The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Targeting of drugs and nanoparticles to tumors
Open accessAbstract
The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as docking sites to concentrate drug conjugates and nanoparticles at tumors. Specific markers in tumor vessels are particularly well suited for targeting because molecules at the surface of blood vessels are readily accessible to circulating compounds. The increased concentration of a drug in the site of disease made possible by targeted delivery can be used to increase efficacy, reduce side effects, or achieve some of both. We review the recent advances in this delivery approach with a focus on the use of molecular markers of tumor vasculature as the primary target and nanoparticles as the delivery vehicle.
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Cites
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C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
Teesalu, T., Sugahara, K. N., Kotamraju, V. R., & Ruoslahti, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908201106 · Cited by 812
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Cited by
Hallmarks of Cancer: The Next Generation
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Analysis of nanoparticle delivery to tumours
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Metadata
- Authors
- Ruoslahti, E., Bhatia, S. N., & Sailor, M. J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2010-03-15
- Volume
- 188
- Issue
- 6
- Pages
- 759-768
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2147219712
- Cited by
- 829
- References
- 5
- FWCI
- 29.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ruoslahti, E., Bhatia, S. N., & Sailor, M. J. (2010). Targeting of drugs and nanoparticles to tumors. Journal of Cell Biology. https://doi.org/10.1083/jcb.200910104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
