Formation of propionate and butyrate by the human colonic microbiota

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

KEGG as a reference resource for gene and protein annotation

Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1070 · Cited by 7,387 · see citing works

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,836 · see citing works

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179 · see citing works

Regulation of short-chain fatty acid production

Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., et al. (2016) · Science · doi:10.1126/science.aad3369 · Cited by 1,914 · see citing works

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · see citing works

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Reichardt, N., Duncan, S. H., Young, P., Belenguer, Á., Leitch, E. C. M., Scott, K. P., Flint, H. J., & Louis, P. (2014) · The ISME Journal · doi:10.1038/ismej.2014.14 · Cited by 1,302 · see citing works

Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation

Browne, H. P., Forster, S. C., Anonye, B. O., Kumar, N., Neville, B. A., Stares, M. D., Goulding, D., & Lawley, T. D. (2016) · Nature · doi:10.1038/nature17645 · Cited by 1,299 · see citing works

Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data

Vital, M., Howe, A. C., & Tiedje, J. M. (2014) · mBio · doi:10.1128/mbio.00889-14 · Cited by 1,189 · see citing works

Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product

Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,124 · see citing works

Links between diet, gut microbiota composition and gut metabolism

Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2015) · Proceedings of the Nutrition Society · doi:10.1017/s0029665114001463 · Cited by 1,020 · see citing works

Phylogenetic Relationships of Butyrate-Producing Bacteria from the Human Gut

Barcenilla, A., Pryde, S. E., Martin, J. C., Duncan, S. H., Stewart, C. S., Henderson, C., & Flint, H. J. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.4.1654-1661.2000 · Cited by 996 · see citing works

Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces

Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941 · see citing works

Lactic metabolism revisited: metabolism of lactic acid bacteria in food fermentations and food spoilage.

Gänzle, M. G. (2015) · Current Opinion in Food Science · doi:10.1016/j.cofs.2015.03.001 · Cited by 936 · see citing works

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii , a commensal bacterium deficient in Crohn’s disease

Quévrain, E., Maubert, M.-A., Michon, C., Chain, F., Marquant, R., Tailhades, J., Miquel, S., Carlier, L., Bermúdez‐Humarán, L. G., Pigneur, B., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307649 · Cited by 861 · see citing works

Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation

Buckel, W., & Thauer, R. K. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.07.002 · Cited by 797 · see citing works

pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon

Walker, A. W., Duncan, S. H., McWilliam Leitch, E. C., Child, M. W., & Flint, H. J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.3692-3700.2005 · Cited by 796 · see citing works

The role of pH in determining the species composition of the human colonic microbiota

Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786 · see citing works

Diversity of human colonic butyrate‐producing bacteria revealed by analysis of the butyryl‐CoA:acetate CoA‐transferase gene

Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works

High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775 · see citing works

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

Vadder, F. D., Kovatcheva‐Datchary, P., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.013 · Cited by 756 · see citing works

Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men

Salonen, A., Lahti, L., Salojärvi, J., Holtrop, G., Korpela, K., Duncan, S. H., Date, P., Farquharson, F., Johnstone, A. M., Lobley, G. E., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.63 · Cited by 626 · see citing works

Amino acid metabolism in intestinal bacteria: links between gut ecology and host health

Dai, Z. (2010) · Frontiers in bioscience · doi:10.2741/3820 · Cited by 563 · see citing works

Microbial pathways in colonic sulfur metabolism and links with health and disease

Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544 · see citing works

Restricted Distribution of the Butyrate Kinase Pathway among Butyrate-Producing Bacteria from the Human Colon

Louis, P., Duncan, S. H., McCrae, S. I., Millar, J., Jackson, M. S., & Flint, H. J. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.7.2099-2106.2004 · Cited by 517 · see citing works

Role of glutamate metabolism in bacterial responses towards acid and other stresses

Feehily, C., & Karatzas, K. A. G. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05434.x · Cited by 457 · see citing works

Amino Acid Degradation by Anaerobic Bacteria

Barker, H. A. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.000323 · Cited by 447 · see citing works

