The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39 + Foxp3 + T cells and T reg function
Open accessAbstract
Polysaccharide A (PSA) derived from the human commensal Bacteroides fragilis is a symbiosis factor that stimulates immunologic development within mammalian hosts. PSA rebalances skewed systemic T helper responses and promotes T regulatory cells (Tregs). However, PSA-mediated induction of Foxp3 in humans has not been reported. In mice, PSA-generated Foxp3(+) Tregs dampen Th17 activity thereby facilitating bacterial intestinal colonization while the increased presence and function of these regulatory cells may guard against pathological organ-specific inflammation in hosts. We herein demonstrate that PSA induces expression of Foxp3 along with CD39 among naïve CD4 T cells in vitro while promoting IL-10 secretion. PSA-activated dendritic cells are essential for the mediation of this regulatory response. When cultured with isolated Foxp3(+) Tregs, PSA enriched Foxp3 expression, enhanced the frequency of CD39(+)HLA-DR(+) cells, and increased suppressive function as measured by decreased TNFα expression by LPS-stimulated monocytes. Our findings are the first to demonstrate in vitro induction of human CD4(+)Foxp3(+) T cells and enhanced suppressive function of circulating Foxp3(+) Tregs by a human commensal bacterial symbiotic factor. Use of PSA for the treatment of human autoimmune diseases, in particular multiple sclerosis and inflammatory bowel disease, may represent a new paradigm in the approach to treating autoimmune disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“PSA exposure increases expression of ENTPD1 on FoxP3+ Tregs, thus suggesting a potential intersection between PSA and (microbially derived) extracellular ATP in the regulation of the immune system (Telesford et al., 2015).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Telesford et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Self-citationCD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
Francisco, L. M., Salinas, V. H., Brown, K. E., Vanguri, V. K., Freeman, G. J., Kuchroo, V. K., & Sharpe, A. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090847 · Cited by 2,072
Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., Eeckhaut, V., Ballet, V., Claes, K., Van Immerseel, F., Verbeke, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304833 · Cited by 1,904
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604
Research works printed but not linked: 3
- Ochoa-Repáraz J, 2010, Mucosal immunology, 1
- Lu Y, 2014, J Immunol Res, 1
- Ramsdell F, 2014, Nat Pub Group, 14, 343
Cited by
Sorted by citations
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells
Cervantes-Barragan, L., Chai, J. N., Tianero, M. D., Di Luccia, B., Ahern, P. P., Merriman, J., Cortez, V. S., Caparon, M. G., Donia, M. S., Gilfillan, S., et al. (2017) · Science · doi:10.1126/science.aah5825 · Cited by 896
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
“…PSA also activates toll-like receptor (TLR) 2 expressed on the surface of DCs, which triggers the release of cytokines that promote IL-10 production by T cells (Cobb et al., 2004; Dasgupta et al., 2014; Johnson et al., 2015; Mazmanian et al., 2005, 2008; Telesford et al., 2015; Wang et al., 2006).”
