Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3 + regulatory T cells
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Cell wall components of probiotic bacterium Bifidobacterium bifidum drive induction of regulatory T cells in the gut.
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Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269 · see citing works
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,255 · see citing works
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works
How colonization by microbiota in early life shapes the immune system
Gensollen, T., Iyer, S. S., Kasper, D. L., & Blumberg, R. S. (2016) · Science · doi:10.1126/science.aad9378 · Cited by 2,044 · see citing works
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works
Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452 · see citing works
The role of gut microbiota in immune homeostasis and autoimmunity
Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426 · see citing works
Peripheral education of the immune system by colonic commensal microbiota
Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034 · see citing works
Individual intestinal symbionts induce a distinct population of RORγ <sup>+</sup> regulatory T cells
Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879 · see citing works
The microbiota regulates type 2 immunity through RORγt <sup>+</sup> T cells
Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863 · see citing works
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
Maloy, K. J., Salaün, L., Cahill, R., Dougan, G., Saunders, N. J. S. G., & Powrie, F. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021345 · Cited by 740 · see citing works
Agrawal, S., Agrawal, A., Doughty, B. L., Gerwitz, A., Blenis, J., Dyke, T. E. V., & Pulendran, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4984 · Cited by 726 · see citing works
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
Shen, Y., Torchia, M. L. G., Lawson, G. W., Karp, C. L., Ashwell, J. D., & Mazmanian, S. K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.004 · Cited by 714 · see citing works
Fecal microbiota transplantation and emerging applications
Borody, T. J., & Khoruts, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.244 · Cited by 677 · see citing works
Kwon, H., Lee, C., So, J., Chae, C.-S., Hwang, J.-S., Sahoo, A., Nam, J. H., Rhee, J. H., Hwang, K.-C., & Im, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904055107 · Cited by 627 · see citing works
Self-citationWeiss, J. M., Bilate, A. M., Gobert, M., Ding, Y., Curotto de Lafaille, M. A., Parkhurst, C. N., Xiong, H., Dolpady, J., Frey, A. B., Ruocco, M. G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120914 · Cited by 621 · see citing works
tTregs, pTregs, and iTregs: similarities and differences
Shevach, E. M., & Thornton, A. M. (2014) · Immunological Reviews · doi:10.1111/imr.12160 · Cited by 607 · see citing works
Development and maintenance of intestinal regulatory T cells
Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553 · see citing works
Dillon, S. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27203 · Cited by 550 · see citing works
Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine
Kim, K. S., Hong, S., Han, D., Yi, J., Jung, J., Yang, B., Lee, J. Y., Lee, M., & Surh, C. D. (2016) · Science · doi:10.1126/science.aac5560 · Cited by 541 · see citing works
Self-citationRegulatory Lymphocytes and Intestinal Inflammation
Ízcue, A., Coombes, J. L., & Powrie, F. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 505 · see citing works
Yan, F., & Polk, D. B. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834baa4d · Cited by 447 · see citing works
Yang, B.-H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette, M., Föhse, L., Prinz, I., Pezoldt, J., Suerbaum, S., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.74 · Cited by 435 · see citing works
Intestinal Commensal Microbes as Immune Modulators
Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 425 · see citing works
Ochoa-Repáraz, J., Mielcarz, D. W., Ditrio, L. E., Burroughs, A. R., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001443 · Cited by 367 · see citing works
Kirjavainen, P. V., Arvola, T., Salminen, S., & Isolauri, E. (2002) · Gut · doi:10.1136/gut.51.1.51 · Cited by 354 · see citing works
T cells in inflammatory bowel disease: protective and pathogenic roles
Powrie, F. M. (1995) · Immunity · doi:10.1016/1074-7613(95)90086-1 · Cited by 351 · see citing works
