal on Addictions · doi:10.1111/ajad.13024 · Cited by 13 · see citing works
Self-citationFeng, H., Wang, R., Zhan, C., & Wei, G. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01053 · Cited by 12 · see citing works
Ubhayarathna, M., Langmead, C. J., Diepenhorst, N. A., & Stewart, G. D. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16233 · Cited by 12 · see citing works
Influence of Microelement Concentration on the Intensity of Alcohol Withdrawal Syndrome
Prior, P. L., Vaz, M. J., Ramos, A. C., & Galduróz, J. C. F. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu094 · Cited by 12 · see citing works
Greene, M. C., Kane, J., Alto, M., Giusto, A., Lovero, K., Stockton, M., McClendon, J., Nicholson, T., Wainberg, M. L., Johnson, R. M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013350.pub2 · Cited by 11 · see citing works
Airoldi, C., Pagnoni, F., Cena, T., Ceriotti, D., Ambrosi, D. D., Vito, M. D., & Faggiano, F. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-070820 · Cited by 11 · see citing works
Redonnet, B., Eren, F., Avenin, G., Melchior, M., & Mary‐Krause, M. (2025) · Addiction · doi:10.1111/add.16745 · Cited by 10 · see citing works
Neurocognitive Disorders in Substance Use Disorders
Ekhtiari, H., Zare-Bidoky, M., & Verdejo‐García, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-36391-8_81 · Cited by 10 · see citing works
Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse
Bardo, M. T., Horton, D. B., & Yates, J. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00007-2 · Cited by 9 · see citing works
Qeadan, F., Shimizu, S., Tingey, B., Kroth, P. J., & Markossian, T. W. (2025) · SSM - Population Health · doi:10.1016/j.ssmph.2025.101780 · Cited by 8 · see citing works
Neuroscience and addiction research: current advances and perspectives
Darcq, E., & Kieffer, B. L. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02763-5 · Cited by 8 · see citing works
Cabrera-Mendoza, B., Martínez-Magaña, J., Monroy-Jaramillo, N., Genis-Mendoza, A., Fresno, C., Fries, G., Walss-Bass, C., López-Armenta, M., García-Dolores, F., Díaz-Otañez, C., et al. (2021) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32830 · Cited by 8 · see citing works
Pharmacological treatments for co-occurring PTSD and substance use disorders: A systematic review
Swannell, M., Bradlow, R. C. J., Pham, D., Gabriel, J., Manahan, Y., & Arunogiri, S. (2024) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2024.209601 · Cited by 7 · see citing works
Jiang, W., Chen, J., Zhang, P., Zheng, N., Ma, L., Zhang, Y.-G., & Zhang, H. (2023) · Molecules · doi:10.3390/molecules28217325 · Cited by 6 · see citing works
Greene, M. C., Kane, J. C., Johnson, R. M., & Tol, W. A. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013350 · Cited by 7 · see citing works
Bustamante, P. H., Charles, A., Snider, M., & Catanzano, S. (2025) · Mental Health Clinician · doi:10.9740/mhc.2025.02.017 · Cited by 5 · see citing works
United States Schools and the Opioid Crisis: Charting New Directions
Harrod, S. B., Harrison, S. E., McQuillin, S. D., & Weist, M. D. (2024) · American Journal of Health Education · doi:10.1080/19325037.2023.2295558 · Cited by 5 · see citing works
Glasgow, L., Douglas, C. E., Sprunger, J. G., Campbell, A. N. C., Chandler, R. K., Dasgupta, A., Holloway, J., Marks, K. R., Roberts, S. M., Martinez, L. S. S., et al. (2024) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2024.111286 · Cited by 5 · see citing works
Substance-Induced Anxiety and Co-occurring Anxiety Disorders
Blaney, D., Jackson, A. K., Toy, O., Fitzgerald, A., & Piechniczek‐Buczek, J. (2019) · Current clinical psychiatry · doi:10.1007/978-3-319-23961-3_8 · Cited by 5 · see citing works
Ngai, C. K. H., Wu, C. S. T., & Suen, L. K. P. (2020) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1713423 · Cited by 5 · see citing works
Morgan, W. S., Schultz, K. V., Adiba, A., & Lohr, W. D. (2022) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2022.06.011 · Cited by 5 · see citing works
Farabee, D. J. (2017) · European Journal on Criminal Policy and Research · doi:10.1007/s10610-017-9349-y · Cited by 5 · see citing works
Stakehold ZXSY: Disorder Deficit Familial Asynchrony and Syndrome Z
(2023) · Journal of Medical Clinical Case Reports · doi:10.47485/2767-5416.1032 · Cited by 4 · see citing works
Microbiome‐derived metabolites in substance use disorders: Mechanisms and implications
Koperska, M., & Kiraly, D. D. (2025) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15416 · Cited by 4 · see citing works
(2014) · Cited by 4 · see citing works
Madde Bağımlılığı ve Farkındalık Terapisi: Tedavi Yöntemleri ve Örnek Sosyal Hizmet Uygulaması
Şen, Z. Ş., Danış, M. Z., & Kutlu, İ. (2025) · International Journal of Social Inquiry · doi:10.37093/ijsi.1650018 · Cited by 3 · see citing works
PSICOFÁRMACOS NO TRATAMENTO DA DEPENDÊNCIA QUÍMICA: UMA REVISÃO
Knevitz, M. F., & Buccini, D. F. (2018) · Revista Interdisciplinar de Estudos em Saúde · doi:10.33362/ries.v7i1.1124 · Cited by 3 · see citing works
Prescription Opioids: An Overview
Dasgupta, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820075-9.00002-8 · Cited by 3 · see citing works
Alcohol and Substance Use Disorders in Medical Rehabilitation
Skidmore, W. C., & Budd, M. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-34034-0_28 · Cited by 3 · see citing works
Sihag, M., Varma, M., Bhandari, R., & Lawrence, A. J. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-024-01492-8 · Cited by 2 · see citing works
Brown, R. E., Chan, W.-Y., & Whyte, F. (2023) · Journal of the California Dental Association · doi:10.1080/19424396.2023.2242570 · Cited by 2 · see citing works
Janero, D. R. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.951631 · Cited by 2 · see citing works
mGlu5 Signaling: A Target for Addiction Therapeutics?