Cultured Representatives of Two Major Phylogroups of Human Colonic Faecalibacterium prausnitzii Can Utilize Pectin, Uronic Acids, and Host-Derived Substrates for Growth

Lopez-Siles, M., Khan, T. M., Duncan, S. H., Harmsen, H. J. M., Garcia-Gil, L. J., & Flint, H. J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.06858-11 · Cited by 433 · see citing works

Modulation of the human gut microbiota by dietary fibres occurs at the species level

Chung, W. S. F., Walker, A. W., Louis, P., Parkhill, J., Vermeiren, J., Bosscher, D., Duncan, S. H., & Flint, H. J. (2016) · BMC Biology · doi:10.1186/s12915-015-0224-3 · Cited by 409 · see citing works

Dissimilatory Amino Acid Metabolism in Human Colonic Bacteria

Smith, E. A., & Macfarlane, G. T. (1997) · Anaerobe · doi:10.1006/anae.1997.0121 · Cited by 388 · see citing works

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

Ferreyra, J. A., Wu, K. J., Hryckowian, A. J., Bouley, D. M., Weimer, B. C., & Sonnenburg, J. L. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.11.003 · Cited by 382 · see citing works

The Common Gut Microbe Eubacterium hallii also Contributes to Intestinal Propionate Formation

Engels, C., Ruscheweyh, H.-J., Beerenwinkel, N., Lacroix, C., & Schwab, C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00713 · Cited by 372 · see citing works

Butyricicoccus pullicaecorum in inflammatory bowel disease

Eeckhaut, V., Machiels, K., Perrier, C., Romero, C., Maes, S., Flahou, B., Steppe, M., Haesebrouck, F., Sas, B., Ducatelle, R., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-303611 · Cited by 368 · see citing works

Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident

Bourriaud, C., Robins, R. J., Martin, L., Kozlowski, F., Tenailleau, E., Cherbut, C., & Michel, C. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02605.x · Cited by 345 · see citing works

The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases

Khan, M. T., Duncan, S. H., Stams, A. J. M., van Dijl, J. M., Flint, H. J., & Harmsen, H. J. M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.5 · Cited by 339 · see citing works

Human Colonic Bacteria: Role in Nutrition, Physiology, and Pathology

Gibson, G. R., & Macfarlane, G. T. (1995) · Cited by 286 · see citing works

Whole-Genome Transcription Profiling Reveals Genes Up-Regulated by Growth on Fucose in the Human Gut Bacterium “Roseburia inulinivorans”

Scott, K. P., Martin, J. C., Campbell, G. P., Mayer, C., & Flint, H. J. (2006) · Journal of Bacteriology · doi:10.1128/jb.00137-06 · Cited by 282 · see citing works

Enumeration of amino acid fermenting bacteria in the human large intestine: effects of pH and starch on peptide metabolism and dissimilation of amino acids

Smith, E. A., & Macfarlane, G. T. (1998) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.1998.tb00487.x · Cited by 277 · see citing works

Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal

Bui, T. P. N., Ritari, J., Boeren, S. A., de Waard, P., Plugge, C. M., & de Vos, W. M. (2015) · Nature Communications · doi:10.1038/ncomms10062 · Cited by 272 · see citing works

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes

Sheridan, P. O., Martin, J. C., Lawley, T. D., Browne, H. P., Harris, H. M. B., Bernalier‐Donadille, A., Duncan, S. H., O’Toole, P. W., Scott, K. P., & Flint, H. J. (2015) · Microbial Genomics · doi:10.1099/mgen.0.000043 · Cited by 268 · see citing works

The Pharmacology and Function of Receptors for Short-Chain Fatty Acids

Bolognini, D., Tobin, A. B., Milligan, G., & Hodge, D. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.102301 · Cited by 267 · see citing works

Characterization of Phascolarctobacterium succinatutens sp. nov., an Asaccharolytic, Succinate-Utilizing Bacterium Isolated from Human Feces

