The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
Open accessAbstract
Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we conducted in situ live cell imaging analysis of LIS1 function throughout the entire radial migration pathway. In utero electroporation of LIS1 small interference RNA and short hairpin dominant negative LIS1 and dynactin cDNAs caused a dramatic accumulation of multipolar progenitor cells within the subventricular zone of embryonic rat brains. This effect resulted from a complete failure in progression from the multipolar to the migratory bipolar state, as revealed by time-lapse analysis of brain slices. Surprisingly, interkinetic nuclear oscillations in the radial glial progenitors were also abolished, as were cell divisions at the ventricular surface. Those few bipolar cells that reached the intermediate zone also exhibited a complete block in somal translocation, although, remarkably, process extension persisted. Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division.
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Cites
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Self-citationNeurons derived from radial glial cells establish radial units in neocortex
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Self-citationIsolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
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Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats
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Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ
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Cited by
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Self-citationMicrotubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
Trekking across the Brain: The Journey of Neuronal Migration
Ayala, R., Shu, T., & Tsai, L.-H. (2007) · Cell · doi:10.1016/j.cell.2006.12.021 · Cited by 620
A new subtype of progenitor cell in the mouse embryonic neocortex
Wang, X., Tsai, J.-W., LaMonica, B., & Kriegstein, A. R. (2011) · Nature Neuroscience · doi:10.1038/nn.2807 · Cited by 507
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Metadata
- Authors
- Tsai, J.-W., Chen, Y., Kriegstein, A. R., & Vallee, R. B.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-09-06
- Volume
- 170
- Issue
- 6
- Pages
- 935-945
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2078564581
- Cited by
- 401
- References
- 45
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- green
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