Cited by 124Gut microbiota and healthGastrointestinal motility and disordersAmyotrophic Lateral Sclerosis Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

The human gut microbiota in people with amyotrophic lateral sclerosis

Open access

Nicholson, Katharine, Bjornevik, Kjetil, Abu-Ali, Galeb, Chan, James, Cortese, Marianna, Dedi, Brixhilda, Jeon, Maryangel, Xavier, Ramnik, Huttenhower, Curtis, Ascherio, Alberto, Berry, James D.·2021·Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

DOI 10.1080/21678421.2020.1828475

Open this paper in CoChat — free account

Abstract

Objective To characterize the gut microbiota in people with amyotrophic lateral sclerosis (ALS) relative to controls and to test the hypothesis that butyrate-producing bacteria are less abundant in the gastrointestinal tracts of people with ALS (PALS). Methods: We conducted a case–control study at Massachusetts General Hospital to compare the gut microbiota in people with ALS to that in controls. Metagenomic shotgun sequencing was performed on DNA extracted from stool samples of 66 people with ALS (PALS), 61 healthy controls (HC), and 12 neurodegenerative controls (NDC). Taxonomic metagenomic profiles were analyzed for shifts in the microbial community structure between the comparator groups using per-feature univariate and multivariate association tests. Results: The relative abundance of the dominant butyrate-producing bacteria Eubacterium rectale and Roseburia intestinalis was significantly lower in ALS patients compared to HC. Adjustment for age, sex, and constipation did not materially change the results. The total abundance of 8 dominant species capable of producing butyrate was also significantly lower in ALS compared to HC (p < 0.001). Conclusions: The levels of several butyrate-producing bacteria, which are important for gut integrity and regulation of inflammation, were lower in people with ALS compared to controls. These findings lend support to the inference that the gut microbiota could be a risk factor for ALS. Further investigations are warranted, preferably earlier in the disease with corresponding dietary collection and a longitudinal design.

Integrity signals

Registry

Crossref · 10.1080/21678421.2020.1828475

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Regression shrinkage and selection via the lasso
Tibshirani, R. (1996) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1996.tb02080.x · Cited by 51,482
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,942
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,770
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
Self-citation
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,144
Formation of propionate and butyrate by the human colonic microbiota
Louis, P., & Flint, H. J. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13589 · Cited by 3,028