Watanabe, Y., Nagai, F., & Morotomi, M. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06035-11 · Cited by 255 · see citing works

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250 · see citing works

Diverse Bacterial Microcompartment Organelles

Chowdhury, C., Sinha, S., Chun, S., et al. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00009-14 · Cited by 240 · see citing works

Impact of pH on Lactate Formation and Utilization by Human Fecal Microbial Communities

Belenguer, Á., Duncan, S. H., Holtrop, G., Anderson, S. E., Lobley, G. E., & Flint, H. J. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00508-07 · Cited by 240 · see citing works

Phylogeny, culturing, and metagenomics of the human gut microbiota

Walker, A. W., Duncan, S. H., Louis, P., & Flint, H. J. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.03.001 · Cited by 239 · see citing works

A novel mode of lactate metabolism in strictly anaerobic bacteria

Schoelmerich, M. C., Bertsch, J., & Müller, V. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12493 · Cited by 229 · see citing works

Iron Depletion and Repletion with Ferrous Sulfate or Electrolytic Iron Modifies the Composition and Metabolic Activity of the Gut Microbiota in Rats3

Dostal, A., Chassard, C., Hilty, F. M., Zimmermann, M. B., Jaeggi, T., Rossi, S., & Lacroix, C. (2011) · Journal of Nutrition · doi:10.3945/jn.111.148643 · Cited by 224 · see citing works

Bacterial Metabolism

Gottschalk, G. (1979) · Springer series in microbiology · doi:10.1007/978-1-4684-0465-4 · Cited by 219 · see citing works

Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate?

Morrison, D. J., Mackay, W. G., Edwards, C. A., Preston, T., Dodson, B., & Weaver, L. T. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061853 · Cited by 194 · see citing works

Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov

Duncan, S. H. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.02241-0 · Cited by 184 · see citing works

Carbohydrate Fermentation, Energy Transduction and Gas Metabolism in the Human Large Intestine

Macfarlane, G. T., & Gibson, G. R. (1997) · Springer eBooks · doi:10.1007/978-1-4615-4111-0_9 · Cited by 174 · see citing works

Vitamin B12-dependent propionate production by the ruminal bacterium Prevotella ruminicola 23

Strobel, H. J. (1992) · Applied and Environmental Microbiology · doi:10.1128/aem.58.7.2331-2333.1992 · Cited by 169 · see citing works

Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species

Muñoz‐Tamayo, R., Laroche, B., Walter, É., Dore, J. M., Duncan, S. H., Flint, H. J., & Leclerc, M. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01085.x · Cited by 164 · see citing works

H2metabolism is widespread and diverse among human colonic microbes

Wolf, P. G., Biswas, A., Morales, S. E., Greening, C., & Gaskins, H. R. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1182288 · Cited by 153 · see citing works

Unusual enzymes involved in five pathways of glutamate fermentation

Buckel, W. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100773 · Cited by 152 · see citing works

Modelling the emergent dynamics and major metabolites of the human colonic microbiota

Kettle, H., Louis, P., Holtrop, G., Duncan, S. H., & Flint, H. J. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12599 · Cited by 149 · see citing works

Microbial production and applications of 1,2-propanediol

Saxena, R. K., Anand, P., Saran, S., Isar, J., & Agarwal, L. (2010) · Indian Journal of Microbiology · doi:10.1007/s12088-010-0017-x · Cited by 147 · see citing works

Butyrate production in phylogenetically diverse Firmicutes isolated from the chicken caecum

Eeckhaut, V., Immerseel, F. V., Croubels, S., Baere, S. D., Haesebrouck, F., Ducatelle, R., Louis, P., & Vandamme, P. A. R. (2011) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2010.00244.x · Cited by 143 · see citing works

Iron Modulates Butyrate Production by a Child Gut Microbiota In Vitro

Dostal, A., Lacroix, C., Bircher, L., Pham, V. T., Follador, R., Zimmermann, M. B., & Chassard, C. (2015) · mBio · doi:10.1128/mbio.01453-15 · Cited by 134 · see citing works