BackgroundLeaky Gut As a Danger Signal for Autoimmune Diseases
Mu, Q., Kirby, J. L., Reilly, C. M., & Luo, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00598 · Cited by 634
The gut microbiota influences anticancer immunosurveillance and general health
Routy, B., Gopalakrishnan, V., Daillère, R., Zitvogel, L., Wargo, J. A., & Kroemer, G. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0006-2 · Cited by 523
Dietary fiber and SCFAs in the regulation of mucosal immunity
Tan, J. K., Macia, L., & Mackay, C. R. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.11.007 · Cited by 439
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities
Zeng, Q., Li, D., He, Y., Li, Y., Yang, Z., Zhao, X., Liu, Y., Wang, Y., Sun, J., Feng, X., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49462-w · Cited by 412
Chung, W. S. F., Meijerink, M., Zeuner, B., Holck, J., Louis, P., Meyer, A. S., Wells, J. M., Flint, H. J., & Duncan, S. H. (2017) · FEMS Microbiology Ecology · doi:10.1093/femsec/fix127 · Cited by 404
The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease
Yan, J., Luo, M., Chen, Z., & He, B. (2020) · Journal of Immunology Research · doi:10.1155/2020/8813558 · Cited by 365
Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma
Chen, C., Wang, Z., Ding, Y., & Qin, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133308 · Cited by 336
Ramakrishna, C., Kujawski, M., Chu, H., Li, L., Mazmanian, S. K., & Cantin, E. M. (2019) · Nature Communications · doi:10.1038/s41467-019-09884-6 · Cited by 284
Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 263
Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk
Ma, N., Guo, P., Zhang, J., He, T., Kim, S. W., Zhang, G., & Ma, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00005 · Cited by 252
The Mechanism of Bacteroides fragilis Toxin Contributes to Colon Cancer Formation
Cheng, W. T., Kantilal, H. K., & Davamani, F. A. (2020) · Malaysian Journal of Medical Sciences · doi:10.21315/mjms2020.27.4.2 · Cited by 251
Verma, R., Lee, C., Jeun, E.-J., Yi, J., Kim, K. S., Ghosh, A., Byun, S., Lee, C.-G., Kang, H.-J., Kim, G.-C., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat6975 · Cited by 242
The microbiome and autoimmunity: a paradigm from the gut–liver axis
Li, B., Selmi, C. F., Tang, R., Gershwin, M. E., & Ma, X. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.7 · Cited by 237
Impact of gut microbiota on diabetes mellitus
Blandino, G., Inturri, R., Lazzara, F., Rosa, M. D., & Malaguarnera, L. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.04.004 · Cited by 235
Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities
Zhao, T., Wei, Y., Zhu, Y., Xie, Z., Hai, Q., Li, Z., & Qin, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007165 · Cited by 243
Microbiota in T-cell homeostasis and inflammatory diseases
Lee, N., & Kim, W. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.36 · Cited by 208
Next-generation probiotics: the upcoming biotherapeutics
Al-Fakhrany, O. M., & Elekhnawy, E. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09398-5 · Cited by 208
Laforest‐Lapointe, I., & Arrieta, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00788 · Cited by 195
Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases
Toor, D., Wasson, M. K., Goel, C., Kaushik, N. K., Kaushik, N. K., Singh, S., Karthikeyan, G., Kumar, A., & Prakash, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102432 · Cited by 188
Lamas, B., Breyner, N. M., & Houdeau, É. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00349-z · Cited by 182
Ahmed, J., Kumar, A., Parikh, K., Anwar, A., Knoll, B. M., Puccio, C. A., Chun, H. G., Fanucchi, M. P., & Lim, S. H. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1507670 · Cited by 177
Chernikova, D. A., Madan, J. C., Housman, M. L., Zain-Ul-Abideen, M., Lundgren, S., Morrison, H. G., Sogin, M. L., Williams, S. M., Moore, J. H., Karagas, M. R., et al. (2018) · Pediatric Research · doi:10.1038/s41390-018-0022-z · Cited by 168
Chu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 164
Diet, Gut Microbiota, and Vitamins D + A in Multiple Sclerosis
Riccio, P., & Rossano, R. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0581-4 · Cited by 164
Neff, C. P., Rhodes, M. E., Arnolds, K. L., Collins, C. B., Donnelly, J., Nusbacher, N. M., Jedlicka, P., Schneider, J. M., McCarter, M. D., Shaffer, M., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.09.002 · Cited by 136
Zakharzhevskaya, N. B., Vanyushkina, A., Altukhov, I. A., Shavarda, A. L., Butenko, I., Rakitina, D. V., Nikitina, A. S., Manolov, A. I., Egorova, A. N., Kulikov, E. E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05264-6 · Cited by 138
Lactobacillus maintains healthy gut mucosa by producing L-Ornithine
Qi, H., Li, Y., Yun, H., Zhang, T., Huang, Y., Jiang, Z., Yan, H., Wei, J., Liu, Y., Zhang, Z., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0424-4 · Cited by 137
Vitetta, L., Vitetta, G., & Hall, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02240 · Cited by 137
The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?
