The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Plant derived edible nanoparticles as a new therapeutic approach against diseases
Open accessAbstract
In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as extracellular messengers to mediate cell-cell communication in a manner similar to the exosomes secreted by mammalian cells. Notably, such nanoparticles are edible. Moreover, given the proper origin and cargo, plant derived edible nanoparticles could function in interspecies communication and may serve as natural therapeutics against a variety of diseases. In addition, nanoparticles made of plant-derived lipids may be used to efficiently deliver specific drugs. Plant derived edible nanoparticles could be more easily scaled up for mass production, compared to synthetic nanoparticles. In this review, we discuss recent significant developments pertaining to plant derived edible nanoparticles and provide insight into the use of plants as a bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles.
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“Even plant-derived exosomes have been characterized and shown to have structures similar to mammalian exosomes to mediate plant–animal intercellular communication [5].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [5]
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Metadata
- Authors
- Zhang, M., Viennois, E., Xu, C., & Merlin, D.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Zhang, Mingzhen
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2016-02-11
- Volume
- 4
- Issue
- 2
- Pages
- e1134415
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- PMC
- PMC4910829
- OpenAlex
- W2340580991
- Cited by
- 311
- References
- 78
- Citations by year
- 2026: 34 · 2025: 32 · 2024: 43 · 2023: 44 · 2022: 46 · 2021: 48 · 2020: 27 · 2019: 14 · 2018: 13 · 2017: 5 · 2016: 5
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Tissue Barriers (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Crohn's and Colitis Foundation (329228)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071594)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- extracellular vesicles, microRNA, bioactive lipids, plant proteins, interspecies communication, drug delivery, plant-based therapeutics
- MeSH terms
- Administration, Oral, Animals, Humans, Plant Extracts, Nanoparticles, Exosomes
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