The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
Open accessAbstract
The physiological role of the mitotic checkpoint protein Bub1 is unknown. To study this role, we generated a series of mutant mice with a gradient of reduced Bub1 expression using wild-type, hypomorphic, and knockout alleles. Bub1 hypomorphic mice are viable, fertile, and overtly normal despite weakened mitotic checkpoint activity and high percentages of aneuploid cells. Bub1 haploinsufficient mice, which have a milder reduction in Bub1 protein than Bub1 hypomorphic mice, also exhibit reduced checkpoint activity and increased aneuploidy, but to a lesser extent. Although cells from Bub1 hypomorphic and haploinsufficient mice have similar rates of chromosome missegregation, cell death after an aberrant separation decreases dramatically with declining Bub1 levels. Importantly, Bub1 hypomorphic mice are highly susceptible to spontaneous tumors, whereas Bub1 haploinsufficient mice are not. These findings demonstrate that loss of Bub1 below a critical threshold drives spontaneous tumorigenesis and suggest that in addition to ensuring proper chromosome segregation, Bub1 is important for mediating cell death when chromosomes missegregate.
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Cites
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
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The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227
The anaphase promoting complex/cyclosome: a machine designed to destroy
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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731
Self-citationThe Mad2 spindle checkpoint protein has two distinct natively folded states
Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., & Yu, H. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb748 · Cited by 297
Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice
Baker, D. J., Jeganathan, K. B., Malureanu, L., Perez-Terzic, C., Terzic, A., & van Deursen, J. M. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200507081 · Cited by 175
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Cited by
Cell cycle, CDKs and cancer: a changing paradigm
Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
Thompson, S. L., & Compton, D. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200905057 · Cited by 494
Bolton, H., Graham, S. J. L., Van der Aa, N., Kumar, P., Theunis, K., Fernandez Gallardo, E., Voet, T., & Zernicka-Goetz, M. (2016) · Nature Communications · doi:10.1038/ncomms11165 · Cited by 451
Mitotic chromosomal instability and cancer: mouse modelling of the human disease
Schvartzman, J.-M., Sotillo, R., & Benezra, R. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2781 · Cited by 414
Metadata
- Authors
- Jeganathan, K., Malureanu, L., Baker, D. J., Abraham, S. C., & van Deursen, J. M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-10-15
- Volume
- 179
- Issue
- 2
- Pages
- 255-267
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2139682891
- Cited by
- 221
- References
- 7
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Jeganathan, K., Malureanu, L., Baker, D. J., Abraham, S. C., & van Deursen, J. M. (2007). Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200706015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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