Developmentally programmed cell death in Drosophila

Denton, Donna; Aung-Htut, May T.; Kumar, Sharad

doi:10.1016/j.bbamcr.2013.06.014

Cited by 75Cell death mechanisms and regulationNeurobiology and Insect Physiology ResearchDevelopmental Biology and Gene Regulation

Developmentally programmed cell death in Drosophila

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Denton, Donna, Aung-Htut, May T., Kumar, Sharad·2013·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2013.06.014

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Abstract

During the development of metazoans, programmed cell death (PCD) is essential for tissue patterning, removal of unwanted cells and maintaining homeostasis. In the past 20 years Drosophila melanogaster has been one of the systems of choice for studies involving developmental cell death, providing an ideal genetically tractable model of intermediary complexity between Caenorhabditis elegans and mammals. The lessons learned from studies using Drosophila indicate both the conserved nature of the many cell death pathways as well as novel and unexpected mechanisms. In this article we review the understanding of PCD during Drosophila development, highlighting the key mechanisms that are evolutionarily conserved as well as apparently unusual pathways, which indicate divergence, but provide evidence of complexity acquired during organismic evolution. This article is part of a Special Section entitled: Cell Death Pathways.

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The major players of the apoptotic pathway are largely conserved between mammals and Drosophila and C. elegans.
“The details of the apoptotic pathway differ between mammals and the model organisms Drosophila and C. elegans, however the major players are largely conserved (Figure 1).”
From Programmed cell death in aging (2015) · cites this paper as Denton et al., 2013

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Authors: Denton, D., Aung-Htut, M. T., & Kumar, S.
Affiliations: South Australia Pathology (AU)
Corresponding author: Kumar, Sharad
ORCID: Denton, Donna
Aung-Htut, May T.
Kumar, Sharad
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2013-12
Volume: 1833
Issue: 12
Pages: 3499-3506
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2013.06.014
OpenAlex: W1990775733
Cited by: 75
References: 153
Citations by year: 2026: 1 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 6
FWCI: 0.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: National Health and Medical Research Council (NHMRC) (626903, 1041807)
Senior Principal Research Fellowship (1002863)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: programmed cell death, Drosophila melanogaster, developmental cell death, cell death pathways, tissue patterning
MeSH terms: Animals, Drosophila melanogaster, Metamorphosis, Biological, Models, Biological, Signal Transduction, Apoptosis, Drosophila Proteins

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Developmentally programmed cell death in Drosophila

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