Show all 40 references

Sorted by citations

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases
Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2076064 · Cited by 156
The Relationship Between the Gut Microbiome and Neurodegenerative Diseases
Zhu, X., Li, B., Lou, P., Dai, T., Chen, Y., Zhuge, A., Yuan, Y., & Li, L. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00730-8 · Cited by 137
Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127
Gut Microbiota Interaction with the Central Nervous System throughout Life
Ojeda, J., Ávila, A., & Vidal, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061299 · Cited by 112
The amyotrophic lateral sclerosis exposome: recent advances and future directions
Goutman, S. A., Savelieff, M. G., Jang, D., Hur, J., & Feldman, E. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00867-2 · Cited by 110
Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers
Hajjo, R., Sabbah, D. A., & Bawab, A. Q. A. (2022) · Diagnostics · doi:10.3390/diagnostics12071742 · Cited by 105
Brain modulation by the gut microbiota: From disease to therapy
Mitra, S., Dash, R., Nishan, A. A., Habiba, S. U., & Moon, I. S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2022.12.001 · Cited by 91
Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis
Sever, B., Ciftci, H. I., DeMi̇rci̇, H., Sever, H., Ocak, F., Yuluğ, B., Tateishi, H., Tateishi, T., Otsuka, M., Fujita, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052400 · Cited by 80
Gut microbiome differences between amyotrophic lateral sclerosis patients and spouse controls
Hertzberg, V., Singh, H., Fournier, C. N., Moustafa, A., Polak, M. A., Kuelbs, C., Torralba, M., Tansey, M. G., Nelson, K. E., & Glass, J. D. (2021) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2021.1904994 · Cited by 81
Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions
Sakowski, S. A., Koubek, E. J., Chen, K. S., Goutman, S. A., & Feldman, E. L. (2024) · Annals of Neurology · doi:10.1002/ana.26897 · Cited by 83
Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 75
New hope for Parkinson’s disease treatment: Targeting gut microbiota
Fan, H., Sheng, S., & Zhang, F. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13916 · Cited by 66
Interactions between gut microbiota and skeletal muscle
Gizard, F., Fernandez, A., & Vadder, F. D. (2020) · Nutrition and Metabolic Insights · doi:10.1177/1178638820980490 · Cited by 70
The Gut Microbiota-Immunity Axis in ALS: A Role in Deciphering Disease Heterogeneity?
Niccolai, E., Pilato, V. D., Nannini, G., Baldi, S., Russo, E., Zucchi, E., Martinelli, I., Menicatti, M., Bartolucci, G., Mandrioli, J., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9070753 · Cited by 66
Gut microbiota in dementia with Lewy bodies
Nishiwaki, H., Ueyama, J., Kashihara, K., Ito, M., Hamaguchi, T., Maeda, T., Tsuboi, Y., Katsuno, M., Hirayama, M., & Ohno, K. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00428-2 · Cited by 59
The Gut Microbiome–Brain Crosstalk in Neurodegenerative Diseases
Ghezzi, L., Cantoni, C., Rotondo, E., & Galimberti, D. (2022) · Biomedicines · doi:10.3390/biomedicines10071486 · Cited by 61
Assessment of the safety and probiotic properties of Roseburia intestinalis: A potential “Next Generation Probiotic”
Zhang, C., Ma, K., Nie, K., Deng, M., Luo, W., Wu, X., Huang, Y., & Wang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.973046 · Cited by 65
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact
Marchi, F. D., Munitić, I., Amedei, A., Berry, J. D., Feldman, E. L., Aronica, E., Nardo, G., Weehaeghe, D. V., Niccolai, E., Prtenjača, N., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.027 · Cited by 52
Self-citation
The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
Cox, L. M., Calcagno, N., Gauthier, C., Madore, C., Butovsky, O., & Weiner, H. L. (2022) · Microbiome · doi:10.1186/s40168-022-01232-z · Cited by 53
Effects of gut microbiota on neurodegenerative diseases
Khatoon, S., Kalam, N., Rashid, S., & Bano, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1145241 · Cited by 55
Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing bacteria
Ambat, A., Antony, L., Maji, A., Ghimire, S., Mattiello, S. P., Kashyap, P., More, S., Sebastian, V., & Scaria, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2382324 · Cited by 54
Deciphering the gut microbiome in neurodegenerative diseases and metagenomic approaches for characterization of gut microbes
Singh, N., Singh, V., Nand, S., Mishra, V., Vamanu, E., & Singh, M. P. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113958 · Cited by 54
The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects
Li, R., Miao, Z., Liu, Y., Chen, X., Wang, H., Su, J., & Chen, J. (2024) · Advanced Science · doi:10.1002/advs.202307971 · Cited by 54
A review of the preclinical and clinical studies on the role of the gut microbiome in aging and neurodegenerative diseases and its modulation
Hashim, H. M., & Makpol, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1007166 · Cited by 47
Gut microbiome and amyotrophic lateral sclerosis: a systematic review of current evidence
Sun, J., Huang, T., Debelius, J. W., & Fang, F. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13336 · Cited by 43
New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis
Theunissen, F., West, P. K., Brennan, S. E., Petrović, B., Hooshmand, K., Akkari, P. A., Keon, M., & Guennewig, B. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00272-z · Cited by 43
Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis
Guo, K., Figueroa‐Romero, C., Noureldein, M. H., Murdock, B. J., Savelieff, M. G., Hur, J., Goutman, S. A., & Feldman, E. L. (2023) · Brain · doi:10.1093/brain/awad306 · Cited by 46
Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis
Yan, J., Chen, H., Zhang, Y., Peng, L., Wang, Z.-K., Lan, X., Yu, S., & Yang, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2353396 · Cited by 40
The Crosstalk between Microbiome and Mitochondrial Homeostasis in Neurodegeneration
Borbolis, F., Mytilinaiou, E., & Palikaras, K. (2023) · Cells · doi:10.3390/cells12030429 · Cited by 42
Butyrate as a potential therapeutic agent for neurodegenerative disorders
Chakraborty, P., Gamage, H. K. A. H., & Laird, A. S. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105745 · Cited by 44
Microbial signatures and therapeutic strategies in neurodegenerative diseases
Rob, M., Yousef, M., Lakshmanan, A. P., Mahboob, A., Terranegra, A., & Châari, A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117905 · Cited by 43
Brain-Gut-Microbiota Axis in Amyotrophic Lateral Sclerosis: A Historical Overview and Future Directions
Chen, S., Cai, X., Lao, L., Wang, Y., Su, H., & Sun, H. (2024) · Aging and Disease · doi:10.14336/ad.2023.0524 · Cited by 40
Gut microbiota in muscular atrophy development, progression, and treatment: New therapeutic targets and opportunities
Chen, S., Zhang, P., Duan, H., Wang, J., Qiu, Y., Cui, Z., Yin, Y., Wan, D., & Xie, L. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100479 · Cited by 40
Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A systematic review
Chatterjee, A., Kumar, S., Sarkar, S. R., Halder, R., Kumari, R., Banerjee, S., & Sarkar, B. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109622 · Cited by 36
A role for microglia in mediating the microbiota–gut–brain axis
Keane, L., Clarke, G. A., & Cryan, J. F. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01188-9 · Cited by 43
Gut microbiota immune cross-talk in amyotrophic lateral sclerosis
Kaul, M., Mukherjee, D., Weiner, H. L., & Cox, L. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00469 · Cited by 36
Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis
Du, H., Huo, Z., Chen, Y., Zhao, Z., Meng, F., Wang, X., Liu, S., Zhang, H., Zhou, F., Liu, J., et al. (2023) · Cells · doi:10.3390/cells12060971 · Cited by 36
The Role of the Gut Microbiota in Neurodegenerative Diseases
Mani, A. P., Balasubramanian, B., Mali, L. A., Joseph, K. S., Meyyazhagan, A., Pappuswamy, M., & Joseph, B. V. (2024) · Microbiology Research · doi:10.3390/microbiolres15020033 · Cited by 37
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives
Eddin, A. N., Alfuwais, M., Eddin, R. N., AlKattan, K. M., & Yaqinuddin, A. (2024) · Nutrients · doi:10.3390/nu16050590 · Cited by 32
Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: A multi-omics study
Gong, Z., Ba, L., Tang, J., Yang, Y., Li, Z., Liu, M., Yang, C., Ding, F., & Zhang, M. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220198 · Cited by 25
Nutritional and Microbiota-Based Approaches in Amyotrophic Lateral Sclerosis: From Prevention to Treatment
Cuffaro, F., Lamminpää, I., Niccolai, E., & Amedei, A. (2024) · Nutrients · doi:10.3390/nu17010102 · Cited by 25
The diagnostic potential and barriers of microbiome based therapeutics
Acharjee, A., Singh, U., Choudhury, S. P., & Gkoutos, G. V. (2022) · Diagnosis · doi:10.1515/dx-2022-0052 · Cited by 23
The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances
Li, S., Zhao, L., Xiao, J., Guo, Y., Fu, R., Zhang, Y., & Xu, S. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04853-6 · Cited by 23
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications
Balakrishnan, R., Kang, S.-I., Lee, J. Y., Rho, Y., Kim, B.-K., & Choi, D. (2024) · Aging and Disease · doi:10.14336/ad.2024.1362 · Cited by 22
Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial
Kim, J. H., Choi, Y., Lee, S.-M., & Oh, M. S. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.215 · Cited by 22
New Insights into the Relationship between Nutrition and Neuroinflammation in Alzheimer's Disease: Preventive and Therapeutic Perspectives
Marchi, F. D., Vignaroli, F., Mazzini, L., Comi, C., & Tondo, G. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230608110201 · Cited by 19
Characteristics of Intestinal Microbiota in Japanese Patients with Mild Cognitive Impairment and a Risk-Estimating Method for the Disorder
Hatayama, K., Ebara, A., Okuma, K., Tokuno, H., Hasuko, K., Masuyama, H., Ashikari, I., & Shirasawa, T. (2023) · Biomedicines · doi:10.3390/biomedicines11071789 · Cited by 21
Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases
Nie, T., Li, Y., Tang, F., Duan, Y., Nepovimová, E., Kuča, K., Wu, Q., & Wei, W. (2024) · Current Neuropharmacology · doi:10.2174/1570159x23666241101093436 · Cited by 20
An Integrative Analysis of Metagenomic and Metabolomic Profiling Reveals Gut Microbiome Dysbiosis and Metabolic Alterations in ALS: Potential Biomarkers and Therapeutic Insights
Gautam, P., Yadav, R., Vishwakarma, R. K., Shekhar, S., Pathak, A., & Singh, C. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00254 · Cited by 18
Gut Microbes Associated with Neurodegenerative Disorders: A Comprehensive Review of the Literature
Koutsokostas, C., Merkouris, E., Goulas, A., Aidinopoulou, K., Sini, N., Dimaras, T., Tsiptsios, D., Mueller, C., Nystazaki, M., & Tsamakis, K. (2024) · Microorganisms · doi:10.3390/microorganisms12081735 · Cited by 18
Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation
Ayala, V., Fontdevila, L., Rico-Rios, S., Povedano, M., Andrés‐Benito, P., Torres, P., Serrano, J. C. E., Pamplona, R., & Portero‐Otín, M. (2025) · Sclerosis · doi:10.3390/sclerosis3010008 · Cited by 15