Faecalicoccus acidiformans gen. nov., sp. nov., isolated from the chicken caecum, and reclassification of Streptococcus pleomorphus (Barnes et al. 1977), Eubacterium biforme (Eggerth 1935) and Eubacterium cylindroides (Cato et al. 1974) as Faecalicoccus pleomorphus comb. nov., Holdemanella biformis gen. nov., comb. nov. and Faecalitalea cylindroides gen. nov., comb. nov., respectively, within the family Erysipelotrichaceae

Maesschalck, C. D., Immerseel, F. V., Eeckhaut, V., et al. (2014) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.064626-0 · Cited by 112 · see citing works

Anaerostipes hadrus comb. nov., a dominant species within the human colonic microbiota; reclassification of Eubacterium hadrum Moore et al. 1976

Allen‐Vercoe, E., Daigneault, M. C., White, A. P., Panaccione, R., Duncan, S. H., Flint, H. J., O’Neal, L., & Lawson, P. A. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.09.002 · Cited by 109 · see citing works

Microbial formation, biotechnological production and applications of 1,2-propanediol

Bennett, G. N., & San, K. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000476 · Cited by 86 · see citing works

A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria

Charrier, C., Duncan, G., Reid, M., Rucklidge, G. J., Henderson, D., Young, P., Russell, V. J., Aminov, R. I., Flint, H. J., & Louis, P. (2005) · Microbiology · doi:10.1099/mic.0.28412-0 · Cited by 84 · see citing works

Anaerostipes rhamnosivorans sp. nov., a human intestinal, butyrate-forming bacterium

Bui, T. P. N., de Vos, W. M., & Plugge, C. M. (2013) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.055061-0 · Cited by 81 · see citing works

Faecal DL-Lactate Concentration in 100 Gastrointestinal Patients

Hove, H., Nordgaard-Andersen, I., & Mortensen, P. B. (1994) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529409090473 · Cited by 78 · see citing works

Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria

Rodionova, I. A., Li, X., Thiel, V., Stolyar, S. M., Stanton, K. C., Fredrickson, J. K., Bryant, D. A., Osterman, A. L., Best, A. A., & Rodionov, D. A. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00407 · Cited by 69 · see citing works

Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium

Potrykus, J., White, R. L., & Bearne, S. L. (2008) · PROTEOMICS · doi:10.1002/pmic.200700437 · Cited by 68 · see citing works

The role of carbon dioxide in glucose metabolism of Bacteroides fragilis

Caspari, D., & Macy, J. M. (1983) · Archives of Microbiology · doi:10.1007/bf00419476 · Cited by 54 · see citing works

Exogenous or l -Rhamnose-Derived 1,2-Propanediol Is Metabolized via a pduD -Dependent Pathway in Listeria innocua

Xue, J., Murrieta, C. M., Rule, D. C., et al. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01074-08 · Cited by 30 · see citing works

Biodiversity of Intestinal Lactic Acid Bacteria in the Healthy Population

Mikelsaar, M., Sepp, E., Štšepetova, J., Songisepp, E., & Mändar, R. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_3 · Cited by 29 · see citing works

Acyl-CoA reductase PGN_0723 utilizes succinyl-CoA to generate succinate semialdehyde in a butyrate-producing pathway of Porphyromonas gingivalis

Yoshida, Y., Sato, M., Kezuka, Y., et al. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.03.014 · Cited by 9 · see citing works

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works

Introduction to the human gut microbiota

Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600 · see citing works

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works

Gut microbiota functions: metabolism of nutrients and other food components

Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878 · see citing works

Gut microbiome and health: mechanistic insights

de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388 · see citing works

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0350-x · Cited by 1,539 · see citing works

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

Oliphant, K., & Allen-Vercoe, E. (2019) · Microbiome · doi:10.1186/s40168-019-0704-8 · Cited by 1,327 · see citing works

