Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan
Open accessAbstract
Helicobacter pylori is recognised as a main risk factor for gastric cancer. However, approximately half of the patients with gastritis are negative for H. pylori infection, and the abundance of H. pylori decreases in patients with cancer. In the current study, we profiled gastric epithelium-associated bacterial species in patients with gastritis, intestinal metaplasia, and gastric cancer to identify additional potential pathogenic bacteria. The overall composition of the microbiota was similar between the patients with gastritis and those with intestinal metaplasia. H. pylori was present in half of the non-cancer group, and the dominant bacterial species in the H. pylori-negative patients were Burkholderia, Enterobacter, and Leclercia. The abundance of those bacteria was similar between the cancer and non-cancer groups, whereas the frequency and abundance of H. pylori were significantly lower in the cancer group. Instead, Clostridium, Fusobacterium, and Lactobacillus species were frequently abundant in patients with gastric cancer, demonstrating a gastric cancer-specific bacterial signature. A receiver operating characteristic curve analysis showed that Clostridium colicanis and Fusobacterium nucleatum exhibited a diagnostic ability for gastric cancer. Our findings indicate that the gastric microenvironment is frequently colonised by Clostridium and Fusobacterium in patients with gastric cancer.
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Fusobacterium spp. is important in development and progression of gastrointestinal tumors.
“Fusobacterium spp. is important in the development and progression of gastrointestinal tumors1,19,34,35”
From RETRACTED ARTICLE: Microbiome analyses of blood and tissues suggest cancer diagnostic approach (2020) · cites this paper as [35]
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- Authors
- Hsieh, Y.-Y., Tung, S.-Y., Pan, H.-Y., Yen, C.-W., Xu, H.-W., Lin, Y.-J., Deng, Y.-F., Hsu, W.-T., Wu, C.-S., & Li, C.
- Affiliations
- Chang Gung University (TW)
- National Chiayi University (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
- National Chung Cheng University (TW)
- Corresponding author
- Wu, Cheng-Shyong
- Li, Chin
- Venue
- Scientific Reports
- Published
- 2018-01-09
- Volume
- 8
- Issue
- 1
- Pages
- 158-158
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5760541
- OpenAlex
- W2781688166
- Cited by
- 269
- References
- 50
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 39 · 2023: 36 · 2022: 34 · 2021: 45 · 2020: 31 · 2019: 21 · 2018: 10
- FWCI
- 27.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Chang Gung Medical Foundation
- Chiayi Chang Gung Memorial Hospital (CORPG6D0063, CORPG6D0071, CORPG6D0012, CORPG6D0011, CORPG6D0061, CORPG6D0073, CORPG6D0072, CORPG6D0013, CORPG6D0062)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gastric cancer, gastric microbiota, Clostridium, Fusobacterium, Helicobacter pylori, intestinal metaplasia, gastritis, Fusobacterium nucleatum, cancer diagnosis, Lactobacillus, Burkholderia, Enterobacter, Leclercia
- MeSH terms
- Adult, Aged, Clostridium, Clostridium Infections, Female, Fusobacterium, Fusobacterium Infections, Gastric Mucosa, Humans, Male, Metaplasia, Middle Aged, Neoplasm Staging, RNA, Ribosomal, 16S, Stomach Neoplasms, Taiwan, Young Adult
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