The role of gut microbiota–mitochondria crosstalk in neurodegeneration: Underlying mechanisms and potential therapies
Ju, T., Zhang, Y., Liu, L., Zhao, X., Li, X., Liu, C., Sun, S., & Wu, L. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01419 · Cited by 16
Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut–Brain Axis
Sharma, V. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08870-0 · Cited by 14
The microbiota-inflammasome-brain axis as a pathogenic mediator of neurodegenerative disorders
Sarkar, S. K., Gubert, C., & Hannan, A. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106276 · Cited by 15
Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis
Walker, A. C., Bhargava, R., Dove, A. S., Brust, A. S., Owji, A. A., & Czyż, D. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094807 · Cited by 15
Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis
Calvo, A. C., Valledor-Martín, I., Moreno‐Martínez, L., Toivonen, J. M., & Osta, R. (2022) · Genes · doi:10.3390/genes13050865 · Cited by 15
Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration
Mitra, S., Munni, Y. A., Dash, R., Sadhu, T., Barua, L., Islam, M. A., Chowdhury, D., Bhattacharjee, D., Mazumder, K., & Moon, I. S. (2023) · Life · doi:10.3390/life13040957 · Cited by 13
Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice
Gamage, H. K. A. H., Robinson, K. J., Luu, L., Paulsen, I. T., & Laird, A. S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106051 · Cited by 13
The Microbiome–Neurodegeneration Interface: Mechanisms, Evidence, and Future Directions
Böckels, L., Alexa, D., Antal, D. C., Gațcan, C., Alecu, C., Kacani, K., Cretu, R. A., Piseru, E.-A., Bîlcu, R. V., & Cuciureanu, D. I. (2026) · Cells · doi:10.3390/cells15020135 · Cited by 13
ALSUntangled #64: butyrates
Sun, Y., Bedlack, R., Armon, C., Beauchamp, M. T., Bertorini, T. E., Bowser, R. P., Bromberg, M. B., Caress, J. B., Carter, G. L., Crayle, J. I., et al. (2022) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2022.2045323 · Cited by 11
Alterations in nasal microbiota of patients with amyotrophic lateral sclerosis
Liu, K., Guo, Q., Ding, Y., Luo, L., Huang, J., & Zhang, Q. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002701 · Cited by 11
Impact of Donepezil Supplementation on Alzheimer’s Disease-like Pathology and Gut Microbiome in APP/PS1 Mice
Li, Y., Wu, M., Kong, M., Sui, S., Wang, Q., He, Y., & Gu, J. (2023) · Microorganisms · doi:10.3390/microorganisms11092306 · Cited by 12
Ageing, proteostasis, and the gut: Insights into neurological health and disease
Akbar, M., Toppo, P., & Nazir, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102504 · Cited by 13
Precision neurology
Small, S. L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102632 · Cited by 10
Re-Analyses of Samples From Amyotrophic Lateral Sclerosis Patients and Controls Identify Many Novel Small RNAs With Diagnostic And Prognostic Potential
Loher, P., Londin, E. R., Ilieva, H. S., Pasinelli, P., & Rigoutsos, I. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04747-2 · Cited by 10
Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onsetPreprint
Waldron, F. M., Langerová, T., Rahmanova, A., Read, F. L., Spence, H., Roberts, K., Macleod, A. D., Pattle, S. B., Hanna, K., & Gregory, J. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.10.648122 · Cited by 10
Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome
Konstanti, P., Martínez, C. G., Muralidharan, J., Vioqué, J., Corella, D., Fitó, M., Vidal, J., Tinahones, F. J., Collado, L. T., Coltell, Ó., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78527-8 · Cited by 11
Microbiota Dysbiosis in Amyotrophic Lateral Sclerosis: A Systematic Review of Human Studies
Gautam, P., Vishwakarma, R. K., Nath, M., Nath, G., & Pathak, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05481-5 · Cited by 9
Anaerobes in specific infectious and noninfectious diseases: new developments
Boyanova, L., Markovska, R. D., Yordanov, D., Gergova, R. T., & Hadzhiyski, P. (2023) · Anaerobe · doi:10.1016/j.anaerobe.2023.102714 · Cited by 8
The relationship between acrylamide and neurodegenerative diseases: gut microbiota as a new intermediate cue
Xu, X., Wei, S., Lin, M., Chen, F., Zhang, X., & Zhu, Y. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2440602 · Cited by 9
Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS)
Трофимов, А. Н., Pavlov, D., Goswami, A., Вячеславовна, Г. А., Chaprov, K., Umriukhin, A., Kalueff, A. V., Deykin, A. V., Lesch, K., Anthony, D. C., et al. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100686 · Cited by 6
Informatics for your Gut: at the Interface of Nutrition, the Microbiome, and Technology
Cooper, K., Clarke, M. A., & Clayton, J. B. (2023) · Yearbook of Medical Informatics · doi:10.1055/s-0043-1768723 · Cited by 6
Roseburia intestinalis Modulates Immune Responses by Inducing M1 Macrophage Polarization
Bircher, A., Katkeviciutė, E., Morsy, Y., Lang, S., Montalban‐Arques, A., & Scharl, M. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115049 · Cited by 6
Dietary modulation of the gut microbiome as a supportive strategy in the treatment of amyotrophic lateral sclerosis – a narrative review
Kiecka, A., & Szczepanik, M. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00800-y · Cited by 5
Microbiome and metabolites impact enteric and central nervous systems in ALS
Walton, E. I., & Sun, J. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2692737 · Cited by 4