Ochoa‐Repáraz, J., & Kasper, L. H. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0191-1 · Cited by 141
Self-citationDysbiosis of gut microbiota in patients with esophageal cancer
Deng, Y., Tang, D., Hou, P., Shen, W., Li, H., Wang, T., & Liu, R. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104709 · Cited by 133
Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease
Zhang, W., Liu, X., Zhu, Y., Liu, X., Gu, Y., Dai, X., & Li, B. (2021) · European Journal of Immunology · doi:10.1002/eji.202048794 · Cited by 130
Impact of early gut microbiota on immune and metabolic development and function
Wang, M., Monaco, M. H., & Donovan, S. M. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.004 · Cited by 130
The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue
Kirby, T. O., & Ochoa‐Repáraz, J. (2018) · Medical Sciences · doi:10.3390/medsci6030069 · Cited by 114
Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis
Calvo‐Barreiro, L., Eixarch, H., Montalbán, X., & Espejo, C. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.11.019 · Cited by 95
Wang, J., Qie, J., Zhu, D., Zhang, X., Zhang, Q., Xu, Y., Wang, Y., Mi, K., Yang, P., Liu, Y., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2107288 · Cited by 94
Next‐Generation Probiotics: Microflora Intervention to Human Diseases
Zhang, H., Duan, Y., Cai, F., Cao, D., Wang, L., Qiao, Z., Hong, Q., Li, N., Zheng, Y., Su, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/5633403 · Cited by 99
Adapting Cancer Immunotherapy Models for the Real World
Klevorn, L. E., & Teague, R. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.010 · Cited by 88
The gut microbiome and microbial translocation in multiple sclerosis
Mirza, A., & Mao‐Draayer, Y. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.03.001 · Cited by 92
The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome
Trujillo-Vargas, C. M., Schaefer, L., Alam, J., Pflugfelder, S. C., Britton, R. A., & de Paiva, C. S. (2019) · The Ocular Surface · doi:10.1016/j.jtos.2019.10.006 · Cited by 87
Cui, H., Wang, N., Li, H., Bian, Y., Wen, W., Kong, X., & Wang, F. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01505-0 · Cited by 93
Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis
Chen, P., & Tang, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.803101 · Cited by 86
Molecular Insight into Gut Microbiota and Rheumatoid Arthritis
Wu, X., He, B., Liu, J., Feng, H., Ma, Y., Li, D., Guo, B., Liang, C., Dang, L., Wang, L., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030431 · Cited by 85
Shamoon, M., Martin, N. M., & O'Brien, C. L. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104344 · Cited by 73
van den Hoogen, W., Laman, J. D., & Hart, B. A. ‘. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01081 · Cited by 76
Gastrointestinal and Hepatic Disease in Rheumatoid Arthritis
Craig, E. T., & Cappelli, L. C. (2017) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2017.09.005 · Cited by 75
Emerging Frontiers in Microbiome Engineering
Inda, M. E., Broset, E., Lu, T. K., & de la Fuente‐Núñez, C. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.08.007 · Cited by 74
Microbiome of HIV-infected people
Dubourg, G., Surénaud, M., Lévy, Y., Hüe, S., & Raoult, D. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.05.015 · Cited by 68
Fu, J., Wang, Y., Tan, S., & Wang, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.575724 · Cited by 68
Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65
Laragione, T., Harris, C. L., Azizgolshani, N., Beeton, C., Bongers, G., & Gulko, P. S. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104603 · Cited by 63
Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis
Czaja, A. J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i42.9257 · Cited by 63
Ertürk-Hasdemir, D., & Kasper, D. L. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13660 · Cited by 69
Self-citationInflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Carasso, S., Zaatry, R., Hajjo, H., Kadosh-Kariti, D., Ben-Assa, N., Naddaf, R., Mandelbaum, N., Pressman, S., Chowers, Y., Gefen, T., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.02.003 · Cited by 64
Influence of the Gut Microbiome on Autoimmunity in the Central Nervous System
Colpitts, S. L., & Kasper, L. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601438 · Cited by 61
