Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue
Open accessAbstract
IMPORTANCE: Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of the hosts' immune response to tumor. Evidence also suggests that diet influences intestinal F nucleatum. However, the role of F nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown. OBJECTIVE: To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F nucleatum in tumor tissue. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted using data from the Nurses' Health Study (June 1, 1980, to June 1, 2012) and the Health Professionals Follow-up Study (June 1, 1986, to June 1, 2012) on a total of 121 700 US female nurses and 51 529 US male health professionals aged 30 to 55 years and 40 to 75 years, respectively (both predominantly white individuals), at enrollment. Data analysis was performed from March 15, 2015, to August 10, 2016. EXPOSURES: Prudent and Western diets. MAIN OUTCOMES AND MEASURES: Incidence of colorectal carcinoma subclassified by F nucleatum status in tumor tissue, determined by quantitative polymerase chain reaction. RESULTS: Of the 173 229 individuals considered for the study, 137 217 were included in the analysis, 47 449 were male (34.6%), and mean (SD) baseline age for men was 54.0 (9.8) years and for women, 46.3 (7.2) years. A total of 1019 incident colon and rectal cancer cases with available F nucleatum data were documented over 26 to 32 years of follow-up, encompassing 3 643 562 person-years. The association of prudent diet with colorectal cancer significantly differed by tissue F nucleatum status (P = .01 for heterogeneity); prudent diet score was associated with a lower risk of F nucleatum-positive cancers (P = .003 for trend; multivariable hazard ratio of 0.43; 95% CI, 0.25-0.72, for the highest vs the lowest prudent score quartile) but not with F nucleatum-negative cancers (P = .47 for trend, the corresponding multivariable hazard ratio of 0.95; 95% CI, 0.77-1.17). There was no significant heterogeneity between the subgroups in relation to Western dietary pattern scores. CONCLUSIONS AND RELEVANCE: Prudent diets rich in whole grains and dietary fiber are associated with a lower risk for F nucleatum-positive colorectal cancer but not F nucleatum-negative cancer, supporting a potential role for intestinal microbiota in mediating the association between diet and colorectal neoplasms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A large prospective study found that the association of dietary fiber with reduced colorectal cancer risk had a larger effect on tumors with detectable Fusobacterium nucleatum than those without.
“A large prospective study found that the association of dietary fiber with reduced risk of CRC had a larger effect on tumors with detectable F nucleatum than those without F nucleatum.140”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [140]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Self-citationRichness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works
Rimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116211 · Cited by 2,104 · see citing works
Self-citation<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works
Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · see citing works
Self-citationDietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Willett, W. C. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199754038.001.0001 · Cited by 1,754 · see citing works
Self-citationDiet-induced extinctions in the gut microbiota compound over generations
Sonnenburg, E. D., Smits, S. A., Tikhonov, M., Higginbottom, S. K., Wingreen, N. S., & Sonnenburg, J. L. (2016) · Nature · doi:10.1038/nature16504 · Cited by 1,730 · see citing works
De Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., Serrazanetti, D. I., Di Cagno, R., Ferrocino, I., Lazzi, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309957 · Cited by 1,638 · see citing works
Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490 · see citing works
Self-citationGarrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404 · see citing works
Self-citationAune, D., Chan, D. S. M., Lau, R., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2011) · BMJ · doi:10.1136/bmj.d6617 · Cited by 1,146 · see citing works
