The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
Open accessAbstract
Epithelial paracellular barrier function, determined primarily by tight junction permeability, is frequently disrupted in disease. In the intestine, barrier loss can be mediated by tumor necrosis factor (α) (TNF) signaling and epithelial myosin light chain kinase (MLCK) activation. However, TNF induces only limited alteration of tight junction morphology, and the events that couple structural reorganization to barrier regulation have not been defined. We have used in vivo imaging and transgenic mice expressing fluorescent-tagged occludin and ZO-1 fusion proteins to link occludin endocytosis to TNF-induced tight junction regulation. This endocytosis requires caveolin-1 and is essential for structural and functional tight junction regulation. These data demonstrate that MLCK activation triggers caveolin-1–dependent endocytosis of occludin to effect structural and functional tight junction regulation.
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Cites
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
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Dynasore, a Cell-Permeable Inhibitor of Dynamin
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Pathways of clathrin-independent endocytosis
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The multiple faces of caveolae
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Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
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Cited by
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature Reviews Immunology · doi:10.1038/nri3608 · Cited by 3,173
Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
Chelakkot, C., Ghim, J., & Ryu, S. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0126-x · Cited by 2,017
The intestinal epithelial barrier: a therapeutic target?
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Self-citationFunctional morphology of the blood–brain barrier in health and disease
Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872
Tight Junction Pore and Leak Pathways: A Dynamic Duo
Shen, L., Weber, C. R., Raleigh, D. R., Yu, D., & Turner, J. R. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142150 · Cited by 872
Self-citation
Metadata
- Authors
- Marchiando, A. M., Shen, L., Graham, W. V., Weber, C. R., Schwarz, B. T., Austin, J. R., Raleigh, D. R., Guan, Y., Watson, A. J. M., Montrose, M. H., & Turner, J. R.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-03-29
- Volume
- 189
- Issue
- 1
- Pages
- 111-126
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2142613038
- Cited by
- 477
- References
- 76
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Marchiando, A. M., Shen, L., Graham, W. V., Weber, C. R., Schwarz, B. T., Austin, J. R., Raleigh, D. R., Guan, Y., Watson, A. J. M., Montrose, M. H., & Turner, J. R. (2010). Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. Journal of Cell Biology. https://doi.org/10.1083/jcb.200902153
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