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Early Signals in the Mitogenic Response
Abstract
Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.
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Citations
Cited by
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
G-protein-coupled receptors and signaling networks: emerging paradigms
Marinissen, M. J., & Gutkind, J. S. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01678-3 · Cited by 1,049
Lau, L. F., & Nathans, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1182 · Cited by 856
Gutkind, J. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1839 · Cited by 812
Metadata
- Authors
- Rozengurt, E.
- Venue
- Science
- Published
- 1986-10-10
- Volume
- 234
- Issue
- 4773
- Pages
- 161-166
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992472345
- Cited by
- 1,455
- References
- 0
- FWCI
- 58.02
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Early Signals in the Mitogenic Response. https://app.cochat.ai/papers/10.1126/science.3018928
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- Rozengurt, E. (1986). Early Signals in the Mitogenic Response. Science. https://doi.org/10.1126/science.3018928
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