Perry, C. J., Olive, M. F., & Lawrence, A. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-56170-7_1 · Cited by 2 · see citing works
The Deep Roots of Addiction: A Comparative Perspective
Karnib, N., & van Staaden, M. J. (2020) · Brain Behavior and Evolution · doi:10.1159/000514180 · Cited by 2 · see citing works
Ghosh, A., Sharma, N., Noble, D., Subodh, B. N., Basu, D., Mattoo, S. K., & Pillai, R. R. (2021) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-021-00702-z · Cited by 2 · see citing works
Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammationPreprint
Bhandari, B., Chagas, H. I. S., Naeini, S. E., Chagas, P. S., Rogers, H. M., Gouron, J., Khan, A., Maciel, L. M., Seyyedi, M., MacKinnon, N. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.20.604441 · Cited by 2 · see citing works
Robeck, I. R., & Mudra, S. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-72216-2.00009-0 · Cited by 1 · see citing works
The Nature of Substance Abuse Treatment in South Africa: A Social Work Perspective
Khosa, P., & Ndou, N. (2022) · SOUTHERN AFRICAN JOURNAL OF SOCIAL WORK AND SOCIAL DEVELOPMENT · doi:10.25159/2708-9355/10408 · Cited by 1 · see citing works
A Study on Islamic Psycho-Spiritual Therapy on Recovered Adolescent Addicts
Ismail, N. A. H., Haris, R. H., Kassim, S. K., & Mat, M. Z. A. (2022) · SYAMIL Jurnal Pendidikan Agama Islam (Journal of Islamic Education) · doi:10.21093/sy.v10i2.5653 · Cited by 1 · see citing works
Simulating the effects of medicaid expansion on the opioid epidemic in North Carolina
Berghammer, A., Adams, J. W., Khan, S. S., & Bobashev, G. (2024) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2024.100262 · Cited by 1 · see citing works
Boeshore, K. L., Lee, C., & Freed, W. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823882-0.00006-0 · Cited by 1 · see citing works
Teal, L. B., Ingram, S., Bubser, M., McClure, E. W., & Jones, C. K. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-21054-9_3 · Cited by 2 · see citing works
When ADHD and substance use disorders coexist : etiology and pharmacological treatment
Skoglund, C. B. (2015) · Figshare · Cited by 1 · see citing works
Risk factors for violent behavior in people with psychotic disorders
Lamsma, J. (2021) · doi:10.33540/496 · Cited by 1 · see citing works
Smoking Cessation Among Methadone Users In Mauritius
RN, B., & Roland, G. (2014) · IOSR Journal of Nursing and health Science · doi:10.9790/1959-03333241
Hamza, D. M. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r31v5br91
Ndou, N. (2019) · SUNScholar (Stellenbosch University)
Substances Pathological of Use and Syndrome Z: Medicine D
Furlanetto, M. L. (2023) · Journal of Integrated Health · doi:10.51219/jih/furlanetto-m-l-jr/4
Dialectical Medicine: Z Syndrome and Use of Pathological Substances, The Clinical Case
Furlanetto, M. L. (2023) · Journal of Clinical Case Studies Reviews & Reports · doi:10.47363/jccsr/2023(5)242
Başer, O., Zeng, Y., & Baser, I. E. (2023) · Research Square · doi:10.21203/rs.3.rs-3367285/v1
Herrera-Imbroda, J., Flores-López, M., Requena-Ocaña, N., Araos, P. F., García‐Marchena, N., Ropero, J., Bordallo-Aragón, A., Suárez, J., Pavón, F. J., Serrano, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914788
Driving innovation in addiction treatment: role of transcranial magnetic stimulation
Madeo, G., & Bonci, A. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-023-02734-2
Psilocybin in the Management of Substance Use Disorders: A Summary of Current Evidence
Bourji, H. E., Farhat, A., Hamdan, Z., Satodiya, R. M., Shukla, R., & Hayek, S. E. (2024) · Current Psychopharmacologye · doi:10.2174/0122115560288779240628043307
Nemati, S., & Mahmoudi, E. (2024) · فصلنامه علمی و پژوهشی اعتیادپژوهی · doi:10.61186/etiadpajohi.18.71.165
