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EGF receptor trafficking: consequences for signaling and cancer

Tomas, Alejandra, Futter, Clare E., Eden, Emily R.·2014·Trends in Cell Biology
DOI 10.1016/j.tcb.2013.11.002PMC PMC3884125
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  • Cell surface EGFR is constitutively internalized and recycled back to the plasma membrane without ligand stimulation, and this balance is precisely regulated for maintenance of the cell surface-dominant localization of the receptor.

    “Cell surface EGFR is also constitutively internalized and recycled back to the PM without ligand stimulation; this balance must be precisely regulated for the maintenance of the cell surface-dominant localization of the receptor [3, 4].”

    From Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth (2021) · cites this paper as [4]

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Metadata

Authors
Tomas, A., Futter, C. E., & Eden, E. R.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2014-01
Volume
24
Issue
1
Pages
26-34
ISSN
0962-8924
DOI
10.1016/j.tcb.2013.11.002
PMC
PMC3884125
Cited by
779
References
2
Language
en
Licence

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