The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death
Open accessAbstract
The Apaf-1 protein is essential for cytochrome c–mediated caspase-9 activation in the intrinsic mammalian pathway of apoptosis. Although Apaf-1 is the only known mammalian homologue of the Caenorhabditis elegans CED-4 protein, the deficiency of apaf-1 in cells or in mice results in a limited cell survival phenotype, suggesting that alternative mechanisms of caspase activation and apoptosis exist in mammals. In Drosophila melanogaster, the only Apaf-1/CED-4 homologue, ARK, is required for the activation of the caspase-9/CED-3–like caspase DRONC. Using specific mutants that are deficient for ark function, we demonstrate that ARK is essential for most programmed cell death (PCD) during D. melanogaster development, as well as for radiation-induced apoptosis. ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged. These tissues from ark mutant larvae lack detectable PCD. During metamorphosis, larval salivary gland removal was severely delayed in ark mutants. However, PCD occurred normally in the larval midgut, suggesting that ARK-independent cell death pathways also exist in D. melanogaster.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Complete removal of larval salivary glands during D. melanogaster metamorphosis requires both apoptotic and autophagic machinery.
“Along similar lines, the complete removal of larval salivary glands from D. melanogaster larvae undergoing metamorphosis requires the apoptotic as well as the autophagic machinery [830–832].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [831]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works
An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9
Zou, H., Li, Y., Liu, X., & Wang, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11549 · Cited by 2,089 · see citing works
The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis
Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 983 · see citing works
Self-citationWays of dying: multiple pathways to apoptosisPreprint
Adams, J. M. (2003) · Genes & Development · doi:10.1101/gad.1126903 · Cited by 776 · see citing works
Marsden, V. S., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., et al. (2002) · Nature · doi:10.1038/nature01101 · Cited by 578 · see citing works
How death shapes life during development
Baehrecke, E. H. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm931 · Cited by 402 · see citing works
Steroid regulated programmed cell death during Drosophila metamorphosis
Jiang, C., Baehrecke, E. H., & Thummel, C. S. (1997) · Development · doi:10.1242/dev.124.22.4673 · Cited by 392 · see citing works
Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X., & Abrams, J. (1999) · Nature Cell Biology · doi:10.1038/12984 · Cited by 332 · see citing works
DRONC, an ecdysone-inducible Drosophila caspase
Dorstyn, L., Colussi, P. A., Quinn, L. M., Richardson, H. E., & Kumar, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4307 · Cited by 283 · see citing works
Self-citationControl of the Cell Death Pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-Related Caspase Activator
Kanuka, H., Sawamoto, K., Inohara, N., Matsuno, K., Okano, H., & Miura, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80386-x · Cited by 236 · see citing works
Steroid Regulation of Midgut Cell Death during Drosophila Development
Lee, C.-Y., Cooksey, B. A. K., & Baehrecke, E. H. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0784 · Cited by 214 · see citing works
The role of cytochrome c in caspase activation in Drosophila melanogaster cells
Dorstyn, L., Read, S. H., Cakouros, D., Huh, J. R., Hay, B. A., & Kumar, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200111107 · Cited by 204 · see citing works
Self-citationZhou, L., Song, Z., Tittel, J. N., & Steller, H. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80385-8 · Cited by 196 · see citing works
Xu, D., Li, Y., Arcaro, M. J., Lackey, M., & Bergmann, A. (2005) · Development · doi:10.1242/dev.01790 · Cited by 182 · see citing works
Ekert, P. G., Read, S. H., Silke, J., Marsden, V. S., Kaufmann, H., Hawkins, C. J., Gerl, R. E., Kumar, S., & Vaux, D. L. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312031 · Cited by 181 · see citing works