Impact of Omega-3 Fatty Acids on the Gut Microbiota

Costantini, L., Molinari, R., Farinon, B., & Merendino, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122645 · Cited by 741 · see citing works

Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation

Bach Knudsen, K. E., Lærke, H. N., Hedemann, M. S., Nielsen, T. S., Ingerslev, A. K., Gundelund Nielsen, D. S., Theil, P. K., Purup, S., Hald, S., Schioldan, A. G., et al. (2018) · Nutrients · doi:10.3390/nu10101499 · Cited by 572 · see citing works

Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection

Ducarmon, Q. R., Zwittink, R. D., Hornung, B. V. H., van Schaik, W., Young, V. B., & Kuijper, E. J. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00007-19 · Cited by 566 · see citing works

The Gut Microbiome, Aging, and Longevity: A Systematic Review

Badal, V. D., Vaccariello, E. D., Murray, E. R., Yu, K. E., Knight, R., Jeste, D. V., & Nguyen, T. T. (2020) · Nutrients · doi:10.3390/nu12123759 · Cited by 551 · see citing works

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Dizman, N., Meza, L., Bergerot, P., Alcantara, M., Dorff, T., Lyou, Y., Frankel, P., Cui, Y., Mira, V., Llamas, M., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01694-6 · Cited by 515 · see citing works

Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria

Fu, X., Liu, Z., Zhu, C., Mou, H., & Kong, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1542587 · Cited by 497 · see citing works

The rumen microbiome: balancing food security and environmental impacts

Mizrahi, I., Wallace, R. J., & Moraïs, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00543-6 · Cited by 490 · see citing works

Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer

Zeng, H., Umar, S., Rust, B., Lazarova, D., & Bordonaro, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051214 · Cited by 480 · see citing works

Microbial modulation of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440 · see citing works

Potential Industrial Applications and Commercialization of Microalgae in the Functional Food and Feed Industries: A Short Review

Camacho, F., Macedo, A., & Malcata, F. (2019) · Marine Drugs · doi:10.3390/md17060312 · Cited by 409 · see citing works

Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling

Jian, C., Luukkonen, P., Yki-Järvinen, H., Salonen, A., & Korpela, K. (2020) · PLOS ONE · doi:10.1371/journal.pone.0227285 · Cited by 384 · see citing works

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works

Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors

Nomura, M., Nagatomo, R., Doi, K., Shimizu, J., Baba, K., Saito, T., Matsumoto, S., Inoue, K., & Muto, M. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.2895 · Cited by 396 · see citing works

Modulating the microbiome to improve therapeutic response in cancer

McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works

Immune regulation by microbiome metabolites

Kim, C. H. (2018) · Immunology · doi:10.1111/imm.12930 · Cited by 375 · see citing works

Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid

Yuille, S., Reichardt, N., Panda, S., Dunbar, H., & Mulder, I. E. (2018) · PLOS ONE · doi:10.1371/journal.pone.0201073 · Cited by 257 · see citing works

Insect-based diet, a promising nutritional source, modulates gut microbiota composition and SCFAs production in laying hens.

Borrelli, L., Coretti, L., Dipineto, L., Bovera, F., Menna, F., Chiariotti, L., Nizza, A., Lembo, F., & Fioretti, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-16560-6 · Cited by 263 · see citing works

Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production

Reichardt, N., Vollmer, M., Holtrop, G., Farquharson, F. M., Wefers, D., Bunzel, M., Duncan, S. H., Drew, J. E., Williams, L. M., Milligan, G., et al. (2018) · The ISME Journal · doi:10.1038/ismej.2017.196 · Cited by 249 · see citing works

Leveraging diet to engineer the gut microbiome

Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works

The function of gut microbiota in immune-related neurological disorders: a review

Sittipo, P., Choi, J., Lee, S., & Lee, Y. K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02510-1 · Cited by 221 · see citing works

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

Botticelli, A., Vernocchi, P., Marini, F., Quagliariello, A., Cerbelli, B., Reddel, S., Del Chierico, F., Di Pietro, F., Giusti, R., Tomassini, A., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02231-0 · Cited by 209 · see citing works

The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping

Beresford-Jones, B. S., Forster, S. C., Stares, M. D., Notley, G., Viciani, E., Browne, H. P., Boehmler, D. J., Soderholm, A. T., Kumar, N., Vervier, K., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.003 · Cited by 194 · see citing works

Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?

Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P. (2019) · Experimental Dermatology · doi:10.1111/exd.14016 · Cited by 189 · see citing works

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

Worby, C. J., Schreiber, H. L., Straub, T. J., van Dijk, L. R., Bronson, R. A., Olson, B. S., Pinkner, J. S., Obernuefemann, C. L. P., Muñoz, V. L., Paharik, A. E., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01107-x · Cited by 188 · see citing works

Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

Granado-Serrano, A. B., Martín-Garí, M., Sánchez, V., Riart Solans, M., Berdún, R., Ludwig, I. A., Rubió, L., Vilaprinyó, E., Portero-Otín, M., & Serrano, J. C. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-38874-3 · Cited by 169 · see citing works

Understanding the prebiotic potential of different dietary fibers using an in vitro continuous adult fermentation model (PolyFermS)

Poeker, S. A., Geirnaert, A., Berchtold, L., Greppi, A., Krych, L., Steinert, R. E., de Wouters, T., & Lacroix, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-22438-y · Cited by 176 · see citing works

Syntrophy via Interspecies H ₂ Transfer between <i>Christensenella</i> and <i>Methanobrevibacter</i> Underlies Their Global Cooccurrence in the Human Gut

Ruaud, A., Esquivel-Elizondo, S., de la Cuesta-Zuluaga, J., Waters, J. L., Angenent, L. T., Youngblut, N. D., & Ley, R. E. (2020) · mBio · doi:10.1128/mbio.03235-19 · Cited by 149 · see citing works

The impact of nutrition on intestinal bacterial communities

Flint, H. J., Duncan, S. H., & Louis, P. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.04.005 · Cited by 149 · see citing works

A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis

Di Gioia, D., Bozzi Cionci, N., Baffoni, L., Amoruso, A., Pane, M., Mogna, L., Gaggìa, F., Lucenti, M. A., Bersano, E., Cantello, R., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01607-9 · Cited by 151 · see citing works

The human gut microbiota in people with amyotrophic lateral sclerosis

Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., et al. (2021) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1828475 · Cited by 123 · see citing works

Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

Huber-Ruano, I., Calvo, E., Mayneris-Perxachs, J., Rodríguez-Peña, M.-M., Ceperuelo-Mallafré, V., Cedó, L., Núñez-Roa, C., Miro-Blanch, J., Arnoriaga-Rodríguez, M., Balvay, A., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01306-y · Cited by 122 · see citing works

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

Valles-Colomer, M., Menni, C., Berry, S. E., Valdes, A. M., Spector, T. D., & Segata, N. (2023) · Nature Medicine · doi:10.1038/s41591-023-02260-4 · Cited by 114 · see citing works

Beneficial effects of butyrate on brain functions: A view of epigenetic

Alpino, G. D. C. Á., Pereira-Sol, G. A., Dias, M. D. M. E., Aguiar, A. S. D., & Peluzio, M. D. C. G. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2137776 · Cited by 110 · see citing works

Cultured microbes represent a substantial fraction of the human and mouse gut microbiota

Lagkouvardos, I., Overmann, J., & Clavel, T. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1320468 · Cited by 104 · see citing works

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang, C. H., Oh, J., Lim, J. S., Kim, H. J., & Kim, J.-S. (2021) · Foods · doi:10.3390/foods10030636 · Cited by 100 · see citing works

Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization

Horrocks, V., King, O. G., Yip, A. Y. G., Marques, I. M., & McDonald, J. A. K. (2023) · Microbiology · doi:10.1099/mic.0.001377 · Cited by 104 · see citing works

Incretins in obesity and diabetes

Chia, C. W., & Egan, J. M. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14211 · Cited by 93 · see citing works

Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism

Houghton, M. J., Kerimi, A., Mouly, V., Tumova, S., & Williamson, G. (2019) · The FASEB Journal · doi:10.1096/fj.201801209r · Cited by 92 · see citing works

Microbiota, microbial metabolites, and barrier function in a patient with anorexia nervosa after fecal microbiota transplantation

Prochazkova, P., Roubalova, R., Dvorak, J., Tlaskalova-Hogenova, H., Cermakova, M., Tomasova, P., Sediva, B., Kuzma, M., Bulant, J., Bilej, M., et al. (2019) · Microorganisms · doi:10.3390/microorganisms7090338 · Cited by 93 · see citing works

The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids

Vijay, A., Kouraki, A., Gohir, S., Turnbull, J., Kelly, A., Chapman, V., Barrett, D. A., Bulsiewicz, W. J., & Valdes, A. M. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1997559 · Cited by 93 · see citing works

MiMeNet: Exploring microbiome-metabolome relationships using neural networks

Reiman, D., Layden, B. T., & Dai, Y. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009021 · Cited by 80 · see citing works

Polymannuronic acid prevents dopaminergic neuronal loss via brain-gut-microbiota axis in Parkinson's disease model

Dong, X.-L., Wang, X., Liu, F., Liu, X., Du, Z.-R., Li, R. W., Xue, C.-H., Wong, K.-H., Wong, W.-T., Zhao, Q., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.180 · Cited by 75 · see citing works

Gut Feelings Begin in Childhood: the Gut Metagenome Correlates with Early Environment, Caregiving, and Behavior

Flannery, J. E., Stagaman, K., Burns, A. R., Hickey, R. J., Roos, L. E., Giuliano, R. J., Fisher, P. A., & Sharpton, T. J. (2020) · mBio · doi:10.1128/mbio.02780-19 · Cited by 75 · see citing works

A Novel Non-Digestible, Carrot-Derived Polysaccharide (cRG-I) Selectively Modulates the Human Gut Microbiota while Promoting Gut Barrier Integrity: An Integrated In Vitro Approach

Van den Abbeele, P., Verstrepen, L., Ghyselinck, J., Albers, R., Marzorati, M., & Mercenier, A. (2020) · Nutrients · doi:10.3390/nu12071917 · Cited by 73 · see citing works

Short-chain fatty acids: Important components of the gut-brain axis against AD

Huang, Y., Wang, Y. F., Miao, J., Zheng, R. F., & Li, J. Y. (2024) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2024.116601 · Cited by 70 · see citing works

Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations

Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works

Targeting the Gut Microbiome to Mitigate Immunotherapy-Induced Colitis in Cancer

Chang, A. E., Golob, J. L., Schmidt, T. M., Peltier, D. C., Lao, C. D., & Tewari, M. (2021) · Trends in Cancer · doi:10.1016/j.trecan.2021.02.005 · Cited by 62 · see citing works

The Role of the Microbiota–Gut–Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

Obrenovich, M., Jaworski, H., Tadimalla, T., Mistry, A., Sykes, L., Perry, G., & Bonomo, R. (2020) · Microorganisms · doi:10.3390/microorganisms8050784 · Cited by 62 · see citing works

Carrot RG-I Reduces Interindividual Differences between 24 Adults through Consistent Effects on Gut Microbiota Composition and Function Ex Vivo

Van den Abbeele, P., Deyaert, S., Albers, R., Baudot, A., & Mercenier, A. (2023) · Nutrients · doi:10.3390/nu15092090 · Cited by 46 · see citing works

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

Baldewijns, S., Sillen, M., Palmans, I., Vandecruys, P., Van Dijck, P., & Demuyser, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.705779 · Cited by 44 · see citing works

Gut Microbiota and Autism Spectrum Disorder: A Neuroinflammatory Mediated Mechanism of Pathogenesis?

