Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

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2. Mechanisms of disease: inflammasome activation and the development of type 2 diabetes
   Ryan W. Grant, Vishwa Deep Dixit · 2013 · Frontiers in Immunology
3. Diabetes Medications: Impact on Inflammation and Wound Healing
   J. J. Salazar, W. Ennis, T. Koh · 2015 · Journal of diabetes and its complications
4. NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?
   Bordt, Evan A., Polster, Brian M. · 2014 · Free Radical Biology and Medicine
5. HIV-1 tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation.
   Chivero, Ernest T., Guo, Ming-Lei, Periyasamy, Palsamy, Liao, Ke, Callen, Shannon E., Buch, Shilpa · 2017 · The Journal of Neuroscience
6. Propionibacterium acnes Induces IL-1β Secretion via the NLRP3 Inflammasome in Human Monocytes
   Min Qin, Aslan Pirouz, Myung‐Hwa Kim, Stephan R. Krutzik, Hermes Garbán, Jenny J Kim · 2013 · Journal of Investigative Dermatology
7. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
   Xabier Unamuno, Javier Gómez‐Ambrosi, Beatriz Ramírez, Amaia Rodrı́guez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck et al. · 2019 · Cellular and Molecular Immunology
8. Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
   Cong‐Fei Xu, Zi-Dong Lu, Ying‐Li Luo, Yang Liu, Zhiting Cao, Song Shen, Hongjun Li, Jing Liu, Kaige Chen, Zhiyao Chen et al. · 2018 · Nature Communications
9. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice
   Isis Ludwig‐Portugall, Eva Bartok, Ermanila Dhana, Beatrix D.G. Evers, Michael J. Primiano, J. Perry Hall, Bernardo S. Franklin, Percy Alexander Knolle, Veit Hornung, Gunther Hartmann et al. · 2016 · Kidney International
10. Lung inflammation caused by inhaled toxicants: A review
    Wong, John, Magun, Bruce, Wood, Lisa · 2016 · International Journal of Chronic Obstructive Pulmonary Disease
11. Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family
    Cees J. Tack, Rinke Stienstra, Leo A. B. Joosten, Mihai Gheorghe Netea · 2012 · Immunological Reviews
12. The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia
    Jie Liao, Vishal Kapadia, Larry Steven Brown, Naeun Cheong, Christopher Longoria, Dan Mija, Mrithyunjay Ramgopal, Julie Mirpuri, Donald McCurnin, Rashmin C. Savani · 2015 · Nature Communications
13. Updated insights into the molecular networks for NLRP3 inflammasome activation
    Seungwha Paik, Jin Kyung Kim, Hyo Jung Shin, Eunjin Park, In Soo Kim, Eun‐Kyeong Jo · 2025 · Cellular and Molecular Immunology
14. IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction
    Clara Y. Westwell-Roper, Derek L. Dai, Galina Soukhatcheva, Kathryn J. Potter, Nico van Rooijen, Jan A. Ehses, C. Bruce Verchere · 2011 · The Journal of Immunology
15. The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans
    Ling Liu, Ying Dong, Mei Ye, Shi Kun Jin, Jianbo Yang, Maria E. Joosse, Yu Sun, Jennifer Zhang, Mark G. Lazarev, Steven R. Brant et al. · 2016 · Journal of Crohn s and Colitis
16. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
    Xiaoyan Zhan, Qiang Li, Guang Xu, Xiaohe Xiao, Zhaofang Bai · 2023 · Frontiers in Immunology
17. Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation
    Hanne Van Gorp, Pedro H. V. Saavedra, Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Lieselotte Vande Walle, Magdalena Matusiak, Giusi Prencipe, Antonella Insalaco, Filip Van Hauwermeiren, Dieter Demon et al. · 2016 · Proceedings of the National Academy of Sciences
18. Fatty acid oxidation contributes to IL-1β secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration
    Qi Zhang, Herui Wang, Chengyuan Mao, Mitchell Sun, Gifty A. Dominah, Li‐Yuan Chen, Zhengping Zhuang · 2017 · Molecular Immunology
19. Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
    Adelin Gustot, José Ignacio Gallea, Rabia Sarroukh, M. Soledad Celej, Jean‐Marie Ruysschaert, Vincent Raussens · 2015 · Biochemical Journal
20. Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
    Lian Wang, Yanghui Zhu, Lu Zhang, Linghong Guo, Xiaoyun Wang, Zhaoping Pan, Xian Li Jiang, Fengbo Wu, Gu He · 2023 · Cell Death and Disease
21. Inflammasomes contributing to inflammation in arthritis
    Lotte Spel, Fabio Martinon · 2020 · Immunological Reviews
22. Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
    Michael J. Primiano, Bruce A. Lefker, Michael R. Bowman, Andrea G. Bree, Cédric Hubeau, Paul D. Bonin, Matthew Mangan, Ken Dower, Brian G. Monks, Leah Cushing et al. · 2016 · The Journal of Immunology
23. Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation
    Tomasz Próchnicki, Matthew Mangan, Eicke Latz · 2016 · F1000Research
24. Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage
    Yun‐Hee Youm, Ayinuer Adijiang, Bolormaa Vandanmagsar, David H. Burk, Anthony Ravussin, Vishwa Deep Dixit · 2011 · Endocrinology
25. The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
    Youm, Yun-Hee, Kanneganti, Thirumala-Devi, Vandanmagsar, Bolormaa, Zhu, Xuewei, Ravussin, Anthony, Adijiang, Ayinuer, Owen, John S., Thomas, Michael J., Francis, Joseph, Parks, John S. et al. · 2012 · Cell Reports
26. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
    Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. V. Saavedra, Petr Šimon, Vladimír Šubr et al. · 2019 · PLoS Biology
27. The Inflammasome in Atherosclerosis and Type 2 Diabetes
    Masters, Seth L., Latz, Eicke, O’Neill, Luke A. J. · 2011 · Science Translational Medicine
28. Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19
    Adnan Shah · 2020 · Frontiers in Immunology
29. Targeting the NLRP3 inflammasome for inflammatory disease therapy
    Julia Elise Cabral, Anna Wu, Haitian Zhou, Minh Anh Pham, Sophia Lin, Reginald McNulty · 2025 · Trends in Pharmacological Sciences
30. Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts
    Manmeet K. Mamik, C. Power · 2017 · Brain : a journal of neurology
31. Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review
    Danbin Wu, Yefei Chen, Yingxin Sun, Qing Gao, Huhu Li, Zhengfei Yang, Yangxue Wang, Xijuan Jiang, Bin Yu · 2019 · Inflammation
32. The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
    Jeremy A. Hirota, Simon Andrew Hirota, Stephanie Warner, Dorota Stefanowicz, Furquan Shaheen, Paul L. Beck, Justin A. MacDonald, Tillie‐Louise Hackett, Don D. Sin, Stephan F. van Eeden et al. · 2012 · Journal of Allergy and Clinical Immunology
33. The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors
    Francesco Di Virgilio · 2013 · Pharmacological Reviews
34. The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
    Ni Zhao, Bin Di, Lili Xu · 2021 · Cytokine & Growth Factor Reviews
35. TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy
    Nagaraj Kerur, Yoshio Hirano, Valeria Tarallo, Benjamin J. Fowler, Ana Bastos-Carvalho, Tetsuhiro R. Yasuma, Reo Yasuma, Younghee Kim, David R. Hinton, Carsten J. Kirschning et al. · 2013 · Investigative Ophthalmology & Visual Science
36. Pyroptosis and pyroptosis-inducing cancer drugs
    Fan Yang, Sahana Bettadapura, Mark S. Smeltzer, Hua Zhu C, Shanzhi Wang · 2022 · Acta Pharmacologica Sinica
37. Deregulated inflammasome signaling in disease
    Mohamed Lamkanfi, Lieselotte Vande Walle, Thirumala‐Devi Kanneganti · 2011 · Immunological Reviews
38. Pathophysiologic Response to Burns in the Elderly
    Marc G. Jeschke, David Patsouris, Mile Stanojcic, Abdikarim Abdullahi, Sarah Rehou, Ruxandra L Pinto, Peter Chen, Marjorie Burnett, Saeid Amini‐Nik · 2015 · EBioMedicine
39. Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease
    Sima Kianpour Rad, Aditya Arya, Hamed Karimian, Priya Madhavan, Farzana Rizwan, Shajan Koshy, Girish Prabhu · 2018 · Drug Design Development and Therapy
40. Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome
    Nathan A. Bracey, Benjamin Gershkovich, Justin Chun, Akosua Vilaysane, H. Christopher Meijndert, James R. Wright, Paul W.M. Fedak, Paul L. Beck, Daniel A. Muruve, Henry J. Duff · 2014 · Journal of Biological Chemistry
41. NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass
    Lei Hou, Zhongwei Yang, Zhankui Wang, Xiao Zhang, Yanhua Zhao, Hao Yang, Beijie Zheng, Weitian Tian, Shao-Cheng Wang, Zhengyu He et al. · 2018 · Laboratory Investigation
42. Inflammasomes, the eye and anti-inflammasome therapy
    Praveen Yerramothu, Ajay Kumar Vijay, Mark D. P. Willcox · 2017 · Eye
43. Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
    Israr Ahmad, Kashiff M. Muneer, Iman A. Tamimi, Michelle E. Chang, Muhammad O. Ata, Nabiha Yusuf · 2013 · Toxicology and Applied Pharmacology
44. Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases
    Xiangna Zhang, Ana Xu, Jiahui Lv, Qiuqiong Zhang, Yingying Ran, Chao Wei, Jingde Wu · 2019 · European Journal of Medicinal Chemistry
45. Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90
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46. NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
    Ilona M. Góra, Anna Ciechanowska, Piotr Ładyżyński · 2021 · Cells
47. IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies
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48. Innate immune activation in obesity
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49. Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance
    Brandyn D. Henriksbo, Trevor C. Lau, Joseph F. Cavallari, Emmanuel Denou, Wendy Chi, James Lally, Justin D. Crane, Brittany M. Duggan, Kevin P. Foley, Morgan D. Fullerton et al. · 2014 · Diabetes
50. Inhibiting the Inflammasome: A Chemical Perspective
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51. Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys
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52. Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes
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53. Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases
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54. NLRP3 inflammasome in neurodegenerative disease
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55. New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
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56. The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
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57. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