<i>Fusobacterium nucleatum</i> in colorectal carcinoma tissue and patient prognosis
Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310101 · Cited by 1,080 · see citing works
Self-citationProspective study of major dietary patterns and risk of coronary heart disease in men
Hu, F. B., Rimm, E. B., Stampfer, M. J., Ascherio, A., Spiegelman, D. L., & Willett, W. C. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.912 · Cited by 1,056 · see citing works
Self-citationFat, fibre and cancer risk in African Americans and rural Africans
O’Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7342 · Cited by 982 · see citing works
Human Gut Microbiome and Risk for Colorectal Cancer
Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt300 · Cited by 947 · see citing works
Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Flemer, B., Lynch, D. B., Brown, J. M. R., Jeffery, I. B., Ryan, F. J., Claesson, M. J., O'Riordain, M., Shanahan, F., & O'Toole, P. W. (2017) · Gut · doi:10.1136/gutjnl-2015-309595 · Cited by 804 · see citing works
Gut mucosal microbiome across stages of colorectal carcinogenesis
Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., et al. (2015) · Nature Communications · doi:10.1038/ncomms9727 · Cited by 701 · see citing works
Microbiota organization is a distinct feature of proximal colorectal cancers
Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700 · see citing works
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
Self-citation<i>Fusobacterium nucleatum</i> and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works
Self-citationInternational Journal of Cancer
Solic, N., Collins, J. E., Richter, A., Holt, S. J., Campbell, I., Alexander, P., & Davies, D. E. (2006) · International Journal of Cancer · doi:10.1002/(issn)1097-0215 · Cited by 665 · see citing works
Ou, J., Carbonero, F., Zoetendal, E. G., DeLany, J. P., Wang, M., Newton, K., Gaskins, H. R., & O’Keefe, S. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.056689 · Cited by 646 · see citing works
Ananthakrishnan, A. N., Khalili, H., Konijeti, G. G., Higuchi, L. M., de Silva, P. S., Korzenik, J. R., Fuchs, C. S., Willett, W. C., Richter, J. M., & Chan, A. T. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.050 · Cited by 633 · see citing works
Self-citationOgino, S., Chan, A. T., Fuchs, C. S., & Giovannucci, E. L. (2010) · Gut · doi:10.1136/gut.2010.217182 · Cited by 521 · see citing works
Self-citationFusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 516 · see citing works
<i>Fusobacterium</i> in Colonic Flora and Molecular Features of Colorectal Carcinoma
Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H.-O., Sugai, T., An, B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1865 · Cited by 465 · see citing works
Co-occurrence of anaerobic bacteria in colorectal carcinomas
Warren, R. L., Freeman, D. J., Pleasance, S., Watson, P., Moore, R. A., Cochrane, K., Allen-Vercoe, E., & Holt, R. A. (2013) · Microbiome · doi:10.1186/2049-2618-1-16 · Cited by 348 · see citing works
Nosho, K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.557 · Cited by 344 · see citing works
Chen, H.-M., Yu, Y.-N., Wang, J.-L., Lin, Y.-W., Kong, X., Yang, C.-Q., Yang, L., Liu, Z.-J., Yuan, Y.-Z., Liu, F., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.046607 · Cited by 321 · see citing works
Ito, M., Kanno, S., Nosho, K., Sukawa, Y., Mitsuhashi, K., Kurihara, H., Igarashi, H., Takahashi, T., Tachibana, M., Takahashi, H., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29488 · Cited by 288 · see citing works
Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location
Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.53 · Cited by 284 · see citing works
Self-citationStatistical methods for studying disease subtype heterogeneity
Wang, M., Spiegelman, D. L., Kuchiba, A., Lochhead, P. J., Kim, S., Chan, A. T., Poole, E. M., Tamimi, R. M., Tworoger, S. S., Giovannucci, E. L., et al. (2015) · Statistics in Medicine · doi:10.1002/sim.6793 · Cited by 269 · see citing works
Self-citationMajor Dietary Patterns and the Risk of Colorectal Cancer in Women
Fung, T. T., Hu, F. B., Fuchs, C. S., Giovannucci, E. L., Hunter, D. J., Stampfer, M. J., Colditz, G. A., & Willett, W. C. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.3.309 · Cited by 266 · see citing works