Zarimeidani, F., Rahmati, R., Mostafavi, M., Darvishi, M., Khodadadi, S., Mohammadi, M., Shamlou, F., Bakhtiyari, S., & Alipourfard, I. (2024) · Inflammation · doi:10.1007/s10753-024-02061-y · Cited by 47 · see citing works

The Many Faces of Microbiota-Gut-Brain Axis in Autism Spectrum Disorder

Gonçalves, C. L., Doifode, T., Rezende, V. L., Costa, M. A., Rhoads, J. M., & Soutullo, C. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122357 · Cited by 42 · see citing works

Consistent Prebiotic Effects of Carrot RG-I on the Gut Microbiota of Four Human Adult Donors in the SHIME® Model despite Baseline Individual Variability

Van den Abbeele, P., Duysburgh, C., Cleenwerck, I., Albers, R., Marzorati, M., & Mercenier, A. (2021) · Microorganisms · doi:10.3390/microorganisms9102142 · Cited by 31 · see citing works

Are nonnutritive sweeteners obesogenic? Associations between diet, faecal microbiota, and short-chain fatty acids in morbidly obese subjects

Farup, P. G., Lydersen, S., & Valeur, J. (2019) · Journal of Obesity · doi:10.1155/2019/4608315 · Cited by 29 · see citing works

A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome

Casaro, M. B., Thomas, A. M., Mendes, E., Fukumori, C., Ribeiro, W. R., Oliveira, F. A., Crisma, A. R., Murata, G. M., Bizzarro, B., Sá-Nunes, A., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01081-2 · Cited by 24 · see citing works

Genomic and functional diversity of the human-derived isolates of Faecalibacterium

Li, W., Lin, X., Liang, H., Wu, Z., Wang, M., Sun, J., Li, X., He, W., Gao, X., Hu, T., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1379500 · Cited by 17 · see citing works

Microbiota and enteric nervous system crosstalk in diabetic gastroenteropathy: bridging mechanistic insights to microbiome-based therapies

Tao, W., Yu, Y., Tan, D., Huang, X., Huang, J., Lin, C., & Yu, R. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1603442 · Cited by 9 · see citing works

Effects of Resistant Starch on Symptoms, Fecal Markers and Gut Microbiota in Parkinson’s Disease – The RESISTA-PD Trial

Becker, A., Schmartz, G. P., Gröger, L., Grammes, N., Galata, V., Philippeit, H., Weiland, J., Ludwig, N., Meese, E., Tierling, S., et al. (2021) · doi:10.1101/2021.02.07.21251098 · Cited by 102 · see citing works

Review of the effects of sodium butyrate on obesity, inflammatory bowel disease, pregnancy and colorectal cancer

Flegiel, E., Piotrowska, M., Ptasznik, M., Baran, A., Lenart, J., Podrażka, M., Mazurek, J., Stachowicz, H., Bartos, W., & Adamczyk, M. (2024) · Prospects in Pharmaceutical Sciences · doi:10.56782/pps.229 · Cited by 8 · see citing works

Kinetic studies on the metabolism of short-chain fatty acids and glucose by isolated rat colonocytes

Clausen, M. R., & Mortensen, P. B. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90601-7 · Cited by 119 · see citing works

Interactions of acetate, propionate and butyrate in sheep liver mitochondria

Smith, R. M. (1971) · Biochemical Journal · doi:10.1042/bj1240877 · Cited by 24 · see citing works

Quantification of in Vivo Colonic Short Chain Fatty Acid Production from Inulin

Boets, E., Deroover, L., Houben, E., Vermeulen, K., Gomand, S. V., Delcour, J. A., & Verbeke, K. (2015) · Nutrients · doi:10.3390/nu7115440 · Cited by 195 · see citing works

Short chain acyl-CoA synthetases in ovine rumen epithelium

Scaife, J. R., & Tichivangana, J. Z. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90097-1 · Cited by 27 · see citing works

[Determination of volatile fatty acids in the blood plasma of cattle before and after an infusion of propionate and butyrate].

Eulitz-Meder, C., Hartung, J., & Geldermann, H. (1989) · PubMed