The DOI matches its Crossref record; 258 of the 258 references it cites were found in a registry or an index.
Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior
Open accessAbstract
SUMMARY The mammalian visual system encodes information over a remarkable breadth of spatiotemporal scales and light intensities. This performance originates with its complement of photoreceptors: the classic rods and cones, as well as the intrinsically photosensitive retinal ganglion cells (ipRGCs). IpRGCs capture light with a G protein-coupled receptor called melanopsin, depolarize like photoreceptors of invertebrates such as Drosophila, discharge electrical spikes, and innervate dozens of brain areas to influence physiology, behavior, perception, and mood. Several visual responses rely on melanopsin to be sustained and maximal, and require ipRGCs to occur at all. IpRGCs fulfill their roles using mechanisms that include an unusual conformation of the melanopsin protein, an extraordinarily slow phototransduction cascade, divisions of labor even among cells of a morphological type, and unorthodox configurations of circuitry. The study of ipRGCs has yielded insight into general topics that include photoreceptor evolution, cellular diversity, and the steps from biophysical mechanisms to behavior.
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Cites
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Measuring and using light in the melanopsin age
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“For example, while broadband light induces sleep in mice, it improves alertness, attention, and reaction time in humans (Lucas et al., 2014).”
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Cited by
Brown, T. M., Brainard, G. C., Cajochen, C., Czeisler, C. A., Hanifin, J. P., Lockley, S. W., Lucas, R. J., Münch, M., O’Hagan, J. B., Peirson, S. N., et al. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001571 · Cited by 659
Cell Atlas of The Human Fovea and Peripheral Retina
Yan, W., Peng, Y.-R., van Zyl, T., Regev, A., Shekhar, K., Juric, D., & Sanes, J. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-66092-9 · Cited by 283
Intrinsically photosensitive retinal ganglion cells of the human retina
Mure, L. S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.636330 · Cited by 151
Spitschan, M., Kervezee, L., Lok, R., McGlashan, E., Najjar, R. P., Allen, A. E., Andersen, M., Bará, S., Blattner, P., Blume, C., et al. (2023) · eBioMedicine · doi:10.1016/j.ebiom.2023.104889 · Cited by 60
Encoding of environmental illumination by primate melanopsin neurons
Liu, A., Milner, E. S., Peng, Y.-R., Blume, H. A., Brown, M. C., Bryman, G. S., Emanuel, A. J., Morquette, P., Viet, N.-M., Sanes, J. R., et al. (2023) · Science · doi:10.1126/science.ade2024 · Cited by 44
Self-citation
Metadata
- Authors
- Do, M. T. H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 104
- Issue
- 2
- Pages
- 205-226
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2982026888
- Cited by
- 312
- References
- 258
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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