Self-citationDietary patterns and colorectal cancer
Magalhães, B. M. B. D. S., Peleteiro, B., & Lunet, N. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3283472241 · Cited by 224 · see citing works
Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations
Sinha, R. R., Ahn, J., Sampson, J. N., Shi, J., Yu, G., Xiong, X., Hayes, R. B., & Goedert, J. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152126 · Cited by 220 · see citing works
Dietary patterns and colorectal cancer
Tayyem, R., Bawadi, H. A., Shehadah, I., Agraib, L. M., AbuMweis, S. S., Al‐Jaberi, T., Al-Nusairr, M., Bani-Hani, K. E., & Heath, D. D. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.04.029 · Cited by 209 · see citing works
Prospective Study of Major Dietary Patterns and Colorectal Cancer Risk in Women
Terry, P., Hu, F. B., Hansen, H., & Wolk, A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.12.1143 · Cited by 194 · see citing works
The intestinal microbiome and health
Tuddenham, S., & Sears, C. L. (2015) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000196 · Cited by 180 · see citing works
Ogino, S., Nishihara, R., VanderWeele, T. J., Wang, M., Nishi, A., Lochhead, P. J., Qian, Z. R., Zhang, X., Wu, K., Nan, H., et al. (2016) · Epidemiology · doi:10.1097/ede.0000000000000471 · Cited by 177 · see citing works
Self-citationDietary patterns as identified by factor analysis and colorectal cancer among middle-aged Americans
Flood, A. P., Rastogi, T., Wirfält, E., Mitrou, P. N., Reedy, J., Subar, A. F., Kipnis, V., Mouw, T., Hollenbeck, A. R., Leitzmann, M. F., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.176 · Cited by 159 · see citing works
Hamada, T., Keum, N., Nishihara, R., & Ogino, S. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1272-3 · Cited by 114 · see citing works
Self-citationDietary patterns and subsequent colorectal cancer risk by subsite: A prospective cohort study
Kim, M. K., Sasaki, S., Otani, T., & Tsugane, S. (2005) · International Journal of Cancer · doi:10.1002/ijc.20943 · Cited by 113 · see citing works
Dietary Patterns and Colorectal Adenomas in Japanese Men: The Self-Defense Forces Health Study
Mizoue, T. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi049 · Cited by 76 · see citing works
Dietary patterns and the risk of colorectal adenoma recurrence in a European intervention trial
Cottet, V., Bonithon‐Kopp, C., Kronborg, O., Santos, L. M. V. R., Andreatta, R., Boutron-Ruault, M.-C., & Faivre, J. (2005) · European Journal of Cancer Prevention · doi:10.1097/00008469-200502000-00004 · Cited by 62 · see citing works
Characterization of the gut microbiome in epidemiologic studies: the multiethnic cohort experience
Fu, B. C., Randolph, T. W., Lim, U., Monroe, K. R., Cheng, I. C., Wilkens, L. R., Marchand, L. L., Hullar, M. A. J., & Lampe, J. W. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.02.009 · Cited by 54 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
Keum, N., & Giovannucci, E. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0189-8 · Cited by 2,690 · see citing works
Self-citationFusobacterium nucleatum — symbiont, opportunist and oncobacterium
Brennan, C. A., & Garrett, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0129-6 · Cited by 1,205 · see citing works
Self-citationCirculating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Koupenova, M., Clancy, L., Corkrey, H. A., & Freedman, J. E. (2018) · Circulation Research · doi:10.1161/circresaha.117.310795 · Cited by 998 · see citing works
The Intestinal Microbiota in Colorectal Cancer.
Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777 · see citing works
Human gut microbiota in health and disease: Unveiling the relationship
Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.999001 · Cited by 762 · see citing works
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
Self-citationColorectal Cancer and Nutrition
Thanikachalam, K., & Khan, G. N. (2019) · Nutrients · doi:10.3390/nu11010164 · Cited by 749 · see citing works
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence
Kerr, J., Anderson, C. A. M., & Lippman, S. M. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30411-4 · Cited by 676 · see citing works
Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults
Stoffel, E. M., & Murphy, C. C. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.055 · Cited by 656 · see citing works
Increasing Incidence of Early-Onset Colorectal Cancer
Sinicrope, F. A. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2200869 · Cited by 550 · see citing works
Modulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Screening and prevention of colorectal cancer
Kanth, P., & Inadomi, J. M. (2021) · BMJ · doi:10.1136/bmj.n1855 · Cited by 364 · see citing works
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355 · see citing works
Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention
Song, M., & Chan, A. T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.07.012 · Cited by 355 · see citing works
Self-citationBacteria in cancer initiation, promotion and progression
Tekle, G. E., & Garrett, W. S. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00594-2 · Cited by 349 · see citing works
Self-citationThe Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response
Sánchez‐Alcoholado, L., Ramos‐Molina, B., Otero, A. P., Laborda-Illanes, A., Ordóñez, R., Medina, J. A., Gómez‐Millán, J., & Queipo‐Ortuño, M. I. (2020) · Cancers · doi:10.3390/cancers12061406 · Cited by 338 · see citing works
Dietary patterns and cancer risk
Steck, S. E., & Murphy, E. A. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0227-4 · Cited by 292 · see citing works
Revisit gut microbiota and its impact on human health and disease
Ding, R., Goh, W.-R., Wu, R., Yue, X., Luo, X. G., Khine, W. W. T., Wu, J., & Lee, Y. K. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.12.012 · Cited by 269 · see citing works
<i>Fusobacterium nucleatum</i>and colorectal cancer: A review
Shang, F.-M., & Liu, H.-L. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i3.71 · Cited by 258 · see citing works
Ogino, S., Nowak, J. A., Hamada, T., Milner, D. A., & Nishihara, R. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012818 · Cited by 256 · see citing works
Self-citationTherapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review
Ioniță-Mîndrican, C.-B., Ziani, K., Mititelu, M., Oprea, E., Neacșu, S. M., Moroșan, E., Dumitrescu, D. E., Roșca, A. C., Drăgănescu, D., & Negrei, C. (2022) · Nutrients · doi:10.3390/nu14132641 · Cited by 281 · see citing works
Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer
Koliarakis, I., Messaritakis, I., Νikolouzakis, Τ. Κ., Hamilos, G., Souglakos, J., & Tsiaoussis, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174146 · Cited by 248 · see citing works
Mechanisms of immune activation and regulation: lessons from melanoma
Kalaora, S., Nagler, A., Wargo, J. A., & Samuels, Y. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00442-9 · Cited by 243 · see citing works
Hamada, T., Zhang, X., Mima, K., Bullman, S., Sukawa, Y., Nowak, J. A., Kosumi, K., Masugi, Y., Twombly, T. S., Cao, Y., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0174 · Cited by 232 · see citing works
Self-citationDistinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer
Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11237-6 · Cited by 227 · see citing works
Bishehsari, F., Engen, P. A., Preite, N. Z., Tunçil, Y. E., Naqib, A. D., Shaikh, M. W., Rossi, M., Wilber, S., Green, S. J., Hamaker, B. R., et al. (2018) · Genes · doi:10.3390/genes9020102 · Cited by 216 · see citing works
Future cancer research priorities in the USA: a Lancet Oncology Commission
Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S. N., Bluestone, J. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30698-8 · Cited by 211 · see citing works
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Xiao, Y.-L., Gong, Y., Qi, Y.-J., Shao, Z., & Jiang, Y.-Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01771-x · Cited by 212 · see citing works
High fat diet, gut microbiome and gastrointestinal cancer
Tong, Y., Gao, H., Qi, Q., Liu, X., Li, J., Gao, J., Li, P., Wang, Y., Du, L., & Wang, C. (2021) · Theranostics · doi:10.7150/thno.56157 · Cited by 205 · see citing works
Yamamura, K., Izumi, D., Kandimalla, R., Sonohara, F., Baba, Y., Yoshida, N., Kodera, Y., Baba, H., & Goel, A. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0318 · Cited by 202 · see citing works