Alteration of serum bile acids in amyotrophic lateral sclerosis
Lee, I., Nandakumar, R., & Haeusler, R. A. (2024) · Lipids · doi:10.1002/lipd.12390 · Cited by 4
Gut metabolomic and microbiota analyses in ALS mice reveal specific metabolites despite the absence of significant gut dysbiosis
Veyrat‐Durebex, C., Osman, S., Ojaimi, Y. A., Gosset, P., Dupuy, C., Lefèvre, A., Emond, P., Vourc’h, P., Corcia, P., Méreghetti, L., et al. (2024) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2024.2433578 · Cited by 3
The Emerging Role of the Brain–Gut Axis in Amyotrophic Lateral Sclerosis: Pathogenesis, Mechanisms, and Therapeutic Perspectives
Yang, E. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178419 · Cited by 5
From Mutations to Microbes: Investigating the Impact of the Gut Microbiome on Repeat Expansion Disorders
Das, S., Patel, M., Khandelwal, S., Rawat, R., Shukla, S., Kumari, A., Singh, K., & Kumar, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70278 · Cited by 3
Gut microbiota and ALS: cause, consequence or correlation? - a systematic review
Chakraborty, D. K., Roy, T., Ngo, S. T., Al‐Chalabi, A., & Khleifat, A. A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1774417 · Cited by 3
Taxonomic and functional remodeling of the gut microbiota during aging and implications for microbiota-derived biomarkers
Tekin, B., & Gurbanov, R. (2026) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-026-05017-6 · Cited by 4
Altered microbiome influence on the enteric neuromuscular system in amyotrophic lateral sclerosis (ALS)
Manusha, S., Varsha, N., Varshini, R., Sivamani, Y., Pokkuluri, K. S., & Elayaperumal, S. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.04.006 · Cited by 3
C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen
McCourt, B. T., Lemr, K., Chakrabarti, S., Woidke, E., Ramaiah, S., Singh, V., Sangwan, N., Brown, J. M., Cominelli, F., Rodriguez‐Palacios, A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116906 · Cited by 3
The Microbiome Epoch: Cracking the Cardiovascular-Neurodegenerative Disorder Code
Parolini, C., & Amedei, A. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl47174 · Cited by 2
Immunology and microbiome: Implications for motor systems
Mahjoub, Y., & Martino, D. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-98818-6.00001-7 · Cited by 2
Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis
Pribac, M., Moțățăianu, A., Andone, S. R., Mardale, E., & Nemeth, S. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050271 · Cited by 3
The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis
Saadh, M. J., Dhiaa, S. M., Bansal, P., Dabis, H. K., Katyal, A., Saraswat, V., Ibrahim, A. A., Kadem, R. U., & Ubaid, M. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-024-00292-9 · Cited by 2
Neurodegenerative Diseases and the Gut Microbiota
Cabré, S., O’Riordan, K. J., & Cryan, J. F. (2022) · Progress in inflammation research · doi:10.1007/978-3-030-91051-8_11 · Cited by 2
Human Microbiota Impact on the Efficacy of Pharmacological Treatments
Siraj, M., Siraj, H., Miran, S., & Hussain, F. (2024) · Advances in medical technologies and clinical practice book series · doi:10.4018/979-8-3693-2333-5.ch011 · Cited by 2
Integrative genomics and functional immunology reveal Clostridia species as modulators of neuroinflammation in amyotrophic lateral sclerosis
Wang, S., Jiang, H., & Yao, T. (2025) · Inflammation Research · doi:10.1007/s00011-025-02105-5 · Cited by 2
Cerebrospinal Fluid Metabolites Mediate the Impact of Gut Microbiota on Amyotrophic Lateral Sclerosis: Novel Insights From Mendelian Randomization
Fu, Y., Su, T., Cao, J., Lang, Y., Yin, X., Shao, J., & Cui, L. (2025) · Acta Neurologica Scandinavica · doi:10.1155/ane/5582939 · Cited by 1
Microbiota as a regulator of brain vulnerability across lifespan and disease contexts
Santerre, M., Shcherbik, N., & Sawaya, B. E. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03824-0 · Cited by 1
Update Review of the Relationship Between Gut Microbiota and Neurodegenerative Diseases
Wang, Y., Jing, G., Fu, Y., Li, Y., & Wu, C. (2024) · Diseases & Research · doi:10.54457/dr.202401007 · Cited by 1
Interplay Between Gut-microbiota and Neurodegeneration
Ashique, S., Pal, R., Kumar, S., Verma, B., Kumar, N., Kahwa, I., Farid, A., Mishra, N., Kumar, P., & Taghizadeh‐Hesary, F. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815238754124010009 · Cited by 1
Behavioral and molecular consequences of a ‘double-hit’ challenge on the pathogenesis of mouse models of depression and amyotrophic lateral sclerosis (ALS)
Трофимов, А. Н. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20240205at · Cited by 1
Human Microbiome and the Neurological Disorders
Pamanji, R., & Selvin, J. (2023) · Springer eBooks · doi:10.1007/978-981-99-1463-0_8
Oxisteróis e sua relação com a neuroinflamação na esclerose lateral amiotrófica
Lima, R. S. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2023.tde-12122023-105206
Role of Gastrointestinal Dysbiosis in the Development and Progression of Nervous System Diseases: A Review of the Literature
Daquilema, J. F. C., Andrade, P. G. D., Ocampo, T. M. S., Zhumi, E. J. A., Bustos, E. A. S., & Guaman, S. E. Z. (2024) · Revista de Gestão Social e Ambiental · doi:10.24857/rgsa.v18n12-228
Oxysterol Alterations in SOD1G93A ALS Rats: 25-Hydroxycholesterol and LPS-Binding Protein in Disease ProgressionPreprint
Lima, R. S., Santos, R. S., Chaves‐Filho, A. B., Trzan, I. F. L., Inague, A., de Faria, R. L., Dantas, L. S., Pinto, I. F. D., de Medeiros, M. H. G., Steiner, A. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.650333

