Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence
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Fusobacterium nucleatum is a Gram-negative anaerobic oral commensal associated with periodontal disease. F. nucleatum has been implicated in a wide spectrum of systemic diseases, including oral, gastro-intestinal, rheumatologic, and vascular pathologies. As pregnancy risk has been linked to periodontal disease, there has also been significant research into the effects of periodontal disease on adverse pregnancy outcomes. This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes.
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Studies investigating the placental microbiome to understand its role in preterm pregnancies have identified bacteria associated with periodontal disease, suggesting a relationship between the oral and placental microbiomes.
“Studies investigating the placental microbiome to understand its role in preterm pregnancies have identified bacteria associated with periodontal disease, suggesting a relationship between the oral and placental microbiomes.113, 114, 115, 116”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
Pathogenic bacteria from the oral cavity found at various sites within the uterus are associated with adverse pregnancy outcomes, such as preterm delivery and preeclampsia.
“Pathogenic bacteria from the oral cavity found at various sites within the uterus are associated with adverse pregnancy outcomes, such as preterm delivery and preeclampsia.113, 114, 115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
Bacteria of oral origin, namely Fusobacterium nucleatum, were identified in samples of amniotic fluid and cord blood from women with pregnancy complications, suggesting oral translocation via hematogenous mechanisms.
“Similarly, bacteria of oral origin, namely Fusobacterium nucleatum, were identified in samples of amniotic fluid and cord blood from women with pregnancy complications, suggesting oral translocation via hematogenous mechanisms.115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
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“nucleatum) is one of the most frequently detected pathogens and has attracted increasing attention in recent years as an opportunistic pathogen in many systematic diseases, such as colorectal cancer,(5) cardiovascular diseases,(6) Alzheimer’s disease,(7) and adverse pregnancy outcomes.(8) F.”
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“The FadA adhesins of F. nucleatum binds to the cadherins on the maternal endothelium and invade the cell to cell junction of the maternal and foetal cells (Han et al. 2004; Liu et al. 2007; Xu et al. 2007; Fardini et al. 2011; Vander Haar et al. 2018).”
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“nucleatum to the fetal-placental unit, where multiple studies support a role for this bacterium in preterm birth (82, 83).”
BackgroundPlacental microbial–metabolite profiles and inflammatory mechanisms associated with preterm birth
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Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum
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“It can translocate from the oral cavity to extraoral sites, including the placenta, where it may trigger inflammation and adverse pregnancy outcomes such as preterm labor, fetal growth restriction, and miscarriage [16].”
Fusobacterium nucleatum : a novel immune modulator in breast cancer?
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“FadA may also bind to the vascular endothelial cadherins (VE-cadherin) increasing endothelial cells permeability allowing bacteria to penetrate through endothelium, overcome blood-brain and placental barrier and colonize the distant parts of the human body [81].”
BackgroundPeriodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
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“…pias et al. 2022 , Rashidi et al. 2023 ), undernutrition (Vonaesch et al. 2018 , 2022 , Chen et al. 2020 , Col-lard et al. 2022 ), preterm birth (Van der Haar et al. 2018 , Yin et al. 2021 ), neurological diseases (Nicholson and Landry 2022 ), liver diseases (Joossens 2021 ), lung diseases…”
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“nucleatum acts as an opportunistic pathogen in multiple inflammatory diseases, including periodontitis (5), inflammatory bowel disease (6), liver abscesses (7), rheumatoid arthritis (8), and chorioamnionitis (9).”
BackgroundInsight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease
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“In early pregnancy, periodontal pathogens could reach the placenta by specific routes and colonize the placenta, which may lead to adverse pregnancy outcomes such as premature delivery, amnionitis, and stillbirth [20].”
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“) nucleatum were linked to adverse pregnancy outcomes [7, 17, 18].”
BackgroundComprehensive human amniotic fluid metagenomics supports the sterile womb hypothesis
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Fusobacterium nucleatum dissemination by neutrophils
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Targeted elimination of Fusobacterium nucleatum alleviates periodontitis
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Addressing controversy in Fusobacterium nomenclature: what exactly does “ F. nucleatum ” refer to?
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“40,41 Fusobacterium and Streptococcus thermophiles species were also associated with chorioamnionitis in preterm labor.”
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Fusobacterium nucleatum and non-coding RNAs: orchestrating oncogenic pathways in colorectal cancer
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“Under certain conditions, Fn can translocate across mucosal barriers to distant tissues and has been associated with several systemic conditions, including atherosclerosis, colorectal cancer, and adverse pregnancy outcomes [5–7].”
HicA Toxin-Based Counterselection Marker for Allelic Exchange Mutations in Fusobacterium nucleatum
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Low Abundance Fusobacterium Nucleatum Supports Early Pregnancy Development – An In Vitro Study
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“Also, F. nucleatum can colonizethe placenta and cause preterm birth, intra-amniotic infection, stillbirth, neonatal sepsis, and hypertensive disorders of pregnancy 1,8,9 .”
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Fusobacterium nucleatum and Prevotella in women with periodontitis and preterm birth
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“Although the exact mechanisms that clearly explain the participation of periodontitis in the adverse effects of pregnancy have not yet been established, some theories try to seek an explanation through two mechanisms: by the action of periodontal pathogens or by the effect of inflammatory mediators, such as interleuki…”
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“…to treat infections associated with this pathogen, particularly in the context of colorectal cancer, periodontal disease and even reproductive diseases such as pre-term birth and endometriosis (Han et al. 2004; Vander Haar et al. 2018; Sun et al. 2019; Chen et al. 2022; Muraoka et al. 2023).”
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Fulminant Sepsis and Perinatal Death at 23 Weeks Due to Fusobacterium nucleatum
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“Additionally, FadA plays a crucial role in the colonization of Fpo ATCC 12,230 in the mouse placenta [5] and was also shown to be a key driver of host cell signaling in this strain.”
The Oral Microbiome Throughout Pregnancy
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“nucleatum infection is associated with oral infections such as periodontal disease and obstetric infections that are harmful to pregnancy [2,4].”
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“nucleatum plays an essential role in extra-oral diseases like preterm 48 birth (11, 12) and colorectal cancer (13-16).”
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“have been repeatedly associated with preterm birth [11].”
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A New Method for Gene Deletion to Investigate Cell Wall Biogenesis in Fusobacterium nucleatum
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- Authors
- Vander Haar, E. L., So, J., Gyamfi-Bannerman, C., & Han, Y. W.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Han, Yiping W.
- ORCID
- Han, Yiping W.
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 50
- Pages
- 55-59
- ISSN
- 1075-9964 (ISSN-L)
- PMC
- PMC6750227
- OpenAlex
- W2791709251
- Cited by
- 155
- References
- 60
- Citations by year
- 2026: 23 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 4 · 2018: 1 · 2016: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Anaerobe (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Funders
- NIH (DE014924, DE023332, CA192111)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- Fusobacterium nucleatum, adverse pregnancy outcomes, periodontal disease, oral commensals, oral microbiota, systemic inflammation, pregnancy complications, periodontitis
- MeSH terms
- Animals, Female, Fusobacterium Infections, Humans, Mouth Mucosa, Periodontal Diseases, Pregnancy, Pregnancy Complications, Pregnancy Complications, Infectious, Pregnancy Outcome, Virulence, Fusobacterium nucleatum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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