Exploring the Diversity of the Bifidobacterial Population in the Human Intestinal Tract
Turroni, F., Foroni, E., Pizzetti, P., Giubellini, V., Ribbera, A., Merusi, P., Cagnasso, P., Bizzarri, B., de'Angelis, G. L., Shanahan, F., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02216-08 · Cited by 311 · see citing works
Manicassamy, S., Ravindran, R., Deng, J., Oluoch, H., Denning, T. L., Kasturi, S. P., Rosenthal, K. M., Evavold, B. D., & Pulendran, B. (2009) · Nature Medicine · doi:10.1038/nm.1925 · Cited by 298 · see citing works
Dasgupta, S., Erturk-Hasdemir, D., Ochoa-Reparaz, J., Reinecker, H.-C., & Kasper, D. L. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.006 · Cited by 292 · see citing works
Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man
Raker, V., Domogalla, M. P., & Steinbrink, K. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00569 · Cited by 262 · see citing works
Telesford, K. M., Yan, W., Ochoa-Reparaz, J., Pant, A., Kircher, C., Christy, M. A., Begum-Haque, S., Kasper, D. L., & Kasper, L. H. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1056973 · Cited by 252 · see citing works
Kwon, H.-K., Kim, G.-C., Kim, Y., Hwang, W., Jash, A., Sahoo, A., Kim, J.-E., Nam, J. H., & Im, S.-H. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.01.001 · Cited by 212 · see citing works
Self-citationThe yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA
Surana, N. K., & Kasper, D. L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01075.x · Cited by 153 · see citing works
Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India
Verma, R., Verma, A. K., Ahuja, V., & Paul, J. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01360-10 · Cited by 124 · see citing works
Self-citationSmith, B., Bodé, S., Petersen, B. L., Jensen, T. K., Pipper, C. B., Kloppenborg, J., Boyé, M., Krogfelt, K. A., & Mølbak, L. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-73 · Cited by 102 · see citing works
Edwards, J. P., Thornton, A. M., & Shevach, E. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401102 · Cited by 99 · see citing works
Kasper, D. L., Weintraub, A., Lindberg, A. A., & Lōnngren, J. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.2.991-997.1983 · Cited by 91 · see citing works
Cong, Y., Weaver, C. T., Lazenby, A. J., & Elson, C. O. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2173 · Cited by 90 · see citing works
Dinoto, A., Marques, T. M., Sakamoto, K., Fukiya, S., Watanabe, J., Ito, S., & Yokota, A. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01777-06 · Cited by 63 · see citing works
Prophylactic Effect of Probiotics on the Development of Experimental Autoimmune Myasthenia Gravis
Chae, C.-S., Kwon, H., Hwang, J., Kim, J., & Im, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052119 · Cited by 54 · see citing works
Self-citationYoshida, R., Yoshioka, T., Yamane, S., Matsutani, T., Toyosaki‐Maeda, T., Tsuruta, Y., & Suzuki, R. (2000) · Immunogenetics · doi:10.1007/s002510000248 · Cited by 51 · see citing works
Kim, J., Chae, C.-S., Kim, G.-C., Hwang, W., Hwang, J., Hwang, S., Kim, Y., Ahn, Y., Park, S., Jun, C., et al. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.01.002 · Cited by 50 · see citing works
Self-citationImmune Disorders and Its Correlation with Gut Microbiome
Hwang, J.-S., Im, C.-R., & Im, S. (2012) · Immune Network · doi:10.4110/in.2012.12.4.129 · Cited by 45 · see citing works
Self-citationEfficient Electrotransformation of Bacteroides fragilis
Ichimura, M., Nakayama‐Imaohji, H., Wakimoto, S., Morita, H., Hayashi, T., & Kuwahara, T. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02420-09 · Cited by 31 · see citing works
Choolani, M. A., Ho, S. S. Y., Razvi, K., Ponnusamy, S., Baig, S., Fisk, N. M., & Biswas, A. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam016 · Cited by 24 · see citing works
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Gaucher, F., Bonnassié, S., Rabah, H., Marchand, P., Blanc, P., Jeantet, R., & Jan, G. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00841 · Cited by 84 · see citing works
Self-citationKatoh, T., Ojima, M. N., Sakanaka, M., Ashida, H., Gotoh, A., & Katayama, T. (2020) · Microorganisms · doi:10.3390/microorganisms8040481 · Cited by 80 · see citing works
Fakharian, F., Asgari, B., Nabavi-Rad, A., Sadeghi, A., Soleimani, N., Yadegar, A., & Zali, M. R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953718 · Cited by 78 · see citing works
