Plant derived edible nanoparticles as a new therapeutic approach against diseases

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Liposomal drug delivery systems: From concept to clinical applications

Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839

Identification and proteomic profiling of exosomes in human urine

Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162

Functional delivery of viral miRNAs via exosomes

Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Würdinger, T., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,672

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643

Exosomal-like vesicles are present in human blood plasma

Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348

Quantitative and stoichiometric analysis of the microRNA content of exosomes

Chevillet, J. R., Kang, Q., Ruf, I. K., Briggs, H., Vojtech, L. N., Hughes, S. M., Cheng, H. H., Arroyo, J. D., Meredith, E. K., Gallichotte, E. N., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408301111 · Cited by 1,137

Radioactive Labeling of Milk-Derived Exosomes with 99mTc and In Vivo Tracking by SPECT Imaging

González, M. I., Martín‐Duque, P., Desco, M., & Salinas, B. (2020) · Nanomaterials · doi:10.3390/nano10061062 · Cited by 74

Plant-derived exosome-like nanovesicles: A novel nanotool for disease therapy

Jin, Z., Na, J., Lin, X., Jiao, R., Liu, X., & Huang, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30630 · Cited by 72

Application of Emerging Plant-Derived Nanoparticles as a Novel Approach for Nano-Drug Delivery Systems

Sarvarian, P., Samadi, P., Gholipour, E., Asenjan, K. S., Hojjat‐Farsangi, M., Motavalli, R., Khiavi, F. M., & Yousefi, M. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1891094 · Cited by 69

A Timely Review of Cross-Kingdom Regulation of Plant-Derived MicroRNAs

Li, D., Yang, J., Yang, Y., Liu, J., Li, H., Li, R., Cao, C., Shi, L., Wu, W., & He, K. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.613197 · Cited by 69

In Vitro Effects of Tartary Buckwheat-Derived Nanovesicles on Gut Microbiota

Liu, Y., Tan, M.-L., Zhu, W., Cao, Y.-N., Peng, L., Yan, Z., & Zhao, G. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07658 · Cited by 68

Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation

Xu, Y., Wang, Q., Feng, Y., Firempong, C. K., Zhu, Y., Omari‐Siaw, E., Zheng, Y., Pu, Z., Xu, X., & Yu, J. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.10.007 · Cited by 67

Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

Yu, L., Deng, Z., Liu, L., Zhang, W., & Wang, C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.584391 · Cited by 66

Revisiting the therapeutic potential of gingerols against different pharmacological activities

Sharma, S., Shukla, M. K., Sharma, K. C., Tirath, Kumar, L., Anãl, J. M. H., Upadhyay, S. K., Bhattacharyya, S., & Kumar, D. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02372-7 · Cited by 80

Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications

Wei, Q.-Y., He, K.-M., Chen, J.-L., Xu, Y., & Lau, A. T. Y. (2019) · Molecules · doi:10.3390/molecules24234246 · Cited by 65

Exosomes in Disease Therapy: Plant-Derived Exosome-Like Nanoparticles Current Status, Challenges, and Future Prospects

Song, Y., Feng, N., Yu, Q. B., Li, Y., Meng, M., Yang, X. W., Gan, Z., Xu, T., Tang, C., & Zhang, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s540094 · Cited by 75

Plant-derived exosome-like nanovesicles: a novel therapeutic perspective for skin diseases

Liu, H., Dong, T., Dong, C., Yang, F., Zhou, Q., Guan, C., & Wang, W. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03715-1 · Cited by 76

Advancing cancer therapy: Nanomaterial-based encapsulation strategies for enhanced delivery and efficacy of curcumin

Yan, Y., Kulsoom, Sun, Y., Li, Y., Wang, Z., Li, X., & Wang, F. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101963 · Cited by 71

Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases

Kahroba, H., & Taghipour, Y. D. (2020) · Biochimie · doi:10.1016/j.biochi.2020.02.011 · Cited by 61

