The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Impaired Masking Responses to Light in Melanopsin‐Knockout Mice
Abstract
There are two ways in which an animal can confine its behavior to a nocturnal or diurnal niche. One is to synchronize an endogenous clock that in turn controls the sleep-wake cycle. The other is to respond directly to illumination with changes in activity. In mice, high illumination levels suppress locomotion (negative masking) and low illumination levels enhance locomotion (positive masking). To investigate the role of the newly discovered opsin-like protein melanopsin in masking, we used 1 h and 3 h pulses of light given in the night, and also a 3.5:3.5 h light-dark (LD) cycle. Mice lacking the melanopsin gene had normal enhancement of locomotion in the presence of dim lights but an impaired suppression of locomotion in the presence of bright light. This impairment was evident only with lights in the order of 10 lux or brighter. This suggests that melanopsin in retinal ganglion cells is involved in masking, as it is in pupil contraction and phase shifts. Melanopsin is especially important in maintaining masking responses over long periods.
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Citations
Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Self-citationMelanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting
Panda, S., Sato, T. K., Castrucci, A. M., Rollag, M. D., DeGrip, W. J., Hogenesch, J. B., Provencio, I., & Kay, S. A. (2002) · Science · doi:10.1126/science.1076848 · Cited by 861
High Sensitivity of the Human Circadian Melatonin Rhythm to Resetting by Short Wavelength Light
Lockley, S. W., Brainard, G. C., & Czeisler, C. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030570 · Cited by 782
Cited by
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
Self-citationThe circadian visual system, 2005
Morin, L. P., & Allen, C. N. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.08.003 · Cited by 784
Gooley, J. J., Rajaratnam, S. M. W., Brainard, G. C., Kronauer, R. E., Czeisler, C. A., & Lockley, S. W. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000741 · Cited by 447
Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Do, M. T. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.016 · Cited by 312
Metadata
- Authors
- Mrosovsky, N., & Hattar, S.
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 20
- Issue
- 6
- Pages
- 989-999
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2164172218
- Cited by
- 197
- References
- 5
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
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