Sedentary Behaviors, TV Viewing Time, and Risk of Young-Onset Colorectal Cancer
Nguyen, L. H., Liu, P., Zheng, X., Keum, N., Zong, X., Li, X., Wu, K., Fuchs, C. S., Ogino, S., Ng, K., et al. (2018) · JNCI Cancer Spectrum · doi:10.1093/jncics/pky073 · Cited by 193 · see citing works
Self-citationRadiotherapy and the gut microbiome: facts and fiction
Liu, J., Liu, C., & Yue, J. (2021) · Radiation Oncology · doi:10.1186/s13014-020-01735-9 · Cited by 183 · see citing works
Kim, M., Vogtmann, E., Ahlquist, D. A., Devens, M. E., Kisiel, J. B., Taylor, W. R., White, B. A., Hale, V. L., Sung, J., Chia, N., et al. (2020) · mBio · doi:10.1128/mbio.03186-19 · Cited by 177 · see citing works
The gut microbiome and colorectal cancer: a review of bacterial pathogenesis
Dahmus, J., Kotler, D. L., Kastenberg, D. M., & Kistler, C. A. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.04.07 · Cited by 177 · see citing works
Utilization of the microbiome in personalized medicine
Ratiner, K., Ciocan, D. M., Abdeen, S. K., & Elinav, E. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00998-9 · Cited by 179 · see citing works
Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Ogino, S., Nowak, J. A., Hamada, T., Phipps, A. I., Peters, U., Milner, D. A., Giovannucci, E. L., Nishihara, R., Giannakis, M., Garrett, W. S., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315537 · Cited by 169 · see citing works
Self-citationLuteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
Kang, K. A., Piao, M. J., Ryu, Y. S., Hyun, Y. J., Park, J. E., Shilnikova, K., Zhen, A. X., Kang, H. K., Koh, Y. S., Jeong, Y. J., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4091 · Cited by 168 · see citing works
Role of the oral microbiota in cancer evolution and progression
Sun, J., Tang, Q., Yu, S., Xie, M., Xie, Y., Chen, G., & Chen, L. (2020) · Cancer Medicine · doi:10.1002/cam4.3206 · Cited by 155 · see citing works
Fan, Z., Tang, P., Li, C., Yang, Q., Xu, Y., Su, C., & Li, L. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2145729 · Cited by 150 · see citing works
Exploring the Role of Gut Microbiome in Colon Cancer
Chattopadhyay, I., Dhar, R., Pethusamy, K., Seethy, A. A., Srivastava, T. P., Sah, R., Sharma, J. N., & Karmakar, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03498-9 · Cited by 139 · see citing works
Fusobacterium and Colorectal Cancer
Zhou, Z., Chen, J., Yao, H., & Hu, H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00371 · Cited by 137 · see citing works
Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients
Tsai, P.-C., Lee, T.-H., Kuo, K.-C., Su, F.-Y., Lee, T.-L. M., Marostica, E., Ugai, T., Zhao, M., Lau, M. C., Väyrynen, J. P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37179-4 · Cited by 136 · see citing works
Self-citationPrecancer Atlas to Drive Precision Prevention Trials
Spira, A. E., Yurgelun, M. B., Alexandrov, L. B., Rao, A., Bejar, R., Polyák, K., Giannakis, M., Shilatifard, A., Finn, O. J., Dhodapkar, M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2346 · Cited by 130 · see citing works
Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
Loke, Y. L., Chew, M. T., Ngeow, Y. F., Lim, W. W.-D., & Peh, S. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603086 · Cited by 129 · see citing works
Advances in dietary pattern analysis in nutritional epidemiology
Schulz, C., Oluwagbemigun, K., & Nöthlings, U. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02545-9 · Cited by 128 · see citing works
Dahiya, D., & Nigam, P. S. (2022) · Microorganisms · doi:10.3390/microorganisms10030665 · Cited by 122 · see citing works
Zheng, J., Hoffman, K. L., Chen, J., Shivappa, N., Sood, A., Browman, G. J., Dirba, D. D., Hanash, S., Wei, P., Hébert, J. R., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001853 · Cited by 119 · see citing works
Liu, L., Tabung, F. K., Zhang, X., Nowak, J. A., Qian, Z. R., Hamada, T., Nevo, D., Bullman, S., Mima, K., Kosumi, K., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.04.030 · Cited by 117 · see citing works
Self-citationMontalban‐Arques, A., & Scharl, M. M. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.050 · Cited by 118 · see citing works