Trends in the biological functions and medical applications of extracellular vesicles and analogues

Zhao, Y., Li, X., Zhang, W., Yu, L., Wang, Y., Deng, Z., Liu, M., Mo, S., Wang, R., Zhao, J., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.012 · Cited by 63

Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease

Li, J., Luo, T., Wang, D., Zhao, Y., Jin, Y., Yang, G., & Zhang, X. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.01.035 · Cited by 65

A comprehensive review on ginger-derived exosome-like nanoparticles as feasible therapeutic nano-agents against diseases

Bahri, F., Mansoori, M., Vafaei, S., Fooladi, S., Mir, Y., Mehrabani, M., Hozhabri, Y., Nematollahi, M. H., & Iravani, S. (2024) · Materials Advances · doi:10.1039/d3ma00856h · Cited by 63

Immunostimulatory Potential of Extracellular Vesicles Isolated from an Edible Plant, Petasites japonicus, via the Induction of Murine Dendritic Cell Maturation

Han, J. M., Song, H.-Y., Lim, S.-T., Kim, K., Seo, H. S., & Byun, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910634 · Cited by 58

Olea europaea leaf exosome-like nanovesicles encapsulated in a hyaluronic acid / tannic acid hydrogel dressing with dual “defense-repair” effects for treating skin photoaging

Wang, Z., Yuan, J., Xu, Y., Shi, N., Lin, L., Wang, R., Dai, R., Xu, L., Hao, N., & Li, Q. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101103 · Cited by 64

Advanced research on extracellular vesicles based oral drug delivery systems

Song, M., Cui, M., Fang, Z., & Liu, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.043 · Cited by 53

Comparison of two isolation methods of tobacco-derived extracellular vesicles, their characterization and uptake by plant and rat cells

Kocholatá, M., Průšová, M., Malinská, H. A., Malý, J., & Janoušková, O. (2022) · Scientific Reports · doi:10.1038/s41598-022-23961-9 · Cited by 55

Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine

Shkryl, Y., Tsydeneshieva, Z., Degtyarenko, A. I., Yugay, Y., Balabanova, L., Rusapetova, T., & Bulgakov, V. P. (2022) · Applied Sciences · doi:10.3390/app12168262 · Cited by 58

Exosome-like Nanoparticles: A New Type of Nanocarrier

Fernandes, M., Lopes, I., Teixeira, J., Botelho, C., & Gomes, A. C. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190129142604 · Cited by 51

Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine

Leggio, L., Arrabito, G., Ferrara, V., Vivarelli, S., Paternò, G., Marchetti, B., Pignataro, B., & Iraci, N. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000731 · Cited by 49

Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids

Alfutaimani, A. S., Alharbi, N. K., Alahmari, A. S., Alqabbani, A. A., & Aldayel, A. M. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100305 · Cited by 56

Edible plant extracellular vesicles: An emerging tool for bioactives delivery

Fan, S., Chen, J., Tang, C.-H., Zhao, Q., Zhang, J., & Qin, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1028418 · Cited by 53

Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment

Yi, C., Lu, L., Li, Z., Guo, Q., Ou, L., Wang, R., & Tian, X. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01621-x · Cited by 53

Hemp-Derived Nanovesicles Protect Leaky Gut and Liver Injury in Dextran Sodium Sulfate-Induced Colitis

Eom, J., Choi, S.-H., Kim, H., Kim, D.-H., Bae, J.-H., Kwon, G.-S., Lee, D.-H., Hwang, J.-H., Kim, D., Baek, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179955 · Cited by 48

pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

Oshi, M. A., Lee, J., Kim, J., Hasan, N., Im, E., Jung, Y., & Yoo, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091412 · Cited by 47

Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice

Raimo, R. D., Mizzoni, D., Spada, M., Dolo, V., Fais, S., & Logozzi, M. (2023) · Antioxidants · doi:10.3390/antiox12061169 · Cited by 50

Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment

Zhao, Y., Tan, H., Zhang, J., Pan, B., Wang, N., Chen, T., Shi, Y., & Wang, Z. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s432279 · Cited by 47

Extracellular Vesicles in Therapeutics: A Comprehensive Review on Applications, Challenges, and Clinical Progress

Goo, J., Lee, Y., Lee, J., Kim, I., & Jeong, C. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16030311 · Cited by 51

Selenium Biofortification Enhanced miR167a Expression in Broccoli Extracellular Vesicles Inducing Apoptosis in Human Pancreatic Cancer Cells by Targeting IRS1

Wang, X.-H., Wu, B., Sun, G., He, W., Gao, J., Huang, T., Liu, J., Zhou, Q., He, X., Zhang, S., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s394133 · Cited by 49

Extraction, Isolation, and Component Analysis of Turmeric-Derived Exosome-like Nanoparticles

Wei, Y., Cai, X., Wu, Q., Liao, H., Liang, S., Fu, H., Xiang, Q., & Zhang, S. (2023) · Bioengineering · doi:10.3390/bioengineering10101199 · Cited by 46

Plant-derived vesicle-like nanoparticles: A new tool for inflammatory bowel disease and colitis-associated cancer treatment

Fang, X., Feng, J., Zhu, X., Feng, D., & Zheng, L. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.021 · Cited by 47

A review on separation and application of plant‐derived exosome‐like nanoparticles

Liu, Y., Xiao, S., Wang, D., Qin, C., Wei, H., & Li, D. (2024) · Journal of Separation Science · doi:10.1002/jssc.202300669 · Cited by 51

Plant-derived exosomes in therapeutic nanomedicine, paving the path toward precision medicine

Zheng, M., Chavda, V. P., Vaghela, D. A., Bezbaruah, R., Gogoi, N. R., Patel, K., Kulkarni, M., Shen, B., & Singla, R. K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156087 · Cited by 49

Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: current Progress and Future Perspectives

Liu, X., Lou, K., Zhang, Y. ‐. P., Li, C., Wei, S., & Feng, S. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s463145 · Cited by 50

Evidence of transfer of miRNAs from the diet to the blood still inconclusive

Mar‐Aguilar, F., Arreola-Triana, A. E., Mata-Cardona, D., González-Villasana, V., Rodrı́guez-Padilla, C., & Reséndez‐Pérez, D. (2020) · PeerJ · doi:10.7717/peerj.9567 · Cited by 45

New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery

Shinge, S. A. U., Xiao, Y., Xia, J., Liang, Y., & Duan, L. (2022) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2021.25 · Cited by 44

Evaluation of Antioxidant Activity and Drug Delivery Potential of Cell-Derived Extracellular Vesicles from Citrus reticulata Blanco cv. ‘Dahongpao’

Li, S., Ye, Z., Zhao, L., Yao, Y., & Zhou, Z. (2023) · Antioxidants · doi:10.3390/antiox12091706 · Cited by 48

Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment

Choi, S.-H., Eom, J., Kim, H., Seo, W., Kwun, H., Kim, D., Kim, J., & Cho, Y. (2023) · Biomaterials Science · doi:10.1039/d3bm00591g · Cited by 42

Chinese herbal medicine-derived extracellular vesicles as novel biotherapeutic tools: present and future

Zhang, J., Tian, S., Guo, L., Zhao, H., Mao, Z., & Miao, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05892-3 · Cited by 42

Grape exosome-like nanoparticles: A potential therapeutic strategy for vascular calcification

Teng, Y., He, J., Zhong, Q., Zhang, Y., Lu, Z., Guan, T., Pan, Y., Luo, X., Feng, W., & Ou, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1025768 · Cited by 41

Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue

Bian, Y., Li, W., Jiang, X., Yin, F., Yin, L., Zhang, Y., Guo, H., & Liu, J. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109249 · Cited by 45

Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases

Okeke, E. S., Nweze, E. J., Anaduaka, E. G., Okoye, C. O., Anosike, C. A., Joshua, P. E., & Ezeorba, T. P. C. (2023) · 3 Biotech · doi:10.1007/s13205-023-03713-w · Cited by 44

Therapeutic potential and pharmacological significance of extracellular vesicles derived from traditional medicinal plants

Wu, P., Wu, W., Zhang, S., Han, J., Liu, C., Han, Y., Chen, X., & Chen, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1272241 · Cited by 41

Isolation and characterization of ginseng-derived exosome-like nanoparticles with sucrose cushioning followed by ultracentrifugation

Kim, J., Lee, Y., Wang, J., Kim, Y. K., & Kwon, I. K. (2022) · SN Applied Sciences · doi:10.1007/s42452-022-04943-y · Cited by 43

Taraxacum officinale-derived exosome-like nanovesicles modulate gut metabolites to prevent intermittent hypoxia-induced hypertension

Zhang, X., Pan, Z., Wang, Y., Liu, P., & Hu, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114572 · Cited by 40

Plum-Derived Exosome-like Nanovesicles Induce Differentiation of Osteoblasts and Reduction of Osteoclast Activation

Park, Y.-S., Kim, H., Hwang, J.-H., Eom, J., Kim, D.-H., Park, J., Tae, H., Lee, S., Yoo, J. G., Kim, J., et al. (2023) · Nutrients · doi:10.3390/nu15092107 · Cited by 43

Autologous Exosome Transfer: A New Personalised Treatment Concept to Prevent Colitis in a Murine Model

Yang, C., Zhang, M., Sung, J. J., Wang, L., Jung, Y., & Merlin, D. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz184 · Cited by 39

Extracellular vesicles and exosome-like nanovesicles as pioneering oral drug delivery systems

Mondal, J., Pillarisetti, S., Junnuthula, V., Surwase, S. S., Hwang, S. R., Park, I., & Lee, Y.-K. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1307878 · Cited by 39

A Comprehensive Review on Exploring the Potential of Phytochemicals and Biogenic Nanoparticles for the Treatment of Antimicrobial-Resistant Pathogenic Bacteria

Murugan, S., Senthilvelan, T., Govindasamy, M., & Thangavel, K. (2025) · Current Microbiology · doi:10.1007/s00284-025-04064-w · Cited by 42

Do Ginger-Derived Nanoparticles Represent an Attractive Treatment Strategy for Inflammatory Bowel Diseases?

Zhang, M., Collins, J. F., & Merlin, D. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0353 · Cited by 37

Plant-derived nanoparticles and plant virus nanoparticles: Bioactivity, health management, and delivery potential

Liu, C., Yu, Y., Fang, L., Wang, J., Sun, C., Li, H., Zhuang, J., & Sun, C. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2204375 · Cited by 38

Before Translating Extracellular Vesicles into Personalized Diagnostics and Therapeutics: What We Could Do

Cheng, C. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00185 · Cited by 35

Click chemistry-based modified exosomes: Towards enhancing precision in cancer theranostics

Mukerjee, N., Maitra, S., Kaur, M., Rekha, M. M., Soothwal, P. K., Arora, I., Thorat, N. D., Sharma, P. K., & Kaushik, A. K. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160915 · Cited by 33

Suppression of inflammatory responses in macrophages by onion-derived extracellular vesicles

Kang, S. J., Kim, S. E., Seo, M., Kim, E., & Rhee, W. J. (2022) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2022.08.011 · Cited by 32

Exosomes in diagnostic and therapeutic applications of ovarian cancer

Bhavsar, D., Raguraman, R., Kim, D., Ren, X., Munshi, A., Moore, K. N., Sikavitsas, V. I., & Ramesh, R. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01417-0 · Cited by 34

Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics

Shi, L., Guo, C., Fang, M., Yang, Y., Yin, F., & Shen, Y. C. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1512047 · Cited by 30