Self-citationThe role of ARK in stress-induced apoptosis in Drosophila cells
Zimmermann, K. C., Ricci, J., Droin, N. M., & Green, D. R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.20112068 · Cited by 175 · see citing works
Mechanisms of steroid-triggered programmed cell death in Drosophila
Yin, V. P., & Thummel, C. S. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.12.007 · Cited by 173 · see citing works
Daish, T. J., Mills, K., & Kumar, S. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.018 · Cited by 171 · see citing works
Self-citationKumar, S., & Doumanis, J. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400756 · Cited by 165 · see citing works
Self-citationAn Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila
Quinn, L. M., Dorstyn, L., Mills, K., Colussi, P. A., Chen, P., Coombe, M., Abrams, J., Kumar, S., & Richardson, H. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002935200 · Cited by 161 · see citing works
Self-citationThe Apical Caspase dronc Governs Programmed and Unprogrammed Cell Death in Drosophila
Chew, S. K., Akdemir, F., Chen, P., Lu, W.-J., Mills, K., Daish, T., Kumar, S., Rodriguez, A., & Abrams, J. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.016 · Cited by 153 · see citing works
Self-citationThree-dimensional Structure of a Double Apoptosome Formed by the Drosophila Apaf-1 Related Killer
Yu, X., Wang, L., Acehan, D., Wang, X., & Akey, C. W. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.10.040 · Cited by 134 · see citing works
Dorstyn, L., Mills, K., Lazebnik, Y. A., & Kumar, S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408054 · Cited by 128 · see citing works
Self-citationCakouros, D., Daish, T., Martin, D. N., Baehrecke, E. H., & Kumar, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201034 · Cited by 99 · see citing works
Self-citationCakouros, D., Daish, T., & Kumar, S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311057 · Cited by 93 · see citing works
Self-citationTranscriptional control of the core cell-death machinery
Kumar, S., & Cakouros, D. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.02.001 · Cited by 70 · see citing works
Self-citationGenetic control of programmed cell death in Drosophila melanogaster
Cashio, P., Lee, T. V., & Bergmann, A. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.01.002 · Cited by 69 · see citing works
Waldhuber, M., Emoto, K., & Petritsch, C. K. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.04.003 · Cited by 67 · see citing works
Mechanism of Dronc activation in Drosophila cells
Muro, I., Monser, K. P., & Clem, R. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01376 · Cited by 67 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationKlionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works
Self-citationOld, new and emerging functions of caspases
Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.216 · Cited by 1,267 · see citing works
Self-citationCaspase function in programmed cell death
Kumar, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402060 · Cited by 863 · see citing works
Self-citationThe CASBAH: a searchable database of caspase substrates
Lüthi, A. U., & Martin, S. J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402103 · Cited by 434 · see citing works
Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila
Denton, D., Shravage, B., Simin, R., Mills, K., Berry, D. L., Baehrecke, E. H., & Kumar, S. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.042 · Cited by 385 · see citing works
Self-citationCell death by autophagy: facts and apparent artefacts
Denton, D., Nicolson, S., & Kumar, S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.146 · Cited by 381 · see citing works
Self-citationApoptosome Structure, Assembly, and Procaspase Activation
Yuan, S., & Akey, C. W. (2013) · Structure · doi:10.1016/j.str.2013.02.024 · Cited by 285 · see citing works
Caspase-Dependent Cell Death inDrosophila
Hay, B. A., & Guo, M. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012804.093845 · Cited by 201 · see citing works
The Life and Death of a Plant Cell
Kabbage, M., Kessens, R., Bartholomay, L. C., & Williams, B. (2017) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043015-111655 · Cited by 157 · see citing works
