The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling
Open accessAbstract
Postsynaptic density 95 (PSD-95) is an important regulator of synaptic structure and plasticity. However, its contribution to synapse formation and organization remains unclear. Using a combined electron microscopic, genetic, and pharmacological approach, we uncover a new mechanism through which PSD-95 regulates synaptogenesis. We find that PSD-95 overexpression affected spine morphology but also promoted the formation of multiinnervated spines (MISs) contacted by up to seven presynaptic terminals. The formation of multiple contacts was specifically prevented by deletion of the PDZ2 domain of PSD-95, which interacts with nitric oxide (NO) synthase (NOS). Similarly, PSD-95 overexpression combined with small interfering RNA–mediated down-regulation or the pharmacological blockade of NOS prevented axon differentiation into varicosities and multisynapse formation. Conversely, treatment of hippocampal slices with an NO donor or cyclic guanosine monophosphate analogue induced MISs. NOS blockade also reduced spine and synapse density in developing hippocampal cultures. These results indicate that the postsynaptic site, through an NOS–PSD-95 interaction and NO signaling, promotes synapse formation with nearby axons.
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Cites
Structural basis of long-term potentiation in single dendritic spines
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PSD-95 Involvement in Maturation of Excitatory Synapses
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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
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Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
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The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
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Synapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579
Spine growth precedes synapse formation in the adult neocortex in vivo
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Self-citationPSD-95 is required for activity-driven synapse stabilization.
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Cited by
Dendritic Spines: The Locus of Structural and Functional Plasticity
Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
Cheng, A., Wan, R., Yang, J.-L., Kamimura, N., Son, T. G., Ouyang, X., Luo, Y., Okun, E., & Mattson, M. P. (2012) · Nature Communications · doi:10.1038/ncomms2238 · Cited by 401
Balance and Stability of Synaptic Structures during Synaptic Plasticity
Meyer, D., Bonhoeffer, T., & Scheuss, V. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.031 · Cited by 395
Muddashetty, R. S., Nalavadi, V. C., Gross, C., Yao, X., Xing, L., Laur, O., Warren, S. T., & Bassell, G. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.006 · Cited by 364
Dendritic spine formation and stabilization
Yoshihara, Y., De Roo, M., & Muller, D. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.013 · Cited by 292
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Metadata
- Authors
- Nikonenko, I., Boda, B., Steen, S., Knott, G., Welker, E., & Muller, D.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2008-12-15
- Volume
- 183
- Issue
- 6
- Pages
- 1115-1127
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2138747960
- Cited by
- 178
- References
- 11
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nikonenko, I., Boda, B., Steen, S., Knott, G., Welker, E., & Muller, D. (2008). PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200805132
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