The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
Open accessAbstract
Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing β-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of β-catenin. This pathway is Siah2 and APC dependent, but GSK-3 and β-TrCP independent. Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote β-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation.
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Cites
Kühl, M., Sheldahl, L. C., Malbon, C. C., & Moon, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12701 · Cited by 517
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
Saneyoshi, T., Kume, S., Amasaki, Y., & Mikoshiba, K. (2002) · Nature · doi:10.1038/417295a · Cited by 322 · cited 7×
“However, our observation that Wnt-5a–induced -catenin inhibition was not rescued by blocking NF-AT or CaMKII activation argues that there may be a NF-AT– and CaMKII-independent pathway that is activated by Wnt-5a signaling to promote -catenin degradation in 293 cells.”
BackgroundInfluentialWg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · cited 3×
“The canonical Wnt signaling can also up-regulate -catenin activity through a GSK-3–independent pathway in a recently published work (Tolwinski et al., 2003).”
BackgroundInfluentialFrizzled-7 signalling controls tissue separation during Xenopus gastrulation
Winklbauer, R., Medina, A., Swain, R. K., & Steinbeisser, H. (2001) · Nature · doi:10.1038/35101621 · Cited by 263 · cited 2×
“19 different Wnt genes have been identified in the mouse and human genomes (http://www.stanford.edu/~rnusse/ wntwindow.html) and they signal through either the canonical pathway or at least two different noncanonical pathways (Kuhl et al., 2000b; Niehrs, 2001; Winklbauer et al., 2001).”
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Cited by
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616
Self-citationRegulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Wnt and calcium signaling: β-Catenin-independent pathways
Kohn, A. D., & Moon, R. T. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.022 · Cited by 730
Metadata
- Authors
- Topol, L., Jiang, X., Choi, H., Garrett-Beal, L., Carolan, P. J., & Yang, Y.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-09-01
- Volume
- 162
- Issue
- 5
- Pages
- 899-908
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2154041910
- Cited by
- 724
- References
- 4
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Topol, L., Jiang, X., Choi, H., Garrett-Beal, L., Carolan, P. J., & Yang, Y. (2003). Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200303158
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