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Augustine, T., Kumar, M., Khodor, S. A., & van Panhuys, N. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-022-08939-9 · Cited by 75 · see citing works
Microbiota and Cancer: The Emerging Beneficial Role of Bifidobacteria in Cancer Immunotherapy
Longhi, G., van Sinderen, D., Ventura, M., & Turroni, F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.575072 · Cited by 71 · see citing works
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Garabatos, N., & Santamaría, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.873607 · Cited by 74 · see citing works
The microbial origins of food allergy
Rachid, R. A., Victor, E. S., & Chatila, T. A. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.12.624 · Cited by 69 · see citing works
Choi, S. H., Oh, J., Ryu, J. S., Kim, H. M., Im, S., Kim, K. P., & Kim, M. K. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.3.42 · Cited by 68 · see citing works
Self-citationZhu, R., Lang, T., Yan, W., Zhu, X. G., Huang, X. Y., Yin, Q., & Li, Y. (2021) · Advanced Science · doi:10.1002/advs.202003542 · Cited by 65 · see citing works
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Nam, J., Kim, A., Kim, K. H., Moon, J. H., Baig, J., Phoo, M. T., Moon, J. J., & Son, S. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00193-2 · Cited by 69 · see citing works
Self-citationMining chicken ileal microbiota for immunomodulatory microorganisms
Liu, Y., Feng, Y., Yang, X., Lv, Z., Li, P., Zhang, M., Wei, F., Jin, X., Hu, Y., Guo, Y., et al. (2023) · The ISME Journal · doi:10.1038/s41396-023-01387-z · Cited by 66 · see citing works
Wang, J., Hou, Y., Mu, L., Yang, M., & Ai, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113570 · Cited by 65 · see citing works
Zhang, H., Liu, M., Liu, X., Zhong, W., Li, Y., Ran, Y., Guo, L., Chen, X., Zhao, J., Wang, B., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.569104 · Cited by 61 · see citing works
The early-life gut microbiome and vaccine efficacy
Jordan, A., Carding, S. R., & Hall, L. J. (2022) · The Lancet Microbe · doi:10.1016/s2666-5247(22)00185-9 · Cited by 58 · see citing works
D’Amico, F., Perrone, A. M., Rampelli, S., Coluccelli, S., Barone, M., Ravegnini, G., Fabbrini, M., Brigidi, P., Iaco, P. D., & Turroni, S. (2021) · Cancers · doi:10.3390/cancers13163999 · Cited by 57 · see citing works
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Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 65 · see citing works
Self-citationQi, Y., He, J., Zhang, Y., Ge, Q., Wang, Q., Chen, L., Xu, J., Wang, L., Chen, X., Jia, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41827-0 · Cited by 55 · see citing works
Yin, R., Wang, T., Sun, J., Dai, H., Zhang, Y., Liu, N., & Liu, H. (2024) · Advanced Science · doi:10.1002/advs.202405781 · Cited by 60 · see citing works
Speciale, I., Verma, R. P., Lorenzo, F. D., Molinaro, A., Im, S., & Castro, C. D. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.05.006 · Cited by 53 · see citing works
Self-citationGarcía-Vello, P., Sharma, G., Speciale, I., Molinaro, A., Im, S., & Castro, C. D. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115857 · Cited by 53 · see citing works
Self-citationImmunomodulatory Roles of Polysaccharide Capsules in the Intestine
Hsieh, S. A., & Allen, P. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00690 · Cited by 49 · see citing works
Harness the functions of gut microbiome in tumorigenesis for cancer treatment
Lee, M. (2021) · Cancer Communications · doi:10.1002/cac2.12200 · Cited by 50 · see citing works
Regulatory T cells and their role in allergic disease
Conrad, M. L., Barrientos, G., Cai, X., Mukherjee, S., Das, M., Victor, E. S., & Harb, H. (2024) · Allergy · doi:10.1111/all.16326 · Cited by 47 · see citing works
Jensen, B. A. H., Holm, J. B., Larsen, I., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S., Rivollier, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21408-9 · Cited by 48 · see citing works
Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics
Ojima, M. N., Yoshida, K., Sakanaka, M., Jiang, L., Odamaki, T., & Katayama, T. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.06.023 · Cited by 46 · see citing works
Xia, L., Zhu, X., Wang, Y., & Lü, S. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217123 · Cited by 48 · see citing works
Ojima, M. N., Gotoh, A., Takada, H., Odamaki, T., Xiao, J., Katoh, T., & Katayama, T. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01349 · Cited by 45 · see citing works
Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics
Kim, T. K., Lee, J.-C., Im, S., & Lee, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01832 · Cited by 43 · see citing works
Self-citationHickey, A., Stamou, P., Udayan, S., Ramón-Vázquez, A., Esteban-Torres, M., Bottacini, F., Woznicki, J. A., Hughes, O., Melgar, S., Ventura, M., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.653587 · Cited by 40 · see citing works
Roles of the Cell Surface Architecture of Bacteroides and Bifidobacterium in the Gut Colonization
Nishiyama, K., Yokoi, T., Sugiyama, M., Osawa, R., Mukai, T., & Okada, N. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.754819 · Cited by 40 · see citing works
Intestinal barrier dysfunction as a key driver of severe COVID-19
Tsounis, E. P., Triantos, C. K., Konstantakis, C., Marangos, M. N., & Assimakopoulos, S. F. (2023) · World Journal of Virology · doi:10.5501/wjv.v12.i2.68 · Cited by 39 · see citing works
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Lee, C., Hyun, K., Kim, G.-C., Im, S., & Kwon, H. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad046 · Cited by 39 · see citing works
Self-citationHsieh, S. A., Porter, N. T., Donermeyer, D. L., Horvath, S. C., Strout, G. W., Saunders, B. T., Zhang, N., Zinselmeyer, B. H., Martens, E. C., Stappenbeck, T. S., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901206 · Cited by 38 · see citing works
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Geuking, M. B., & Burkhard, R. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00335-w · Cited by 37 · see citing works
Selle, A., Brosseau, C., Dijk, W., Duval, A., Bouchaud, G., Rousseaux, A., Bruneau, A., Cherbuy, C., Mariadassou, M., Cariou, V., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.745535 · Cited by 38 · see citing works
Sanchez, J. F., Maknojia, A., & King, K. Y. (2024) · Blood · doi:10.1182/blood.2023021174 · Cited by 37 · see citing works
Achi, S. C., Talahalli, R. R., & Halami, P. M. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09864-2 · Cited by 37 · see citing works
Rewiring host–microbe interactions and barrier function during gastrointestinal inflammation
Yang-Jensen, S. K., Pærregaard, S. I., Brandum, E. P., Jørgensen, A. S., Hjortø, G. M., & Jensen, B. A. H. (2022) · Gastroenterology report · doi:10.1093/gastro/goac008 · Cited by 36 · see citing works
Guo, M., Liu, X., Tan, Y., Kang, F.-Y., Zhu, X.-H., Fan, X., Wang, C., Wang, R., Liu, Y., Qin, X., et al. (2021) · Food & Function · doi:10.1039/d1fo01351c · Cited by 30 · see citing works
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Prasad, S., Singh, S., Menge, S., Mohapatra, I., Kim, S., Helland, L. C., Singh, G., & Singh, A. R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1387903 · Cited by 34 · see citing works
Treg‐inducing capacity of genomic DNA of Bifidobacterium longum subsp. infantis
Li, D., Cheng, J., Zhu, Z., Catálfamo, M., Goerlitz, D. S., Lawless, O. J., Tallon, L. J., Sadzewicz, L., Calderone, R., & Bellanti, J. A. (2020) · Allergy and Asthma Proceedings · doi:10.2500/aap.2020.41.200064 · Cited by 32 · see citing works
Larsen, I., Fritzen, A. M., Carl, C. S., Agerholm, M., Damgaard, M. V., Holm, J. B., Marette, A., Nordkild, P., Kiens, B., Kristiansen, K., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00019.2019 · Cited by 31 · see citing works
Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis
Gurczynski, S. J., Lipinski, J. H., Strauss, J., Alam, S., Huffnagle, G. B., Ranjan, P., Kennedy, L. H., Moore, B. B., & O’Dwyer, D. N. (2023) · JCI Insight · doi:10.1172/jci.insight.164572 · Cited by 31 · see citing works
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Lee, J., McClure, S., Weichselbaum, R. R., & Mimee, M. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115579 · Cited by 30 · see citing works
The gut-immune-brain axis in neurodevelopment and neurological disorders
Park, J. C., & Im, S. (2022) · Microbiome Research Reports · doi:10.20517/mrr.2022.11 · Cited by 32 · see citing works
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Zhang, J., Liu, H.-J., Chen, Y.-H., Liu, H., Zhang, S., Yin, G., & Xie, Q.-B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1312919 · Cited by 25 · see citing works
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Kim, J. E., Sharma, A., Sharma, G., Lee, S., Shin, H. S., Rudra, D., & Im, S. (2019) · Immune Network · doi:10.4110/in.2019.19.e39 · Cited by 28 · see citing works