Self-citationPatient-Specific Bacteroides Genome Variants in Pouchitis
Vineis, J. H., Ringus, D. L., Morrison, H. G., Delmont, T. O., Dalal, S. R., Raffals, L. H., Antonopoulos, D. A., Rubin, D. T., Eren, A. M., Chang, E. B., et al. (2016) · mBio · doi:10.1128/mbio.01713-16 · Cited by 55
The Role of the Gut Microbiome in Cancer Immunotherapy: Current Knowledge and Future Directions
Kiousi, D. E., Kouroutzidou, A. Z., Neanidis, K., Karavanis, E., Matthaios, D., Pappa, A., & Galanis, Α. (2023) · Cancers · doi:10.3390/cancers15072101 · Cited by 62
Gut microbiota in regulatory T cell generation and function: mechanisms and health implications
Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 68
Metabolic regulation in the immune response to cancer
Wu, Q., Yu, X., Li, J., Sun, S., & Tu, Y. (2021) · 癌症：英文版 · doi:10.1002/cac2.12182 · Cited by 57
Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract – A Two-Hit Hypothesis
Zhong, G. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.12.002 · Cited by 55
Gut-derived butyrate suppresses ocular surface inflammation
Schaefer, L., Hernandez, H., Coats, R. A., Yu, Z., Pflugfelder, S. C., Britton, R. A., & de Paiva, C. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-08442-3 · Cited by 55
Stanisavljević, S., Lukić, J., Bajić, S. S., Mihajlović, S., Stojković, M. M., Miljković, D. M., & Golić, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02005 · Cited by 55
García-Vello, P., Sharma, G., Speciale, I., Molinaro, A., Im, S., & Castro, C. D. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115857 · Cited by 53
Wang, Y., Li, Y., Lin, Y., Cao, C.-Y., Chen, D., Huang, X., Li, C., Xu, H., Lai, H., Chen, H., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02413-z · Cited by 60
Environmental control of autoimmune inflammation in the central nervous system
Rothhammer, V., & Quintana, F. J. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.09.002 · Cited by 52
Gut microbiome and multiple sclerosis: New insights and perspective
Amini, M. E., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107024 · Cited by 54
Jiang, J., Chu, C., Wu, C., Wang, C., Zhang, C., Li, T., Zhai, Q., Yu, L., Tian, F., & Chen, W. (2021) · Food & Function · doi:10.1039/d0fo03203d · Cited by 52
Breaking down the gut microbiome composition in multiple sclerosis
Budhram, A., Parvathy, S., Kremenchutzky, M., & Silverman, M. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458516682105 · Cited by 51
Gut microbiota and metabolites in the pathogenesis of endocrine disease
Fenneman, A. C., Rampanelli, E., Yin, Y. S., Ames, J., Blaser, M. J., Fliers, E., & Nieuwdorp, M. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190686 · Cited by 51
The Gut Microbiota: A Novel Player in Autoimmune Hepatitis
Cheng, Z., Yang, L., & Chu, H. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.947382 · Cited by 51
Ertürk-Hasdemir, D., Ochoa‐Repáraz, J., Kasper, D. L., & Kasper, L. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662807 · Cited by 51
Self-citationThe interplay between microbiota and inflammation: lessons from peritonitis and sepsis
Lobo, L. A., Benjamim, C. F., & Oliveira, A. C. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.32 · Cited by 52
Targeting Innate-Like T Cells in Tuberculosis
Huang, S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00594 · Cited by 48
Immunomodulatory Roles of Polysaccharide Capsules in the Intestine
Hsieh, S. A., & Allen, P. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00690 · Cited by 54
Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases
Abdel-Gadir, A., Massoud, A. H., & Chatila, T. A. (2018) · F1000Research · doi:10.12688/f1000research.12650.1 · Cited by 48
Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration
Stolzer, I., Scherer, E., Süß, P., Rothhammer, V., Winner, B., Neurath, M. F., & Günther, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914925 · Cited by 49
Mestre, L., Carrillo-Salinas, F. J., Mecha, M., Feliú, A., Espejo, C., Alvarez-Cermeño, J. C., Villar, L. M., & Guaza, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01374 · Cited by 48
Gut microbiota in systemic lupus erythematosus: A fuse and a solution
Chen, Y., Lin, J., Xiao, L., Zhang, X., Zhao, L., Wang, M., & Li, L. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102867 · Cited by 48