Muro, I., Berry, D. L., Huh, J. R., Chen, C., Huang, H., Yoo, S. J., Guo, M., Baehrecke, E. H., & Hay, B. A. (2006) · Development · doi:10.1242/dev.02495 · Cited by 150 · see citing works
Genetic control of programmed cell death (apoptosis) in Drosophila
Xu, D., Woodfield, S. E., Lee, T. V., Fan, Y., Antonio, C., & Bergmann, A. (2009) · Fly · doi:10.4161/fly.3.1.7800 · Cited by 127 · see citing works
Role of Mitochondrial Remodeling in Programmed Cell Death in Drosophila melanogaster
Goyal, G., Fell, B., Sarin, A., Youle, R. J., & Sriram, V. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.002 · Cited by 124 · see citing works
Beyond apoptosis: caspase regulatory mechanisms and functions in vivo
Kuranaga, E. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01579.x · Cited by 111 · see citing works
Dual roles of Drosophila p53 in cell death and cell differentiation
Fan, Y., Lee, T. V., Xu, D., Chen, Z., Lamblin, A.-F., Steller, H., & Bergmann, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.182 · Cited by 82 · see citing works
Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila
Denton, D., Chang, T.-K., Nicolson, S., Shravage, B., Simin, R., Baehrecke, E. H., & Kumar, S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2012.43 · Cited by 81 · see citing works
Self-citationMitochondria in energy-limited states: mechanisms that blunt the signaling of cell death
Hand, S. C., & Menze, M. A. (2008) · Journal of Experimental Biology · doi:10.1242/jeb.000299 · Cited by 80 · see citing works
Structure of the Drosophila Apoptosome at 6.9 Å Resolution
Yuan, S., Yu, X., Topf, M., Dorstyn, L., Kumar, S., Ludtke, S. J., & Akey, C. W. (2011) · Structure · doi:10.1016/j.str.2010.10.009 · Cited by 78 · see citing works
Self-citationThe Role of Autophagy in Drosophila Metamorphosis
Tracy, K. M., & Baehrecke, E. H. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385979-2.00004-6 · Cited by 77 · see citing works
Developmentally programmed cell death in Drosophila
Denton, D., Aung-Htut, M. T., & Kumar, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.014 · Cited by 75 · see citing works
Self-citationEcdysone controlled cell and tissue deletion
Xu, T., Jiang, X., Denton, D., & Kumar, S. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0456-9 · Cited by 68 · see citing works
Self-citationThe role of caspases as executioners of apoptosis
Kumar, S., Dorstyn, L., & Lim, Y. P. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210751 · Cited by 70 · see citing works
Self-citation20‐HYDROXYECDYSONE UPREGULATES APOPTOTIC GENES AND INDUCES APOPTOSIS IN THE B OMBYX FAT BODY
Tian, L., Liu, S., Liu, H., & Li, S. (2012) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20457 · Cited by 68 · see citing works
Sevrioukov, E. A., Burr, J., Huang, E. W., Assi, H. H., Monserrate, J. P., Purves, D. C., Wu, J. N., Song, E. J., & Brachmann, C. B. (2007) · genesis · doi:10.1002/dvg.20279 · Cited by 67 · see citing works
Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo
Takemoto, K., Kuranaga, E., Tonoki, A., Nagai, T., Miyawaki, A., & Miura, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702733104 · Cited by 66 · see citing works
A biochemical analysis of the activation of the Drosophila caspase DRONC
Dorstyn, L., & Kumar, S. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402288 · Cited by 61 · see citing works
Self-citationNongenomic action of an insect steroid hormone in steroid-induced programmed cell death
Iga, M., Iwami, M., & Sakurai, S. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.08.005 · Cited by 59 · see citing works
UTX coordinates steroid hormone-mediated autophagy and cell death
Denton, D., Aung-Htut, M. T., Lorensuhewa, N., Nicolson, S., Zhu, W., Mills, K., Cakouros, D., Bergmann, A., & Kumar, S. (2013) · Nature Communications · doi:10.1038/ncomms3916 · Cited by 58 · see citing works
Self-citationLee, T. V., Fan, Y., Wang, S., Srivastava, M., Broemer, M., Meier, P., & Bergmann, A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002261 · Cited by 57 · see citing works
Takeishi, A., Kuranaga, E., Tonoki, A., Misaki, K., Yonemura, S., Kanuka, H., & Miura, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.022 · Cited by 53 · see citing works