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Bautista, J., Maldonado-Noboa, I., Maldonado-Guerrero, D., Reinoso-Quinga, L., & López‐Cortés, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1681824 · Cited by 28 · see citing works
Damage-free light-induced assembly of intestinal bacteria with a bubble-mimetic substrate
Hayashi, K., Yamamoto, Y., Tamura, M., Tokonami, S., & Iida, T. (2021) · Communications Biology · doi:10.1038/s42003-021-01807-w · Cited by 27 · see citing works
Wang, J., Zheng, S., Yang, X., Huazeng, B., & Cheng, Q. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105020 · Cited by 27 · see citing works
Regulation of T cell repertoires by commensal microbiota
Kim, K. S. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1004339 · Cited by 29 · see citing works
Self-citationYang, J., Kuang, H., Li, N., Hamdy, A. M., & Song, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2062294 · Cited by 26 · see citing works
Gut microbiome: A possible common therapeutic target for treatment of atherosclerosis and cancer
Wu, W., Ivanova, E. A., & Orekhov, A. N. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.017 · Cited by 26 · see citing works
Capsular polysaccarides of probiotics and their immunomodulatory roles
Li, J., Feng, S., Yu, L., Zhao, J., Tian, F., Chen, W., & Zhai, Q. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.04.003 · Cited by 25 · see citing works
Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders
Lee, C., Kim, S. W., Verma, R. P., Noh, J., Park, J. C., Park, S., Lee, H., Park, H. E., Kim, C. J., Byun, S., et al. (2024) · Nutrients · doi:10.3390/nu16060790 · Cited by 24 · see citing works
Self-citationEslami, M., Adampour, Z., Dowlat, B. F., Yaghmayee, S., Tabaei, F. M., Oksenych, V., & Naderian, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040915 · Cited by 26 · see citing works
Figliuolo, V. R., Jamwal, D. R., & Kiela, P. R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6407-9_9 · Cited by 27 · see citing works
Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies
Kreft, L., Hoffmann, C., & Ohnmacht, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01853 · Cited by 23 · see citing works
(R)Evolution in Allergic Rhinitis Add-On Therapy: From Probiotics to Postbiotics and Parabiotics
Capponi, M., Gori, A., Castro, G. D., Ciprandi, G., Anania, C., Brindisi, G., Tosca, M., Cinicola, B. L., Salvatori, A., Loffredo, L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175154 · Cited by 24 · see citing works
Defining Dysbiosis in Inflammatory Bowel Disease
de Jong, R. J., & Ohnmacht, C. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.028 · Cited by 23 · see citing works
Kim, H. W., Ju, D. B., Kye, Y.-C., Ju, Y.-J., Kim, C. G., Lee, I. K., Park, S., Choi, I. S., Cho, K. K., Lee, S. H., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03063 · Cited by 22 · see citing works
- Authors
- Verma, R., Lee, C., Jeun, E.-J., Yi, J., Kim, K. S., Ghosh, A., Byun, S., Lee, C.-G., Kang, H.-J., Kim, G.-C., Jun, C.-D., Jan, G., Suh, C.-H., Jung, J.-Y., Sprent, J., Rudra, D., De Castro, C., Molinaro, A., Surh, C. D., & Im, S.-H.
- Affiliations
- Institute for Basic Science (KR)
- Pohang University of Science and Technology (KR)
- Gwangju Institute of Science and Technology (KR)
- INRA-Agrocampus Ouest Rennes, UMR 1253 STLO, Rennes, France.
- Ajou University (KR)
- Department of Agricultural Sciences, University of Napoli, 80055 Portici, Italy.
- University of Naples Federico II (IT)
- Corresponding author
- Im, Sin-Hyeog
- ORCID
- Venue
- Science Immunology
- Published
- 2018-10-26
- Volume
- 3
- Issue
- 28
- Pages
- eaat6975
- ISSN
- 2470-9468 (ISSN-L)
- OpenAlex
- W2897482184
- Cited by
- 242
- References
- 55
- Citations by year
- 2026: 26 · 2025: 37 · 2024: 36 · 2023: 31 · 2022: 25 · 2021: 28 · 2020: 30 · 2019: 27 · 2018: 2
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- cc-by
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- Institute for Basic Science, Korea (IBS-R005)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium bifidum, cell surface polysaccharides, regulatory T cells, Foxp3, immunomodulation, gut microbiota, bacterial polysaccharides
- MeSH terms
- Bifidobacterium bifidum, Animals, Inflammation, Mice, Inbred C57BL, Polysaccharides, Mice, Knockout, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors
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