Exosomes as Carriers for Antitumor Therapy

Li, Y., Zhang, Y., Li, Z., Zhou, K., & Feng, N. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00417 · Cited by 31

Nanoparticle-based therapeutics of inflammatory bowel diseases: a narrative review of the current state and prospects

Yang, M., Zhang, Y., Ma, Y., Yan, X., Gong, L., Zhang, M., & Zhang, B. (2020) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000078 · Cited by 33

Onion (Allium cepa L.)-Derived Nanoparticles Inhibited LPS-Induced Nitrate Production, However, Their Intracellular Incorporation by Endocytosis Was Not Involved in This Effect on RAW264 Cells

Yamasaki, M., Yamasaki, Y., Furusho, R., Kimura, H., Kamei, I., Sonoda, H., Ikeda, M., Oshima, T., Ogawa, K., & Nishiyama, K. (2021) · Molecules · doi:10.3390/molecules26092763 · Cited by 31

Plant Nanovesicles for Essential Oil Delivery

Zuzarte, M., Vitorino, C., Salgueiro, L., & Girão, H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122581 · Cited by 30

Advances in the Therapeutic Applications of Plant-Derived Exosomes in the Treatment of Inflammatory Diseases

Wei, X., Li, X., Zhang, Y., Wang, J., & Shen, S. (2023) · Biomedicines · doi:10.3390/biomedicines11061554 · Cited by 30

Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I

Akao, Y., Kuranaga, Y., Heishima, K., Sugito, N., Morikawa, K., Ito, Y., Soga, T., & Ito, T. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108922 · Cited by 32

Prospects of plant-derived exosome-like nanocarriers in oncology and tissue engineering

Rahmati, S., Karimi, H., Alizadeh, M., Khazaei, A. H., Paiva‐Santos, A. C., Rezakhani, L., & Sharifi, E. (2023) · Human Cell · doi:10.1007/s13577-023-00994-4 · Cited by 29

Covalently Labeled Fluorescent Exosomes for In Vitro and In Vivo Applications

González, M. I., González‐Arjona, M., Santos‐Coquillat, A., Vaquero, J., Vázquez-Ogando, E., de Molina-Iracheta, A., Peinado, H., Desco, M., & Salinas, B. (2021) · Biomedicines · doi:10.3390/biomedicines9010081 · Cited by 28

Orange-derived and dexamethasone-encapsulated extracellular vesicles reduced proteinuria and alleviated pathological lesions in IgA nephropathy by targeting intestinal lymphocytes

Zhang, W., Yuan, Y., Li, X., Luo, J., Zhou, Z., Yu, L., & Wang, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900963 · Cited by 28

A mini-review: Advances in plant-derived extracellular vesicles as nano-delivery systems for tumour therapy

Zhu, Y., Zhou, X., & Yao, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1076348 · Cited by 27

From Garden to Clinic: Plant‑Derived Exosome‑Like Nanovesicles for Precision Oxidative Stress Therapy

Yang, T., He, M., Huang, J., Zhang, D., Song, T., Tan, J., Wang, X., Lu, Y., Kong, Q., & Zhang, J. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s569204 · Cited by 30

Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo

Arai, M., Komori, H., Fujita, D., & Tamai, I. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03018-8 · Cited by 27

Citrus Exosome-like Nanoparticles Reversed High-Fat Diet-Induced Microbiota Dysbiosis and Associated Short-Chain Fatty Acid Production

Zhan, M., Cai, Y., Zhao, C., Chen, B., Wang, X., Shen, P., Han, Y., Song, M., Cao, Y., & Xiao, H. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c04523 · Cited by 29

Applications of emerging extracellular vesicles technologies in the treatment of inflammatory diseases

Lou, K., Luo, H., Jiang, X., & Feng, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1364401 · Cited by 24

Extracellular vesicle-based macromolecule delivery systems in cancer immunotherapy

Chen, H., Sun, T., & Jiang, C. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.014 · Cited by 25

Characterization of anti-proliferative and anti-oxidant effects of nano-sized vesicles from Brassica oleracea L. (Broccoli)

