Synapse formation on neurons born in the adult hippocampus
Abstract
Although new and functional neurons are produced in the adult brain, little is known about how they integrate into mature networks. Here we explored the mechanisms of synaptogenesis on neurons born in the adult mouse hippocampus using confocal microscopy, electron microscopy and live imaging. We report that new neurons, similar to mature granule neurons, were contacted by axosomatic, axodendritic and axospinous synapses. Consistent with their putative role in synaptogenesis, dendritic filopodia were more abundant during the early stages of maturation and, when analyzed in three dimensions, the tips of all filopodia were found within 200 nm of preexisting boutons that already synapsed on other neurons. Furthermore, dendritic spines primarily synapsed on multiple-synapse boutons, suggesting that initial contacts were preferentially made with preexisting boutons already involved in a synapse. The connectivity of new neurons continued to change until at least 2 months, long after the formation of the first dendritic protrusions.
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An aberrant increase in the generation of newborn neurons increases the competition for afferent inputs.
“increase the competition for afferent inputs33”
From Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression (2017) · cites this paper as [33]
New extensions connect to existing neurons, creating new synapses (synaptogenesis).
“These new extensions will connect to existing neurons, creating new synapses (synaptogenesis) [168].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [168]
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- Authors
- Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of California San Diego (US)
- Corresponding author
- Gage, Fred H
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2007-05-07
- Volume
- 10
- Issue
- 6
- Pages
- 727-734
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2061111257
- Cited by
- 579
- References
- 50
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 17 · 2023: 16 · 2022: 11 · 2021: 21 · 2020: 32 · 2019: 29 · 2018: 30 · 2017: 35 · 2016: 31 · 2015: 31 · 2014: 40 · 2013: 43 · 2012: 30
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (RRP41-04050)
- National Institute of Neurological Disorders and Stroke (R01NS050217, NS050217-02)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult neurogenesis, synaptogenesis, hippocampus, granule neurons, dendritic filopodia, dendritic spines, axospinous synapses, axodendritic synapses, axosomatic synapses, synapse maturation, neuronal connectivity
- MeSH terms
- Animals, Diagnostic Imaging, Female, Hippocampus, Mice, Inbred C57BL, Models, Neurological, Synaptic Transmission, Neurons, Synapses, Presynaptic Terminals, Microscopy, Confocal, Organogenesis, Microscopy, Electron, Transmission, Dendritic Spines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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