Feeding the gut microbiome: impact on multiple sclerosis
Bronzini, M., Maglione, A., Rosso, R., Matta, M., Masuzzo, F., Rolla, S., & Clerico, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1176016 · Cited by 49
Alsharairi, N. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249580 · Cited by 46
Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity
Meng, X. L., Zhou, H., Shen, H., Lufumpa, E., Li, X., Guo, B., & Li, B. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.006 · Cited by 46
Fleck, A.-K., Schuppan, D., Wiendl, H., & Klotz, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071526 · Cited by 47
Blais, L. L., Montgomery, T. L., Amiel, E., Deming, P. B., & Krementsov, D. N. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1943289 · Cited by 45
Zhu, X., Zhang, C., Feng, S., He, R., & Zhang, S. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01304-4 · Cited by 52
Rubas, N. C., Torres, A., & Maunakea, A. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178658 · Cited by 46
Mestre, L., Carrillo-Salinas, F. J., Mecha, M., Feliú, A., & Guaza, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.037 · Cited by 43
Yadav, S. K., Ito, K., & Dhib-Jalbut, S. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914756 · Cited by 44
Targeting gut microbiota: new therapeutic opportunities in multiple sclerosis
Kujawa, D., Łaczmański, Ł., Budrewicz, S. P., Pokryszko‐Dragan, A., & Podbielska, M. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2274126 · Cited by 45
Roszyk, E., & Puszczewicz, M. (2017) · Reumatologia/Rheumatology · doi:10.5114/reum.2017.71641 · Cited by 41
Mestre, L., Carrillo-Salinas, F. J., Feliú, A., Mecha, M., Alonso, G., Espejo, C., Calvo‐Barreiro, L., Luque-Garcia, J. L., Estévez, H., Villar, L. M., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1813532 · Cited by 42
Alsharairi, N. A. (2021) · Nutrients · doi:10.3390/nu13113702 · Cited by 44
The influence of the commensal microbiota on distal tumor-promoting inflammation
Rosean, C. M. B., & Rutkowski, M. R. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.06.002 · Cited by 40
Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions
Kononova, S., Litvinova, E. A., Vakhitov, T., Skalinskaya, M. I., & Sitkin, S. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083854 · Cited by 41
Galley, J. D., Mackos, A. R., Varaljay, V. A., & Bailey, M. T. (2017) · Scientific Reports · doi:10.1038/srep45012 · Cited by 37
Alsharairi, N. A. (2022) · Nutrients · doi:10.3390/nu14194113 · Cited by 37
Cheru, L., Park, J., Saylor, C. F., Burdo, T. H., Fitch, K. V., Looby, S. E. D., Weiner, J., Robinson, J. A., Hubbard, J. L., Torriani, M., et al. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy288 · Cited by 39
Immunotherapy and Microbiota for Targeting of Liver Tumor-Initiating Stem-like Cells
Machida, K., & Tahara, S. M. (2022) · Cancers · doi:10.3390/cancers14102381 · Cited by 35
Kohl, H. M., Castillo, A., & Ochoa‐Repáraz, J. (2020) · Diseases · doi:10.3390/diseases8030033 · Cited by 36
Metadata
- Authors
- Telesford, K. M., Yan, W., Ochoa-Reparaz, J., Pant, A., Kircher, C., Christy, M. A., Begum-Haque, S., Kasper, D. L., & Kasper, L. H.
- Affiliations
- Dartmouth College (US)
- Harvard University (US)
- Corresponding author
- Telesford, Kiel M
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2015-07-04
- Volume
- 6
- Issue
- 4
- Pages
- 234-242
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4615798
- OpenAlex
- W1894807755
- Cited by
- 252
- References
- 51
- Citations by year
- 2026: 14 · 2025: 30 · 2024: 22 · 2023: 26 · 2022: 28 · 2021: 27 · 2020: 20 · 2019: 21 · 2018: 20 · 2017: 22 · 2016: 22
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R41AI110170)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Bacteroides fragilis, polysaccharide A, regulatory T cells, Foxp3, CD39, commensal bacteria, gut microbiota, dendritic cells, IL-10, Treg suppressive function, autoimmune disease, multiple sclerosis, inflammatory bowel disease, Th17 cells
- MeSH terms
- Apyrase, Bacteroides fragilis, Cells, Cultured, Dendritic Cells, Humans, Lipopolysaccharides, Symbiosis, CD4-Positive T-Lymphocytes, Antigens, CD, Immunophenotyping, T-Lymphocyte Subsets, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