Authors: Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., & Berry, J. D.
Affiliations: Massachusetts General Hospital (US)
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Broad Institute (US)
Harvard University (US)
Brigham and Women's Hospital (US)
ORCID: Abu-Ali, Galeb
Chan, James
Cortese, Marianna
Xavier, Ramnik
Huttenhower, Curtis
Ascherio, Alberto
Berry, James D.
Venue: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Publisher: Informa UK Limited
Published: 2020-11-02
Volume: 22
Issue: 3-4
Pages: 186-194
ISSN: 2167-8421 (ISSN-L)
2167-9223
DOI: 10.1080/21678421.2020.1828475
OpenAlex: W3096334056
Cited by: 123
References: 40
Citations by year: 2026: 19 · 2025: 23 · 2024: 28 · 2023: 20 · 2022: 24 · 2021: 8 · 2020: 1
FWCI: 4.30
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: ALS Finding a Cure
Winthrop Family Fund in ALS Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: amyotrophic lateral sclerosis, gut microbiota, butyrate-producing bacteria, Eubacterium rectale, Roseburia intestinalis, microbial community structure, intestinal barrier integrity, inflammation, neurodegenerative diseases, risk factors, constipation
MeSH terms: Clostridiales, Eubacteriales, Gastrointestinal Microbiome, Amyotrophic Lateral Sclerosis, Humans, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The human gut microbiota in people with amyotrophic lateral sclerosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks