Balance and Stability of Synaptic Structures during Synaptic Plasticity
Open accessAbstract
Subsynaptic structures such as bouton, active zone, postsynaptic density (PSD) and dendritic spine, are highly correlated in their dimensions and also correlate with synapse strength. Why this is so and how such correlations are maintained during synaptic plasticity remains poorly understood. We induced spine enlargement by two-photon glutamate uncaging and examined the relationship between spine, PSD, and bouton size by two-photon time-lapse imaging and electron microscopy. In enlarged spines the PSD-associated protein Homer1c increased rapidly, whereas the PSD protein PSD-95 increased with a delay and only in cases of persistent spine enlargement. In the case of nonpersistent spine enlargement, the PSD proteins remained unchanged or returned to their original level. The ultrastructure at persistently enlarged spines displayed matching dimensions of spine, PSD, and bouton, indicating their correlated enlargement. This supports a model in which balancing of synaptic structures is a hallmark for the stabilization of structural modifications during synaptic plasticity.
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LTP is associated with a long-lasting increase in spine size, including a late increase in the size of the PSD and a slow increase in the size of the presynaptic bouton.
“LTP is associated with a long-lasting increase in spine size (247, 248), including a late increase in the size of the PSD (56, 213, 414, 415) and additionally a slow increase in the size of the presynaptic bouton (213, 414).”
From Synaptic memory and CaMKII (2023) · cites this paper as [213]
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- Authors
- Meyer, D., Bonhoeffer, T., & Scheuss, V.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- Max Planck Society (DE)
- Corresponding author
- Bonhoeffer, Tobias
- Scheuss, Volker
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 82
- Issue
- 2
- Pages
- 430-443
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2016756702
- Cited by
- 395
- References
- 10
- Citations by year
- 2026: 9 · 2025: 26 · 2024: 21 · 2023: 37 · 2022: 33 · 2021: 41 · 2020: 49 · 2019: 38 · 2018: 32 · 2017: 43 · 2016: 27 · 2015: 26 · 2014: 13
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-06-04)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synaptic plasticity, postsynaptic density, PSD-95, glutamate uncaging, spinal stabilization
- MeSH terms
- Homer Scaffolding Proteins, Disks Large Homolog 4 Protein, Animals, Animals, Newborn, Carrier Proteins, Membrane Proteins, Neuronal Plasticity, Neurons, Organ Culture Techniques, Synapses, Time Factors, Transduction, Genetic, Rats, Wistar, Glutamic Acid, Plant Lectins, Intracellular Signaling Peptides and Proteins, Dendritic Spines, Green Fluorescent Proteins, Rats, CA1 Region, Hippocampal, Post-Synaptic Density
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