The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell Repertoire
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Immune function in the elderly is associated with a number of phenotypic and functional abnormalities, and this phenomenon of immune senescence is associated with increased susceptibility to infection. The immune response to pathogens frequently declines with age, but the CD8 + T-cell response to cytomegalovirus (CMV) is unusual, as it demonstrates a significant expansion over time. Here we have documented the CD4 + T-cell immune response to CMV in healthy donors of different ages. The magnitude of the CMV-specific CD4 + T-cell immune response increases from a mean of 2.2% of the CD4 + T-cell pool in donors below 50 years of age to 4.7% in donors aged over 65 years. In addition, CMV-specific CD4 + T cells in elderly donors demonstrate decreased production of interleukin-2 and less dependence on costimulation. CMV seropositivity is associated with marked changes in the phenotype of the overall CD4 + T-cell repertoire in healthy aged donors, including an increase in CD57 + expression and a decrease in CD28 and CD27 expression, a phenotypic profile characteristic of immune senescence. This memory inflation of CMV-specific CD4 + T cells contributes to evidence that CMV infection may be damaging to immune function in elderly individuals.
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Frequencies of CMV-specific and, to a lesser extent, EBV-specific CD8+ T cells tend to increase with age, protecting older individuals from CMV- and EBV-associated morbidities.
“frequencies of CMV-specific and to a lesser extent EBV-specific CD8+ T cells tend to increase, successfully protecting aging individuals from CMV- and EBV-associated morbidities”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Pourgheysari et al., 2007
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The immune system in the aging human
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T cells in arteritis and atherosclerosis
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Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus
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Regulatory function of cytomegalovirus-specific CD4+CD27−CD28− T cells
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Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells
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The interplay between immune maturation, age, chronic viral infection and environment
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Cytomegalovirus drives Vδ2neg γδ T cell inflation in many healthy virus carriers with increasing age
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Self-citationAlloreactivity Across HLA Barriers Is Mediated by Both Naïve and Antigen-Experienced T Cells
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- Authors
- Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H.
- Affiliations
- University of Birmingham (GB)
- University of Liverpool (GB)
- Department of Applied Gerontology, Selly Oak, Birmingham, United Kingdom
- Corresponding author
- Moss, Paul A. H.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-07-15
- Volume
- 81
- Issue
- 14
- Pages
- 7759-7765
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC1933343
- OpenAlex
- W2115516753
- Cited by
- 214
- References
- 29
- Citations by year
- 2025: 11 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 13
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- cytomegalovirus, CD4+ T cells, immunosenescence, aging, CMV-specific T-cell responses, interleukin-2, CD57, CD28, CD27, memory inflation, CMV seropositivity, elderly donors
- MeSH terms
- Aged, Aging, Cytomegalovirus, Humans, Interferon-gamma, Interleukin-2, CD4-Positive T-Lymphocytes
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