The DOI matches its Crossref record.
Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
Open accessAbstract
Langerhans cells (LC) form a unique subset of dendritic cells (DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC (dDC). Here, we exploit a novel diphtheria toxin (DT) receptor (DTR)/DT-based system to achieve inducible ablation of LC without affecting the skin environment. Within 24 h after intra-peritoneal injection of DT into Langerin-DTR mice LC are completely depleted from the epidermis and only begin to return 4 wk later. LC deletion occurs by apoptosis in the absence of inflammation and, in particular, the dDC compartment is not affected. In LC-depleted mice contact hypersensitivity (CHS) responses are significantly decreased, although ear swelling still occurs indicating that dDC can mediate CHS when necessary. Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S., & Colonna, M. (2012) · Nature Immunology · doi:10.1038/ni.2360 · Cited by 1,011
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
Merad, M., Ginhoux, F., & Collin, M. (2008) · Nature Reviews Immunology · doi:10.1038/nri2455 · Cited by 850
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., & Jung, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061011 · Cited by 627
Self-citationUse of defined TLR ligands as adjuvants within human vaccines
Duthie, M. S., Windish, H. P., Fox, C. B., & Reed, S. G. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00978.x · Cited by 437
Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung
Landsman, L., Varol, C., & Jung, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2000 · Cited by 322
Self-citationLangerhans cells - the macrophage in dendritic cell clothing
Doebel, T., Voisin, B., & Nagao, K. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.06.008 · Cited by 270
Studying the mononuclear phagocyte system in the molecular age
Chow, A., Brown, B. D., & Merad, M. (2011) · Nature Reviews Immunology · doi:10.1038/nri3087 · Cited by 279
Functions of the aryl hydrocarbon receptor in the skin
Esser, C., Bargen, I., Weighardt, H., Haarmann-Stemmann, T., & Krutmann, J. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0394-4 · Cited by 187
Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2
Nobre, A. R., Risson, E., Singh, D. K., Di Martino, J. S., Cheung, J. F., Wang, J., Johnson, J., Russnes, H. G., Bravo-Cordero, J. J., Birbrair, A., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00179-8 · Cited by 159
Tanaka, H., Matsushima, H., Nishibu, A., Clausen, B. E., & Takashima, A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1106 · Cited by 134
Self-citationLangerhans cells are required for efficient presentation of topically applied hapten to T cells
Bennett, C. L., Noordegraaf, M., Martina, C. A. E., & Clausen, B. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6830 · Cited by 126
Self-citationFu, Q., Gremeaux, L., Luque, R. M., Liekens, D., Chen, J., Buch, T., Waisman, A., Kineman, R., & Vankelecom, H. (2012) · Endocrinology · doi:10.1210/en.2012-1152 · Cited by 105
Zhang, M., Xu, S., Han, Y., & Cao, X. (2011) · Hepatology · doi:10.1002/hep.24029 · Cited by 84
Ferrer, I. R., West, H. C., Henderson, S., Ushakov, D. S., Santos e Sousa, P., Strid, J., Chakraverty, R., Yates, A. J., & Bennett, C. L. (2019) · Science Immunology · doi:10.1126/sciimmunol.aax8704 · Cited by 61
Dendritic Cells and T Cells in the Regulation of Cutaneous Immunity
Loser, K., & Beissert, S. (2007) · Advances in Dermatology · doi:10.1016/j.yadr.2007.07.014 · Cited by 52
Epidermal Langerhans cells are not required for UV-induced immunosuppression
Wang, L., Jameson, S. C., & Hogquist, K. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900235 · Cited by 49
“In the conditional deficiency models, one group found CHS was decreased (24), whereas the other group did not observe any change (14).”
Japtok, L., Schaper, K., Bäumer, W., Radeke, H. H., Jeong, S. K., & Kleuser, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049427 · Cited by 47
α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin
Ohmatsu, H., Kadono, T., Sugaya, M., Tomita, M., Kai, H., Miyagaki, T., Saeki, H., Tamaki, K., Steeber, D. A., Tedder, T. F., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.048 · Cited by 19
Hong, C.-H., Lin, S.-H., Clausen, B. E., & Lee, C.-H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917479117 · Cited by 17
Self-citationUrocanic Acid: An Endogenous Regulator of Langerhans Cells
Bruhs, A., Eckhart, L., Tschachler, E., Schwarz, T., & Schwarz, A. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.04.016 · Cited by 11
Metadata
- Authors
- Bennett, C. L., van Rijn, E., Jung, S., Inaba, K., Steinman, R. M., Kapsenberg, M. L., & Clausen, B. E.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-05-16
- Volume
- 169
- Issue
- 4
- Pages
- 569-576
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2154137408
- Cited by
- 416
- References
- 0
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