Opioid Kullanım Bozukluğu ve Farmakolojik Tedavisinde Kullanılan İlaçlar
Ertuğ, P., & Ecemiş, S. (2024) · Arşiv Kaynak Tarama Dergisi · doi:10.17827/aktd.1492043
Opioids today: From pharmacology to crisis management and emerging solutions
Shah, B. D., Gandhi, R. P., Lalwani, D. N., Bankhele, P. S., & Pathak, P. D. (2024) · World Journal of Biology Pharmacy and Health Sciences · doi:10.30574/wjbphs.2024.20.3.1030
Oyerinde, T. O., Asuku, A. O., Olajide, T. S., Afolabi, H. O., Kehinde, A., Saliu, S. B., & Arinde, E. S. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5464-3.ch011
Tran, N. (2025) · American Journal of Psychiatry Residents Journal · doi:10.1176/appi.ajp-rj.2025.200310
Raj, R., Parveen, S., Khanam, A., Bashir, K., Kashab, H., Wani, Z. A., Wani, S. M., & Rather, Y. H. (2025) · Journal of Substance Use · doi:10.1080/14659891.2025.2516523
Chladek, J. S., & Chui, M. A. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1514939
Unlocking the potential of Ayurveda and medicinal plants in deaddiction: A scientific exploration
Nath, R., Mahajon, B., & Rai, A. K. (2025) · Future Health · doi:10.25259/fh_30_2025
khaloei, H., Mobashery, A., Tavassoli, S. H., & Ameli, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5547540
Integrative Approaches to Treatment and Recovery of Substance Use Disorders (SUD)
Mostafa, S. A., Elemary, E. A., Allam, R. A., & El-Fattah, N. A. A. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-1414-4_22
Memantine treatment improves opioid-induced hyperalgesia symptoms: randomize clinical trial
Anjomshoaa, A., Zolghadriha, A., Haj-seyed-taghia, N. S., Saed, O., & Faghihzadeh, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-23068-x
Prevalence of Substance Use in Northwest Syria: A Cross-Sectional Study
Draper, I. A., Albaba, D., Mesbah, H., Taktak, H., Saadoun, N., Alhusein, M., Alissa, E., Barbour, A., Sahloul, Z., & Moukaddam, N. J. (2026) · International Journal of Public Health · doi:10.3389/ijph.2026.1608611
Psychedelics in the Future of Global Mental Healthcare
Aleksandrova, L. R., Thiessen, K. A., Chen, F. X. F., Phillips, A. G., Schütz, C. G., & Krausz, M. (2026) · Springer eBooks · doi:10.1007/978-3-319-70134-9_174-1
Jones, H. E., & Ramage, M. (2026) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2026.2756492
- Authors
- Douaihy, A. B., Kelly, T. M., & Sullivan, C.
- Affiliations
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- West Virginia University (US)
- ORCID
- Kelly, Thomas M.
- Venue
- Social Work in Public Health
- Publisher
- Informa UK Limited
- Published
- 2013-05
- Volume
- 28
- Issue
- 3-4
- Pages
- 264-278
- ISSN
- 1937-190X (ISSN-L)
- 1937-1918
- PMC
- PMC3767185
- OpenAlex
- W2081515697
- Cited by
- 93
- References
- 93
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 13 · 2023: 15 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Social Work in Public Health (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u10da020036-10)
- National Institute on Drug Abuse (U10-DA020036)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- substance use disorders, pharmacotherapy, nicotine replacement therapy, tobacco cessation, naltrexone, acamprosate, disulfiram, alcohol consumption reduction, methadone, buprenorphine, opioid substitution therapy, opioid use disorder, stimulant use disorder, medication adherence, behavior therapy, integrated treatment
- MeSH terms
- Alcohol Deterrents, Alcoholism, Analgesics, Opioid, Behavior Therapy, Buprenorphine, Disulfiram, Humans, Naltrexone, Narcotic Antagonists, Substance Withdrawal Syndrome, Tobacco Use Disorder, Smoking Cessation, Behavior, Addictive, Substance-Related Disorders, Secondary Prevention
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