The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Mutant Rab7 Causes the Accumulation of Cathepsin D and Cation-independent Mannose 6–Phosphate Receptor in an Early Endocytic Compartment
Open accessAbstract
Stable BHK cell lines inducibly expressing wild-type or dominant negative mutant forms of the rab7 GTPase were isolated and used to analyze the role of a rab7-regulated pathway in lysosome biogenesis. Expression of mutant rab7N125I protein induced a dramatic redistribution of cation-independent mannose 6–phosphate receptor (CI-MPR) from its normal perinuclear localization to large peripheral endosomes. Under these circumstances ∼50% of the total receptor and several lysosomal hydrolases cofractionated with light membranes containing early endosome and Golgi markers. Late endosomes and lysosomes were contained exclusively in well-separated, denser gradient fractions. Newly synthesized CI-MPR and cathepsin D were shown to traverse through an early endocytic compartment, and functional rab7 was crucial for delivery to later compartments. This observation was evidenced by the fact that 2 h after synthesis, both markers were more prevalent in fractions containing light membranes. In addition, both were sensitive to HRP-DAB– mediated cross-linking of early endosomal proteins, and the late endosomal processing of cathepsin D was impaired. Using similar criteria, the lysosomal membrane glycoprotein 120 was not found accumulated in an early endocytic compartment. The data are indicative of a post-Golgi divergence in the routes followed by different lysosome-directed molecules.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 1×
“Therefore, we chose to use a tetracycline-controlled expression system that has been shown to be very tightly regulated (Gossen et al., 1994; Gossen and Bujard, 1992).”
Novick, P., Field, C., & Schekman, R. (1980) · Cell · doi:10.1016/0092-8674(80)90128-2 · Cited by 1,449
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., & Zerial, M. (1992) · Cell · doi:10.1016/0092-8674(92)90306-w · Cited by 1,373
Self-citationInduction of mutant dynamin specifically blocks endocytic coated vesicle formation.
Damke, H., Baba, T., Warnock, D. E., & Schmid, S. L. (1994) · The Journal of cell biology · doi:10.1083/jcb.127.4.915 · Cited by 1,204
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
Chavrier, P., Parton, R. G., Hauri, H. P., Simons, K., & Zerial, M. (1990) · Cell · doi:10.1016/0092-8674(90)90369-p · Cited by 1,166
rab5 controls early endosome fusion in vitro
Gorvel, J.-P., Chavrier, P., Zerial, M., & Gruenberg, J. (1991) · Cell · doi:10.1016/0092-8674(91)90316-q · Cited by 1,093
The mannose 6-phosphate receptor and the biogenesis of lysosomes
Griffiths, G., Hoflack, B., Simons, K., Mellman, I., & Kornfeld, S. (1988) · Cell · doi:10.1016/s0092-8674(88)80026-6 · Cited by 855
Self-citationInsulin-like growth factor II receptor as a multifunctional binding protein
Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., & Rutter, W. J. (1987) · Nature · doi:10.1038/329301a0 · Cited by 853
The diversity of Rab proteins in vesicle transport
Novick, P., & Zerial, M. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80025-7 · Cited by 757
EEA1, an Early Endosome-Associated Protein.
Mu, F.-T., Callaghan, J. M., Steele-Mortimer, O., Stenmark, H., Parton, R. G., Campbell, P. L., McCluskey, J., Yeo, J.-P., Tock, E. P. C., & Toh, B.-H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13503 · Cited by 714
Cited by
Rab7: A Key to Lysosome Biogenesis
Bucci, C., Thomsen, P., Nicoziani, P., McCarthy, J., & van Deurs, B. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.467 · Cited by 1,085
Braulke, T., & Bonifacino, J. S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.10.016 · Cited by 811
Receptor-mediated Endocytosis in the Caenorhabditis elegans Oocyte
Grant, B., & Hirsh, D. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.12.4311 · Cited by 607
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
Arighi, C. N., Hartnell, L. M., Aguilar, R. C., Haft, C. R., & Bonifacino, J. S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312055 · Cited by 580
PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins
McEwan, D. G., Popovic, D., Gubas, A., Terawaki, S., Suzuki, H., Stadel, D., Coxon, F. P., Miranda de Stegmann, D., Bhogaraju, S., Maddi, K., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.11.006 · Cited by 563
Metadata
- Authors
- Press, B., Feng, Y., Hoflack, B., & Wandinger-Ness, A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-03-09
- Volume
- 140
- Issue
- 5
- Pages
- 1075-1089
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1945261349
- Cited by
- 267
- References
- 83
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mutant Rab7 Causes the Accumulation of Cathepsin D and Cation-independent Mannose 6–Phosphate Receptor in an Early Endocytic Compartment. https://app.cochat.ai/papers/10.1083/jcb.140.5.1075
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- Press, B., Feng, Y., Hoflack, B., & Wandinger-Ness, A. (1998). Mutant Rab7 Causes the Accumulation of Cathepsin D and Cation-independent Mannose 6–Phosphate Receptor in an Early Endocytic Compartment. The Journal of Cell Biology. https://doi.org/10.1083/jcb.140.5.1075
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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