A collective form of cell death requires homeodomain interacting protein kinase
Link, N., Chen, P., Lu, W.-J., Pogue, K., Chuong, A. S., Mata, M. A., Checketts, J., & Abrams, J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702125 · Cited by 56 · see citing works
Hippo signalling controls Dronc activity to regulate organ size in Drosophila
Verghese, S., Bedi, S., & Kango‐Singh, M. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.48 · Cited by 52 · see citing works
Liu, H., Jia, Q., Tettamanti, G., & Li, S. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.09.001 · Cited by 48 · see citing works
Lee, G., Wang, Z., Sehgal, R., Chen, C., Kikuno, K., Hay, B. A., & Park, J. H. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22498 · Cited by 46 · see citing works
Steroid-triggered, cell-autonomous death of a Drosophila motoneuron during metamorphosis
Winbush, A., & Weeks, J. C. (2011) · Neural Development · doi:10.1186/1749-8104-6-15 · Cited by 45 · see citing works
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death
Cao, C., Liu, Y., & Lehmann, M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611155 · Cited by 45 · see citing works
A cytochrome c-free fly apoptosome
Dorstyn, L., & Kumar, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401918 · Cited by 43 · see citing works
Self-citationIndrieri, A., Conte, I., Chesi, G., Romano, A., Quartararo, J., Tatè, R., Ghezzi, D., Zeviani, M., Goffrini, P., Ferrero, I., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201739 · Cited by 42 · see citing works
Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched
Kagey, J. D., Brown, J. A., & Moberg, K. H. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.05.007 · Cited by 42 · see citing works
Chapter 2 Methods and Protocols for Studying Cell Death in Drosophila
Denton, D., Mills, K., & Kumar, S. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01602-9 · Cited by 38 · see citing works
Self-citationNosema bombycis (Microsporidia) suppresses apoptosis in BmN cells (Bombyx mori)
He, X., Fu, Z., Li, M., Liu, H., Cai, S., Man, N., & Lu, X. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv062 · Cited by 37 · see citing works
Martin, D. N., Balgley, B. M., Dutta, S., Chen, J., Rudnick, P. A., Cranford, J., Kantartzis, S., DeVoe, D. L., Lee, C., & Baehrecke, E. H. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402098 · Cited by 37 · see citing works
Med24 and Mdh2 are required for Drosophila larval salivary gland cell death
Wang, L., Lam, G., & Thummel, C. S. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22213 · Cited by 35 · see citing works
The multifaceted activity of insect caspases
Accorsi, A., Zibaee, A., & Malagoli, D. (2015) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2015.03.007 · Cited by 30 · see citing works
Cakouros, D., Mills, K., Denton, D., Paterson, A., Daish, T., & Kumar, S. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712169 · Cited by 29 · see citing works
Self-citationA Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation
Cheng, T. C., Akey, I. V., Yuan, S., Yu, Z., Ludtke, S. J., & Akey, C. W. (2016) · Structure · doi:10.1016/j.str.2016.11.002 · Cited by 29 · see citing works
Ward, K. N., Coleman, J. L., Clinnin, K., Fahrbach, S. E., & Rueppell, O. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.012 · Cited by 28 · see citing works
Lee, G., Sehgal, R., Wang, Z., Nair, S., Kikuno, K., Chen, C., Hay, B. A., & Park, J. H. (2013) · Biology Open · doi:10.1242/bio.20133384 · Cited by 27 · see citing works
Woodfield, S. E., Graves, H. K., Hernandez, J., & Bergmann, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056021 · Cited by 26 · see citing works
Katoh, I., Sato, S., Fukunishi, N., Yoshida, H., Imai, T., & Kurata, S. (2008) · Cell Research · doi:10.1038/cr.2008.87 · Cited by 23 · see citing works
A Genomic Response to the Yeast Transcription Factor GAL4 in Drosophila
Liu, Y., & Lehmann, M. (2008) · Fly · doi:10.4161/fly.6311 · Cited by 23 · see citing works
A steroid-controlled global switch in sensitivity to apoptosis during Drosophila development
Kang, Y., & Bashirullah, A. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.12.005 · Cited by 22 · see citing works
Steroid Hormone Control of Cell Death and Cell Survival: Molecular Insights Using RNAi