Hossain, M. N., Leo, V. D., Tamborra, R., Laselva, O., Ingrosso, C., Daniello, V., Catucci, L., Losito, I., Sollitto, F., Loizzi, D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17899-1 · Cited by 25

Establishing Salvia miltiorrhiza-Derived Exosome-like Nanoparticles and Elucidating Their Role in Angiogenesis

Zhang, S., Xia, J., Zhu, Y., Dong, M., & Wang, J. (2024) · Molecules · doi:10.3390/molecules29071599 · Cited by 24

Goji-Derived Exosomes-Like Nanoparticles Ameliorate Alcohol-Induced Acute Liver Injury by modulating gut microbiota and metabolites

Guo, L., Ding, Q.-Y., Duan, W., Guan, Q., Ren, Y., Xue, Y., Xu, Z.-H., & Geng, Y. (2025) · Food & medicine homology. · doi:10.26599/fmh.2026.9420081 · Cited by 24

Anti-SARS-CoV-2 Strategies and the Potential Role of miRNA in the Assessment of COVID-19 Morbidity, Recurrence, and Therapy

Narożna, M., & Rubiś, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168663 · Cited by 26

Novel Technologies for Exosome and Exosome-like Nanovesicle Procurement and Enhancement

Martínez-Santillán, A., & González‐Valdez, J. (2023) · Biomedicines · doi:10.3390/biomedicines11051487 · Cited by 24

MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion–Transporting Peptide 2B1/SLCO2B1 in Caco-2 Cells

Komori, H., Fujita, D., Shirasaki, Y., Zhu, Q., Iwamoto, Y., Nakanishi, T., Nakajima, M., & Tamai, I. (2021) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000380 · Cited by 22

Demystifying phytoconstituent-derived nanomedicines in their immunoregulatory and therapeutic roles in inflammatory diseases

Chen, F., & Liu, Q. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114317 · Cited by 24

Plant extracellular vesicles and their potential in human health research, the practical approach

Kocholatá, M., Malý, J., Martinec, J., & Malinská, H. A. (2022) · Physiological Research · doi:10.33549/physiolres.934886 · Cited by 22

Role of Exosomal MicroRNAs in Cell-to-Cell Communication

Tastan, B., Tarakcioglu, E., Birinci, Y., Park, Y., & Genç, Ş. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1170-8_14 · Cited by 20

Nanoscale Phytosomes as an Emerging Modality for Cancer Therapy

Kadriya, A., & Falah, M. (2023) · Cells · doi:10.3390/cells12151999 · Cited by 27

Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder

Wu, Q., Duan, W.-Z., Chen, J., Zhao, X.-P., Li, X., Liu, Y., Ma, Q., Xue, Z., & Chen, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.843412 · Cited by 21

Extracellular vesicles derived from microgreens of Raphanus sativus L. var. caudatus Alef contain bioactive macromolecules and inhibit HCT116 cells proliferation

Kaimuangpak, K., Tamprasit, K., Thumanu, K., & Weerapreeyakul, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-19950-7 · Cited by 20

Fisetin-loaded grape-derived nanoparticles improve anticancer efficacy in MOLT-4 cells

Sarvarian, P., Samadi, P., Gholipour, E., khodadadi, M., Pourakbari, R., Akbarzadelale, P., & Shamsasenjan, K. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.040 · Cited by 20

Extracellular vesicles for developing targeted hearing loss therapy

Pan, X., Li, Y., Huang, P., Staecker, H., & He, M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.050 · Cited by 23

Formidable challenges to the notion of biologically important roles for dietary small RNAs in ingesting mammals

Chan, S. Y., & Snow, J. W. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0561-7 · Cited by 23

Plant-derived nanoparticles as alternative therapy against Diarrheal pathogens in the era of antimicrobial resistance: A review

