Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages
Open accessAbstract
Although filamentous morphology in bacteria has been associated with resistance to phagocytosis, our understanding of the cellular mechanisms behind this process is limited. To investigate this, we followed the phagocytosis of both viable and dead Legionella pneumophila filaments. The engulfment of these targets occurred gradually and along the longitudinal axis of the filament, therefore defining a long-lasting phagocytic cup stage that determined the outcome of phagocytosis. We found that these phagocytic cups fused with endosomes and lysosomes, events linked to the maturation of phagosomes according to the canonical pathway, and not with the remodeling of phagocytic cups. Nevertheless, despite acquiring phagolysosomal features these phagocytic cups failed to develop hydrolytic capacity before their sealing. This phenomenon hampered the microbicidal activity of the macrophage and enhanced the capacity of viable filamentous L. pneumophila to escape phagosomal killing in a length-dependent manner. Our results demonstrate that key aspects in phagocytic cup remodeling and phagosomal maturation could be influenced by target morphology.
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Internalization of elongated pathogens is facilitated by actin clearance at the pseudopod base, which allows membrane invagination into the cytoplasm.
“Internalization of elongated pathogens has been reported to be facilitated by actin clearance at the pseudopod base, which allows membrane invagination into the cytoplasm [30].”
From Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis (2026) · cites this paper as [30]
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- Authors
- Prashar, A., Bhatia, S., Gigliozzi, D., Martin, T., Duncan, C., Guyard, C., & Terebiznik, M. R.
- Affiliations
- University of Toronto (CA)
- Ontario Agency for Health Protection and Promotion, Toronto, Ontario M5G 1V2, Canada 4
- Corresponding author
- Terebiznik, Mauricio R.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2013-12-23
- Volume
- 203
- Issue
- 6
- Pages
- 1081-1097
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC3871431
- OpenAlex
- W2105621253
- Cited by
- 76
- References
- 73
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 6 · 2014: 6 · 2013: 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (102514_1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Legionella and Acanthamoeba research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Legionella pneumophila, bacterial filaments, phagosome maturation, phagocytosis, macrophages, phagocytic cup, phagolysosomes, intracellular bacterial survival
- MeSH terms
- Animals, Cell Line, Macrophages, Mice, Inbred BALB C, Actin Cytoskeleton, Phagocytosis, Phagosomes, Surface Properties, Legionella pneumophila, Mice
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