The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice
Open accessAbstract
Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction. However, the mechanism of spermidine on obesity remains unclear. Here, we show that spermidine intake is negatively correlated with obesity in both humans and mice. Spermidine supplementation causes a significant loss of weight and improves insulin resistance in diet-induced obese (DIO) mice. These effects are associated with the alleviation of metabolic endotoxemia and enhancement of intestinal barrier function, which might be mediated through autophagy pathway and TLR4-mediated microbial signaling transduction. Moreover, spermidine causes the significant alteration of microbiota composition and function. Microbiota depletion compromises function, while transplantation of spermidine-altered microbiota confers protection against obesity. These changes might partly be driven by an SCFA-producing bacterium, Lachnospiraceae NK4A136 group, which was decreased in obese subjects and subsequently increased by spermidine. Notably, the change of Lachnospiraceae NK4A136 group is significantly correlated with enhanced gut barrier function induced by spermidine. Our results indicate that spermidine supplementation may serve as a viable therapy for obesity.
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Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Induction of autophagy by spermidine promotes longevity
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“Spermidine was detected by HPLC/MS according to methods described previously with slight modifications.(49) All experiments were carried out on an Agilent 1290 Infinity Series and Triple Quadrupole 6420 from Agilent Technology (Santa Clara, CA, USA).”
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Cardioprotection and lifespan extension by the natural polyamine spermidine
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Cited by
Li, P., Wang, H., Guo, L., Gou, X., Chen, G., Lin, D., Fan, D., Guo, X., & Liu, Z. (2022) · BMC Medicine · doi:10.1186/s12916-022-02657-x · Cited by 561
Gut barrier disruption and chronic disease
Martel, J., Chang, S.-H., Ko, Y.-F., Hwang, T.-L., Young, J. D., & Ojcius, D. M. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.002 · Cited by 514
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361
RetractedVersatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
Wang, X., Lin, S., Wang, L., Cao, Z., Zhang, M., Zhang, Y., Liu, R., & Liu, J. (2023) · Science Advances · doi:10.1126/sciadv.ade5079 · Cited by 220
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment
Terrisse, S., Derosa, L., Iebba, V., Ghiringhelli, F., Vaz-Luis, I., Kroemer, G., Fidelle, M., Christodoulidis, S., Segata, N., Thomas, A. M., et al. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00784-1 · Cited by 172
Metadata
- Authors
- Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., & Fu, Z.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2020-11-05
- Volume
- 12
- Issue
- 1
- Pages
- 1832857
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W3095845746
- Cited by
- 593
- References
- 53
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., & Fu, Z. (2020). Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice. Gut Microbes. https://doi.org/10.1080/19490976.2020.1832857
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