Sánchez‐Alcoholado, L., Ordóñez, R., Otero, A. P., Plaza-Andrades, I. J., Laborda-Illanes, A., Medina, J. A., Ramos‐Molina, B., Gómez‐Millán, J., & Queipo‐Ortuño, M. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186782 · Cited by 117 · see citing works
Boehm, E. T., Thon, C., Kupčinskas, J., Steponaitienė, R., Skiecevičienė, J., Canbay, A. E., Malfertheiner, P., & Link, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-73448-8 · Cited by 116 · see citing works
Gomes, S., Oliveira, C. S., Azevedo‐Silva, J., Casanova, M. R., Barreto, J., Pereira, H., Chaves, S. R., Rodrigues, L. R., Casal, M., Côrte‐Real, M., et al. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180530102050 · Cited by 116 · see citing works
Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum
Wang, L., Lo, C., He, X., Hang, D., Wang, M., Wu, K., Chan, A. T., Ogino, S., Giovannucci, E. L., & Song, M. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.03.054 · Cited by 114 · see citing works
Self-citationArima, K., Zhong, R., Ugai, T., Zhao, M. M., Haruki, K., Akimoto, N., Lau, M. C., Okadome, K., Mehta, R. S., Väyrynen, J. P., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.054 · Cited by 117 · see citing works
Self-citationTumorigenic bacteria in colorectal cancer: mechanisms and treatments
Li, S., Liu, J., Zheng, X., Ren, L., Yang, Y., Li, W., Fu, W., Wang, J., & Du, G. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0651 · Cited by 115 · see citing works
The Gut Microbiome and Individual-Specific Responses to Diet
Leshem, A., Segal, E., & Elinav, E. (2020) · mSystems · doi:10.1128/msystems.00665-20 · Cited by 109 · see citing works
Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer
Wang, S.-T., Cui, W., Pan, D., Jiang, M., Chang, B., & Sang, L.-X. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i6.562 · Cited by 110 · see citing works
Park, H. E., Kim, J. H., Cho, N., Lee, H. S., & Kang, G. H. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2171-6 · Cited by 105 · see citing works
Chemoprevention of Colorectal Cancer by Dietary Compounds
Costea, T., Hudiță, A., Ciolac, O.-A., Gălățeanu, B., Ginghină, O., Costache, M., Ganea, C., & Mocanu, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123787 · Cited by 105 · see citing works
Borowsky, J., Haruki, K., Lau, M. C., Costa, A. D., Väyrynen, J. P., Ugai, T., Arima, K., da Silva, A., Felt, K. D., Zhao, M. M., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4009 · Cited by 104 · see citing works
Self-citationHamada, T., Nowak, J. A., Milner, D. A., Song, M., & Ogino, S. (2019) · The Journal of Pathology · doi:10.1002/path.5236 · Cited by 100 · see citing works
Self-citationFiber, Fat, and Colorectal Cancer: New Insight into Modifiable Dietary Risk Factors
Ocvirk, S., Wilson, A. S., Appolonia, C. N., Thomas, T. K., & O’Keefe, S. J. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0725-2 · Cited by 100 · see citing works
The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy
Cogdill, A. P., Gaudreau, P. O., Arora, R., Gopalakrishnan, V., & Wargo, J. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.09.007 · Cited by 98 · see citing works
Lee, D., Han, S., Kang, J., Bae, J. M., Kim, H., Won, J., Jeong, S., Park, K. J., Kang, G. H., & Kim, T. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6681-5 · Cited by 95 · see citing works
Ranjbar, M., Salehi, R., Javanmard, S. H., Rafiee, L., Faraji, H., jafarpor, S., Ferns, G. A., Ghayour‐Mobarhan, M., Manian, M., & Nedaeinia, R. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01886-z · Cited by 95 · see citing works
Inamura, K., Hamada, T., Bullman, S., Ugai, T., Yachida, S., & Ogino, S. (2022) · Gut · doi:10.1136/gutjnl-2022-327209 · Cited by 94 · see citing works
Self-citationDiet and gut microbiome in gastrointestinal disease
Trakman, G., Fehily, S. R., Basnayake, C., Hamilton, A. L., Russell, E., Wilson-O'Brien, A. L., & Kamm, M. A. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15728 · Cited by 90 · see citing works
Microbiome epidemiology and association studies in human health
VanEvery, H., Franzosa, E. A., Nguyen, L. H., & Huttenhower, C. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00529-x · Cited by 85 · see citing works
Self-citationBurns, M. B., Montassier, E., Abrahante, J. E., Priya, S., Niccum, D. E., Khoruts, A., Starr, T. K., Knights, D., & Blekhman, R. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007376 · Cited by 85 · see citing works