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58. Mechanisms of unconventional secretion of IL-1 family cytokines
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59. Biochemical regulation of the inflammasome
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60. NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes
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61. Inflammasomes: sensors of metabolic stresses for vascular inflammation
    Yang, Xiao-feng · 2013 · Frontiers in Bioscience
62. The Immune System and the Role of Inflammation in Perinatal Depression
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63. Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome
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64. Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases
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65. Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia
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66. Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children
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67. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome
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68. Unsolved Mysteries in NLR Biology
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69. The bizarre pharmacology of the ATP release channel pannexin1
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70. NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia–Reperfusion Injury Independently of Inflammasomes
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71. NLRP3 Inflammasome in Acute Myocardial Infarction
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72. NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production
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73. NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development
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74. Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?
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75. Oxalate, inflammasome, and progression of kidney disease
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76. The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment
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77. SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway
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78. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke
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79. Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities
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80. Principles of inflammasome priming and inhibition: implications for psychiatric disorders
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81. Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases
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82. NLRP3 (Nucleotide Oligomerization Domain–Like Receptor Family, Pyrin Domain Containing 3)–Caspase-1 Inflammasome Degrades Contractile Proteins
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83. Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
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84. NLRP inflammasomes in health and disease
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85. Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis
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86. Induction of MicroRNA-21 With Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice
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87. Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling
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88. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro- N -[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis
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89. Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study
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90. Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
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91. Zinc depletion regulates the processing and secretion of IL-1β
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92. Acquired immunodeficiencies and tuberculosis: focus on HIV / AIDS and diabetes mellitus
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93. Pannexin: From discovery to bedside in 11±4 years?
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94. Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases
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95. Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review
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96. Inflammasomes in wound healing and fibrosis
    Carol M. Artlett · 2012 · The Journal of Pathology
97. Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets
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98. Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis
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99. Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux
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100. Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition
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