Drosophila Caspase DRONC Is Required for Specific Developmental Cell Death Pathways and Stress-Induced Apoptosis
Open accessAbstract
Proteases of the caspase family play key roles in the execution of apoptosis. In Drosophila there are seven caspases, but their roles in cell death have not been studied in detail due to a lack of availability of specific mutants. Here, we describe the generation of a specific mutant of the Drosophila gene encoding DRONC, the only caspase recruitment domain (CARD) containing apical caspase in the fly. dronc mutants are pupal lethal and our studies show that DRONC is required for many forms of developmental cell deaths and apoptosis induced by DNA damage. Furthermore, we demonstrate that DRONC is required for the autophagic death of larval salivary glands during metamorphosis, but not for histolysis of larval midguts. Our results indicate that DRONC is involved in specific developmental cell death pathways and that in some tissues, effector caspase activation and cell death can occur independently of DRONC.
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Complete removal of larval salivary glands during D. melanogaster metamorphosis requires both apoptotic and autophagic machinery.
“Along similar lines, the complete removal of larval salivary glands from D. melanogaster larvae undergoing metamorphosis requires the apoptotic as well as the autophagic machinery [830–832].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [832]
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Self-citationKale, A., Li, W., Lee, C.-H., & Baker, N. E. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.218 · Cited by 49 · see citing works
Liu, H., Jia, Q., Tettamanti, G., & Li, S. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.09.001 · Cited by 48 · see citing works
Lee, G., Wang, Z., Sehgal, R., Chen, C., Kikuno, K., Hay, B. A., & Park, J. H. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22498 · Cited by 46 · see citing works
Steroid-triggered, cell-autonomous death of a Drosophila motoneuron during metamorphosis
Winbush, A., & Weeks, J. C. (2011) · Neural Development · doi:10.1186/1749-8104-6-15 · Cited by 45 · see citing works
Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc
Yan, N., Huh, J. R., Schirf, V. R., Demeler, B., Hay, B. A., & Shi, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513232200 · Cited by 45 · see citing works
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death
Cao, C., Liu, Y., & Lehmann, M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611155 · Cited by 45 · see citing works
The role of ubiquitylation for the control of cell death in Drosophila
Bergmann, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.70 · Cited by 44 · see citing works
SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda
Huang, N., Civciristov, S., Hawkins, C. J., & Clem, R. J. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.02.005 · Cited by 41 · see citing works
Edwards, C. H., Christie, C. R., Masotti, A., Celluzzi, A., Caporali, A., & Campbell, E. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69068-x · Cited by 40 · see citing works
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Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes
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Chapter 2 Methods and Protocols for Studying Cell Death in Drosophila
Denton, D., Mills, K., & Kumar, S. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01602-9 · Cited by 38 · see citing works
Self-citationMale-Killing Spiroplasma Induces Sex-Specific Cell Death via Host Apoptotic Pathway
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Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila
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Noncanonical cell death pathways act during Drosophila oogenesis
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Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity
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- Authors
- Daish, T. J., Mills, K., & Kumar, S.
- Affiliations
- South Australia Pathology (AU)
- Corresponding author
- Kumar, Sharad
- ORCID
- Kumar, Sharad
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 7
- Issue
- 6
- Pages
- 909-915
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2014844816
- Cited by
- 171
- References
- 23
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 12 · 2012: 11
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3150 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- Dronc, caspases, apoptosis, developmental cell death, caspase recruitment domain, DNA damage-induced apoptosis, autophagic cell death, salivary glands, metamorphosis, histolysis, midgut, pupal lethality, Drosophila
- MeSH terms
- Animals, Cell Line, Crosses, Genetic, DNA Damage, Drosophila melanogaster, Immunohistochemistry, Larva, Models, Biological, Mutation, Phenotype, RNA, Messenger, Salivary Glands, Time Factors, Immunoblotting, Cell Death, Apoptosis, Protein Structure, Tertiary, Gene Expression Regulation, Developmental, Transgenes, Caspases, In Situ Nick-End Labeling, Drosophila Proteins, Animals, Genetically Modified
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