Perillo, F., Amoroso, C., Strati, F., Giuffrè, M. R., Díaz‐Basabe, A., Lattanzi, G., & Facciotti, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155389 · Cited by 85 · see citing works
Mucins, gut microbiota, and postbiotics role in colorectal cancer
Pothuraju, R., Chaudhary, S., Rachagani, S., Kaur, S., Roy, H. K., Bouvet, M., & Batra, S. K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1974795 · Cited by 84 · see citing works
Yang, S. Y., Cho, M. S., & Kim, N. K. (2018) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1442217 · Cited by 85 · see citing works
Zhou, J., Yang, Q., Zhao, S., Sun, L., Li, R., Wang, J., Wang, L., & Wang, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102666 · Cited by 84 · see citing works
Ocvirk, S., Wilson, A. S., Posma, J. M., Li, J. V., Koller, K. R., Day, G. M., Flanagan, C. A., Otto, E., Sacco, P. E., Sacco, F. D., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz301 · Cited by 81 · see citing works
Illescas, O., Rodríguez‐Sosa, M., & Gariboldi, M. (2021) · Nutrients · doi:10.3390/nu13072234 · Cited by 80 · see citing works
Emerging Insights into the Esophageal Microbiome
May, M. S., & Abrams, J. A. (2018) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-018-0171-5 · Cited by 77 · see citing works
Yamamoto, H., & Imai, K. (2019) · Seminars in Oncology · doi:10.1053/j.seminoncol.2019.08.003 · Cited by 74 · see citing works
Fusobacterium’s link to colorectal neoplasia sequenced: A systematic review and future insights
Hussan, H., Clinton, S. K., Roberts, K., & Bailey, M. T. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i48.8626 · Cited by 73 · see citing works
Unraveling the Role of the Human Gut Microbiome in Health and Diseases
Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 98 · see citing works
Dahiya, D., & Nigam, P. S. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065748 · Cited by 79 · see citing works
Stem cell division theory of cancer
López‐Lázaro, M. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1062330 · Cited by 70 · see citing works
Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
Zhang, S., Cai, S., & Ma, Y. (2018) · Journal of Cancer · doi:10.7150/jca.24048 · Cited by 73 · see citing works
Zhou, E., & Rifkin, S. B. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2020.10.012 · Cited by 72 · see citing works
Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Klimesova, K., Jiraskova Zakostelska, Z., & Tlaskalova-Hogenova, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00774 · Cited by 67 · see citing works
Gao, Y., Zou, T., Xu, P., Wang, Y., Jiang, Y., Chen, Y., Chen, H., Hong, J., & Fang, J. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100850 · Cited by 67 · see citing works
Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer
Kim, K., Castro, E. J., Shim, H., Advincula, J. V. G., & Kim, Y. W. (2018) · Annals of Coloproctology · doi:10.3393/ac.2018.12.17 · Cited by 68 · see citing works
Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare
Zhang, R., Gao, X., Bai, H., & Ning, K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00538 · Cited by 68 · see citing works
Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics
Ding, C., Tang, W., Fan, X., & Wu, G. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s170626 · Cited by 66 · see citing works
Broadening oncological boundaries: the intratumoral microbiota
Lu, Y.-Q., Qiao, H., Tan, X.-R., & Liu, N. (2024) · Trends in Microbiology · doi:10.1016/j.tim.2024.01.007 · Cited by 66 · see citing works
Increasing Dietary Fiber Intake Is Associated with a Distinct Esophageal Microbiome
Nobel, Y. R., Snider, E. J., Compres, G., Freedberg, D. E., Khiabanian, H., Lightdale, C. J., Toussaint, N. C., & Abrams, J. A. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0067-7 · Cited by 65 · see citing works
Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota
Wisniewski, P. J., Dowden, R. A., & Campbell, S. C. (2019) · Nutrients · doi:10.3390/nu11010117 · Cited by 65 · see citing works
Inamura, K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.006 · Cited by 62 · see citing works
Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Repass, J. F., Reproducibility Project: Cancer Biology, Iorns, E. J., Denis, A., Williams, S. R., Perfito, N., & Errington, T. M. (2018) · eLife · doi:10.7554/elife.25801 · Cited by 63 · see citing works
Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer
Appunni, S., Rubens, M., Ramamoorthy, V., Saxena, A., Tonse, R., McGranaghan, P., Kaiser, A., & Kotecha, R. R. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718389 · Cited by 60 · see citing works
He, X., Wu, K., Zhang, X., Nishihara, R., Cao, Y., Fuchs, C. S., Giovannucci, E. L., Ogino, S., Chan, A. T., & Song, M. (2019) · International Journal of Cancer · doi:10.1002/ijc.32382 · Cited by 60 · see citing works
Self-citationRoles of microbiota in response to cancer immunotherapy
Inamura, K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.12.026 · Cited by 60 · see citing works
Factors Affecting Gut Microbiome in Daily Diet
Su, Q., & Liu, Q. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.644138 · Cited by 60 · see citing works
Pignatelli, P., Iezzi, L., Pennese, M., Raimondi, P., Cichella, A., Bondi, D., Grande, R., Cotellese, R., Bartolomeo, N. D., Innocenti, P., et al. (2021) · Cancers · doi:10.3390/cancers13051032 · Cited by 58 · see citing works
Borozan, I., Zaidi, S. H., Harrison, T. A., Phipps, A. I., Zheng, J., Lee, S., Trinh, Q. M., Steinfelder, R. S., Adams, J., Banbury, B. L., et al. (2022) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0463 · Cited by 57 · see citing works
Self-citationUchino, Y., Goto, Y., Konishi, Y., Tanabe, K., Toda, H., Wada, M., Kita, Y., Beppu, M., Mori, S., Hijioka, H., et al. (2021) · Cancers · doi:10.3390/cancers13133332 · Cited by 57 · see citing works
- Authors
- Mehta, R. S., Nishihara, R., Cao, Y., Song, M., Mima, K., Qian, Z. R., Nowak, J. A., Kosumi, K., Hamada, T., Masugi, Y., Bullman, S., Drew, D. A., Kostic, A. D., Fung, T. T., Garrett, W. S., Huttenhower, C., Wu, K., Meyerhardt, J. A., Zhang, X., Willett, W. C., Giovannucci, E. L., Fuchs, C. S., Chan, A. T., & Ogino, S.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Simmons University (US)
- Corresponding author
- Ogino, Shuji
- ORCID
- Nishihara, Reiko
- Cao, Yin
- Song, Mingyang
- Mima, Kosuke
- Qian, Zhi Rong
- Nowak, Jonathan A.
- Kosumi, Keisuke
- Hamada, Tsuyoshi
- Masugi, Yohei
- Bullman, Susan
- Drew, David A.
- Kostic, Aleksandar D.
- Fung, Teresa T.
- Garrett, Wendy S.
- Huttenhower, Curtis
- Wu, Kana
- Meyerhardt, Jeffrey A.
- Zhang, Xuehong
- Willett, Walter C.
- Giovannucci, Edward L.
- Fuchs, Charles S.
- Chan, Andrew T.
- Ogino, Shuji
- Venue
- JAMA Oncology
- Publisher
- American Medical Association (AMA)
- Published
- 2017-07-01
- Volume
- 3
- Issue
- 7
- Pages
- 921
- ISSN
- 2374-2437 (ISSN-L)
- PMC
- PMC5502000
- OpenAlex
- W2584619074
- Cited by
- 325
- References
- 51
- Citations by year
- 2026: 20 · 2025: 34 · 2024: 28 · 2023: 28 · 2022: 43 · 2021: 44 · 2020: 39 · 2019: 33 · 2018: 42 · 2017: 12 · 2016: 1 · 2015: 1
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Oncology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Entertainment Industry Foundation
- Gary Bennett Family Fund
- National Institutes of Health (CA-167552, CA 87969, CA55075, UL1TR001863)
- National Cancer Institute (P50CA127003, K07CA188126, R01CA202704, R01CA151993, R01CA118553, R01CA137178, R35CA197735, P01CA087969, R01CA169141, P01CA055075, UM1CA186107, UM1CA167552, K07CA190673, R01CA154426)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK098311, P30DK036836, P30DK043351)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Fusobacterium nucleatum, colorectal cancer, prudent diet, Western diet, dietary habits, colorectal cancer subtypes, tumor tissue, whole grains, dietary fiber, red and processed meat, colorectal carcinogenesis, antitumor immunity, Nurses' Health Study, Health Professionals Follow-up Study, colon cancer, rectal cancer, cancer risk factors, gut microbiota
- MeSH terms
- Whole Grains, Gastrointestinal Microbiome, Diet, Healthy, Adult, Aged, Carcinoma, Diet, Dietary Fiber, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, United States, Viral Proteins, Colorectal Neoplasms, Cohort Studies, Incidence, Proportional Hazards Models, Fusobacterium nucleatum, Diet, Western
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