Abolarinwa, T. O., Ajose, D. J., Oluwarinde, B. O., Fri, J., Montso, P. K., Fayemi, O. E., Aremu, A. O., & Ateba, C. N. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1007115 · Cited by 20

Artificially induced in situ macrophage polarization: An emerging cellular therapy for immuno-inflammatory diseases

Chatterjee, O., & Sur, D. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176006 · Cited by 22

Emerging Roles of Extracelluar Vesicles Derived from Bacteria, Mammalian or Plant Cells in the Pathogenesis and Clinical Application of Neurodegenerative Diseases

Li, Y., Zhou, C., Liu, H., Cai, T., & Fan, H. (2024) · Biomolecules · doi:10.3390/biom14030312 · Cited by 20

The Expanding Role of Vesicles Containing Aquaporins

Martínez‐Ballesta, M. D. C., García-Ibáñez, P., Yepes‐Molina, L., Ríos, J. J., & Carvajal, M. (2018) · Cells · doi:10.3390/cells7100179 · Cited by 17

Preparation and Characterization of Ginger Lipid-derived Nanoparticles for Colon-targeted siRNA Delivery

Sung, J., Yang, C., Collins, J. F., & Merlin, D. (2020) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3685 · Cited by 18

Nanoencapsulation of Pomegranate Extract to Increase Stability and Potential Dermatological Protection

Yepes‐Molina, L., Hernández, J. A., & Carvajal, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020271 · Cited by 19

New Nanovesicles from Prickly Pear Fruit Juice: A Resource with Antioxidant, Anti-Inflammatory, and Nutrigenomic Properties

Naselli, F., Volpes, S., Cardinale, P. S., Palumbo, F. S., Cancilla, F., Lopresti, F., Villanova, V., Girgenti, A., Nuzzo, D., Caradonna, F., et al. (2024) · Cells · doi:10.3390/cells13211756 · Cited by 16

Blueberry-derived exosome like nanovesicles carry RNA cargo into HIEC-6 cells and down-regulate LPS-induced inflammatory gene expression: A proof-of-concept study

Cox, S. N., Porcelli, V., Romano, S., Palmieri, L., & Fratantonio, D. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110266 · Cited by 16

Tea leaf exosome-like nanoparticles (TELNs) improve oleic acid-induced lipid metabolism by regulating miRNAs in HepG-2 cells

Lei, X., Li, H., Chen, S., Li, B., Xia, H., Li, J., Guan, F., & Ge, J. (2025) · Bioresources and Bioprocessing · doi:10.1186/s40643-025-00844-1 · Cited by 16

Current progress of plant-derived exosome-like nanovesicles on the regulation of osteoporosis and osteoarthritis

Xia, X., Zhu, J., Xu, X., Wang, W., Zhao, R., Wu, K., Huang, H., Qian, Y., Luo, Z., Xu, F., et al. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2549524 · Cited by 23

Plant-Derived Edible Nanoparticles and miRNAs: Emerging Frontier for Therapeutics and Targeted Drug-Delivery

Iravani, S., & Varma, R. S. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b00954 · Cited by 136

Recent developments in plant‐derived edible nanoparticles as therapeutic nanomedicines

Jain, N., Pandey, M., Sharma, P., Gupta, G., Gorain, B., & Dua, K. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14479 · Cited by 11

Edible plant-derived exosomes and their therapeutic applicatons

Koçak, P., Kala, E. Y., Güneş, M. S. A., Ünsal, N., Yılmaz, H., Metin, B., & Şahi̇n, F. (2020) · Cited by 5

Edible Nanoparticles – An Overview

Moncy, A. T. P., Selvasudha, N., & Vasanthi, H. R. (2024) · SBV Journal of Basic Clinical and Applied Health Science · doi:10.4103/sbvj.sbvj_19_24

Plant-Derived Edible Nanoparticles and miRNAs

Tiriya, M., Kumar, A. M., & Kumar, V. (2025) · Sustainability Sciences in Asia and Africa · doi:10.1007/978-981-96-7756-6_1