Chittaranjan, S., McConechy, M. M., Hou, Y. C., Freeman, J., DeVorkin, L., & Gorski, S. M. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000379 · Cited by 21 · see citing works
Control of apoptosis by Drosophila DCAF12
Hwangbo, D., Biteau, B., Rath, S. P., Kim, J., & Jasper, H. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.03.003 · Cited by 20 · see citing works
The Power of Drosophila Genetics: The Discovery of the Hippo Pathway
Gokhale, R. H., & Pfleger, C. M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8910-2_1 · Cited by 19 · see citing works
Self-citationMa, H., Yan, X., Yan, L., Zhao, J., Song, J., Peng, R., Yang, Y., Peng, J., & Liu, K. (2021) · Insects · doi:10.3390/insects12010064 · Cited by 14 · see citing works
Interactions of DNR1 with the apoptotic machinery of<i>Drosophila</i>melanogaster
Primrose, D. A., Chaudhry, S., Johnson, A. G. D., Hrdlicka, A., Schindler, A., Tran, D., & Foley, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03417 · Cited by 15 · see citing works
Studying Apoptosis in DrosophilaPreprint
Denton, D., & Kumar, S. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top070433 · Cited by 13 · see citing works
Self-citationZou, S., Luo, Y., Jin, Y., Jing, W., Huang, Y., Liang, Y., Li, Y., Hao, Z., Xu, Y., & Wang, H. (2025) · Advanced Science · doi:10.1002/advs.202504664 · Cited by 6 · see citing works
Braun, T., Afgin, N., Sapozhnikov, L., Sivan, E., Bergmann, A., Baena-López, L. A., Yacobi-Sharon, K., & Arama, E. (2025) · Nature Communications · doi:10.1038/s41467-025-65996-2 · Cited by 4 · see citing works
ZHANG, L. J., Huang, J., Feng, C. H. E. N., Zhen Yang, Y. U., Wu, Z. L., & Wu, G. (2014) · European Journal of Entomology · doi:10.14411/eje.2014.064 · Cited by 3 · see citing works
Apoptosis: the intrinsic pathway
White, J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.032 · Cited by 3 · see citing works
Cortacans, M., & Cardona, P.-J. (2025) · Frontiers in Tuberculosis · doi:10.3389/ftubr.2025.1735950 · Cited by 2 · see citing works
The I.3.2 developmental mutant has a single nucleotide deletion in the gene centromere identifier
Evans, C. J., Bieser, K. L., Acevedo-Vasquez, K. S., Augustine, E. J., Bowen, S., Casarez, V. A., Feliciano, V. I., Glazier, A., Guinan, H. R., Hallman, R., et al. (2022) · PubMed Central · doi:10.17912/micropub.biology.000653 · Cited by 1 · see citing works
Indrieri, A. (2010) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/8451
EUROPEAN SCHOOL OF MOLECULAR MEDICINE
Napoli, S. D. (2010)
Thomson, L., Shah, H. P., Adewale, V. A., Beise, A., Bliayang, C., Cioch, Z., Craig, M., Crump, A., Durdan, M., Espinosa, M., et al. (2023) · PubMed Central · doi:10.17912/micropub.biology.001019
Hippo pathway perturbation disrupts cell fate control in the Drosophila eyePreprint
Hilmi, A. J. S., Manning, S. A., Dent, L., Mitchell, K. A., & Harvey, K. F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.08.723765
Self-citationA Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation
Chang, T.-K. (2013) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m20s36
- Authors
- Mills, K., Daish, T., Harvey, K. F., Pfleger, C. M., Hariharan, I. K., & Kumar, S.
- Affiliations
- South Australia Pathology (AU)
- University of California, Berkeley (US)
- Corresponding author
- Kumar, Sharad
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-03-13
- Volume
- 172
- Issue
- 6
- Pages
- 809-815
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2063725
- OpenAlex
- W2109370225
- Cited by
- 70
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 11 · 2012: 6
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-sa)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- ark, programmed cell death, apoptosis, caspase-9 activation, Dronc, CED-4, Drosophila melanogaster, radiation-induced apoptosis, metamorphosis, salivary gland removal, larval midgut, alternative cell death pathways, developmental cell death
- MeSH terms
- Animals, Drosophila melanogaster, Embryo, Nonmammalian, Genes, Lethal, Larva, Metamorphosis, Biological, Mutation, Radiation, Ionizing, Salivary Glands, Signal Transduction, Apoptosis, Gene Expression Regulation, Developmental, Evolution, Molecular, Drosophila Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
