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Cited by 124Gut microbiota and healthGastrointestinal motility and disordersAmyotrophic Lateral Sclerosis Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

The human gut microbiota in people with amyotrophic lateral sclerosis

Open access
Nicholson, Katharine, Bjornevik, Kjetil, Abu-Ali, Galeb, Chan, James, Cortese, Marianna, Dedi, Brixhilda, Jeon, Maryangel, Xavier, Ramnik, Huttenhower, Curtis, Ascherio, Alberto, Berry, James D.·2021·Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
DOI 10.1080/21678421.2020.1828475
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Abstract

Objective To characterize the gut microbiota in people with amyotrophic lateral sclerosis (ALS) relative to controls and to test the hypothesis that butyrate-producing bacteria are less abundant in the gastrointestinal tracts of people with ALS (PALS). Methods: We conducted a case–control study at Massachusetts General Hospital to compare the gut microbiota in people with ALS to that in controls. Metagenomic shotgun sequencing was performed on DNA extracted from stool samples of 66 people with ALS (PALS), 61 healthy controls (HC), and 12 neurodegenerative controls (NDC). Taxonomic metagenomic profiles were analyzed for shifts in the microbial community structure between the comparator groups using per-feature univariate and multivariate association tests. Results: The relative abundance of the dominant butyrate-producing bacteria Eubacterium rectale and Roseburia intestinalis was significantly lower in ALS patients compared to HC. Adjustment for age, sex, and constipation did not materially change the results. The total abundance of 8 dominant species capable of producing butyrate was also significantly lower in ALS compared to HC (p < 0.001). Conclusions: The levels of several butyrate-producing bacteria, which are important for gut integrity and regulation of inflammation, were lower in people with ALS compared to controls. These findings lend support to the inference that the gut microbiota could be a risk factor for ALS. Further investigations are warranted, preferably earlier in the disease with corresponding dietary collection and a longitudinal design.

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Crossref · 10.1080/21678421.2020.1828475

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Metadata

Authors
Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., & Berry, J. D.
Affiliations
  • Massachusetts General Hospital (US)
  • Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Broad Institute (US)
  • Harvard University (US)
  • Brigham and Women's Hospital (US)
ORCID
Venue
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Publisher
Informa UK Limited
Published
2020-11-02
Volume
22
Issue
3-4
Pages
186-194
ISSN
  • 2167-8421 (ISSN-L)
  • 2167-9223
DOI
10.1080/21678421.2020.1828475
OpenAlex
W3096334056
Cited by
123
References
40
Citations by year
2026: 19 · 2025: 23 · 2024: 28 · 2023: 20 · 2022: 24 · 2021: 8 · 2020: 1
FWCI
4.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • ALS Finding a Cure
  • Winthrop Family Fund in ALS Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
amyotrophic lateral sclerosis, gut microbiota, butyrate-producing bacteria, Eubacterium rectale, Roseburia intestinalis, microbial community structure, intestinal barrier integrity, inflammation, neurodegenerative diseases, risk factors, constipation
MeSH terms
Clostridiales, Eubacteriales, Gastrointestinal Microbiome, Amyotrophic Lateral Sclerosis, Humans, Case-Control Studies

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